Protein Alignment Herc4 and nedd4l

DIOPT Version :10

• Sequence 1: NP_001261249.1
• Gene: Herc4 / 38151
• FlyBaseID: FBgn0035207
• Length: 1062
• Species: Drosophila melanogaster
• Sequence 2: XP_021324693.1
• Gene: nedd4l / 559634
• ZFINID: ZDB-GENE-051118-2
• Length: 1274
• Species: Danio rerio
• Alignment Length: 585
• Identity: 165/585 - (28%)
• Similarity: 265/585 - (45%)
• Gaps: 94/585 - (16%)

  Fly   512 PADVESMRLYLLLPLYHEFVNSKHYKSLQVPFANAIFKLAENPRKVLNKWLAQTPAEYFEHLVQN 576
            |..:.|..:.|..||  |..|:       ||...|:.....||:       :..|:.|
Zfish   743 PRSLSSPTVTLSSPL--EGANN-------VPIRRAVKDTFSNPQ-------SPQPSPY------- 784

  Fly   577 FLHVVIHIISFKMGLAAASPSAERR--QQLLPYNTELEIILKLMKTLCQINNE----RHDRLNYQ 635
                             :||..:.:  |..||...|:.|...........|:.    ...||.|.
Zfish   785 -----------------SSPKTQHKANQSFLPPGWEMRIAPNGRPFFIDHNSRTTTWEDPRLKYP 832

  Fly   636 IFYWP----DLSDYADVQQEYVKWIMADTARDFNICNYSFIFDQSAKTALLQADQALQMHSAMAN 696
            :....    |..|...:...:.:.:.||        ..:|..|.:.|....: |..||..:....
Zfish   833 VHMRTKASLDPGDLGPLPPGWEERVHAD--------GRTFYIDHNNKKTQWE-DPRLQSPAITGP 888

  Fly   697 AATMAFSF---FNY-------GMPISQFIVLNVTRENLVQDSLRELQHYSQSD-LKKPLKIKFHG 750
            |...:..|   ::|       ...|.....:.:.|.|:.::|.|.:....:.| ||..|.|:|..
Zfish   889 AVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSLKRPDSLKARLWIEFES 953

  Fly   751 EEAEDAGGVRKEFFMLLLKDLLDPKYGMFKEYEQS-----RLLWFADLTFETENMYF-LIGVLCG 809
            |:..|.|||.:|:|.||.|::.:|.||:| ||..:     ::...:.|..|....|| .||.:.|
Zfish   954 EKGLDYGGVAREWFFLLSKEMFNPYYGLF-EYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAG 1017

  Fly   810 LAIYNFTIINLPFPLALFKKLLGKPVDLSDLRQLSPPEANSMQSLLDYQGDDFKEVFDLTFEISR 874
            :|:|:..:::..|....:|.:|||.:.|:|:..:.....||::.:|:   :|..|: ||.|.|..
Zfish  1018 MAVYHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILE---NDPTEL-DLRFCIDE 1078

  Fly   875 DVFGEAETKCLKPNGNEIAVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQ 939
            |.||:.....|||:|:::.||.:|::|::||.:.:.|...|:...|||.:||.::....:|.||.
Zfish  1079 DNFGQTYQVDLKPSGSDMVVTNDNKKEYIDLVIQWRFVNRVQKQMNAFLEGFTELIPIDLIKIFD 1143

  Fly   940 PEELMAVVVGNEDYDWQALQDNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLL-FLTGSDRI 1003
            ..||..::.|..|.|....:.:..|:.||......|:|||:.:. :.:|||:..|| |:||:.|:
Zfish  1144 ENELELLMCGLGDVDVNDWRQHTVYKNGYCPNHPVIQWFWKAVL-LMDAEKRIRLLQFVTGTSRV 1207

  Fly  1004 PIQGMKAL-------KLTIQP--TPDERFLPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGF 1059
            |:.|...|       ..||:.  |||:  ||.||||||.||||.|:|.|.|:.|||.|::..|||
Zfish  1208 PMNGFAELYGSNGPQLFTIEQWGTPDK--LPRAHTCFNRLDLPMYETFEDLREKLLMAVENAQGF 1270

  Fly  1060  1059
            Zfish  1271  1270

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	ATS1	7..352	CDD:444065
		RCC1	327..390	CDD:395335
		HECTc	715..1060	CDD:238033	126/362 (35%)
nedd4l	XP_021324693.1	C2	<374..430	CDD:472691
		WW	473..499	CDD:459800
		WW	669..698	CDD:459800
		WW	798..829	CDD:197736	5/30 (17%)
		WW	848..880	CDD:197736	6/40 (15%)
		HECTc	941..1270	CDD:214523	120/336 (36%)