DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Herc4 and herc2

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	XP_021332870.1	Gene:	herc2 / 558479	ZFINID:	ZDB-GENE-070718-6	Length:	4831	Species:	Danio rerio

Alignment Length:	1113	Identity:	261/1113 - (23%)
Similarity:	401/1113 - (36%)	Gaps:	351/1113 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LYCWGSTSHGQLGLGGIEDEQILTPSQIPWTPDTA------VQQVACGHRHTLF-LTATGKVYAC 64
            :|.||....||  |||||..::..|     ||..|      ||.:  |...||| :||.||:||.
Zfish  3951 IYGWGHNHRGQ--LGGIEGAKVKVP-----TPTEALATLRPVQLI--GGEQTLFAVTADGKLYAT 4006

  Fly    65 GSNDYSQLG------HDLPTKRPRMSPFLLIPELQDYVI--IQICCGSRHSLALSDWGQVLSWGD 121
            |.....:||      ...||         |:..:|...|  :.:..|.:|.||||..|::.|||:
Zfish  4007 GYGAGGRLGIGGTESVSTPT---------LLESIQHVFIRKVAVNSGGKHCLALSSEGELYSWGE 4062

  Fly   122 NDCGQLGHATDKEIVQLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGSNIYGQLGVNSPN 186
            .:.|:|||. ::.....|:|:..|....||.||.|..||..:|:.||||:||...||:||.....
Zfish  4063 AEDGKLGHG-NRSPCDRPRVIESLRGVEVVDIAAGGAHSACITASGELYTWGKGRYGRLGHGDSE 4126

  Fly   187 DLTHCNYPLRLTTLLGIPLAAIACGGN--HSFLISKSGAVFGWGRNNCGQLGLNDETNRSYPTQL 249
            |...   |..:..|.|..:..:|||..  .:..::....|:.||..:.|:||.........|.::
Zfish  4127 DQLK---PKLVEALQGHRVIDVACGSGDAQTLCLTDDDMVWSWGDGDYGKLGRGGSDGCKVPMKI 4188

  Fly   250 KTLRTLGVRFVACGDEFSVFLTNEGGVFTCGAGAYGQLGHGFSSNEMLPRMVMELMGSTITQVAC 314
            .:|..|||..|.||.:|||.||..|.|:|.|.|.|.:||||...:...||.|..|.|..:..:|.
Zfish  4189 DSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIAT 4253

  Fly   315 GNRHTLALVPSRGRVYAFGLGSSGQLGTRSTKSLMLPQVVIGPWVSPSGSALLQSNDSQVSLVIR 379
            |:.|.:..... |.||.:|....||||..:|.::..|::|          |.||...      |.
Zfish  4254 GSLHCVCCTED-GEVYTWGDNDEGQLGDGTTNAIQRPRLV----------AALQGKK------IN 4301

  Fly   380 QIFSGGDQSIVTTT---LFVDKVPPEDFRNYNPKSQILTLTAEVTKQCAQCKQGLQSDMDLLSSI 441
            ::..|...::..:|   ....|:|.:....||...:|..:             ||::.:.||..|
Zfish  4302 RVACGSAHTLAWSTSKPTNAGKLPAQVPMEYNHLQEIAII-------------GLRNRLLLLHHI 4353

  Fly   442 ELIFRSQACWNGSFLLDHDRHFGCSVRNHGLDLKAAQLAFDNLRAV-----ENESIRQVIWDNIT 501
            ..:|  ..|..   :.|.:...|  ...||:     .:.||.||.:     :..:.|:|:...:.
Zfish  4354 SELF--CPCIP---MFDLEGRLG--ETGHGV-----SVGFDTLRGILISQGKEAAFRKVVQATMV 4406

  Fly   502 KELVGSLVCSPADVESMRLYLLLPLYHEFVNSKHYKSLQVPFANAIFKLAENPRKVLNKWLAQTP 566
            ::.....|     ||..|:.:           |..:|
Zfish  4407 RDRQHGPV-----VELNRIQV-----------KRSRS---------------------------- 4427

  Fly   567 AEYFEHLVQNFLHVVIHIISFKMGLAAASPSAERRQQLLPYNTELEIILKLMKTLCQINNERHDR 631
                                 |.|||.
Zfish  4428 ---------------------KGGLAG-------------------------------------- 4433

  Fly   632 LNYQIFYWPDLSDYADVQQEYVKWIMADTARDFNICNYSFIFDQ-SAKTALLQADQALQMHSAMA 695
                    ||                          ....:|.| .||.:....|..|..|
Zfish  4434 --------PD--------------------------GTKSVFGQMCAKMSSFSPDSLLLPH---- 4460

  Fly   696 NAATMAFSFFNYGMPISQFIVLNVTRENLVQDSLRELQHYSQSDLKKPLKIKFHGEEAEDAGGVR 760
                                                          :..|:||.||..:|.||..
Zfish  4461 ----------------------------------------------RVWKVKFVGESVDDCGGGY 4479

  Fly   761 KEFFMLLLKDLLDPKYGMFKEYEQSRLLWFADLTFETEN-------------------------M 800
            .|....:.::|            |:.|   ..|...|.|                         |
Zfish  4480 SESIAEMCEEL------------QNGL---TPLLIVTPNGRDESGANRDCFLLNPAAKSPLHISM 4529

  Fly   801 YFLIGVLCGLAIYNFTIINLPFPLALFKKLLGKPVDLSDLRQLSPPEANSMQSLLDYQ--GDDFK 863
            :..:|||.|:||...:.::|.....::|:|.|..:.::||.::.......:..:.|.:  .::|
Zfish  4530 FRFLGVLLGIAIRTGSPLSLYLAEPVWKQLAGMNLTIADLSEVDKDFIPGLMYIRDNEASAEEF- 4593

  Fly   864 EVFDLTFEISRDVFGEAETKCLKPNGNEIA-------VTLENRQEFVDLYVDFVFNKSVELHYNA 921
            |...|.|.:        .:.|    |.|:.       ::||||.|:|.|.:::..::..| ..:|
Zfish  4594 EAMPLPFTV--------PSAC----GQEVQLSSKHSHISLENRSEYVRLAINYRLHEFDE-QVSA 4645

  Fly   922 FHKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQALQDNCEYREGYTSVDDTIKWFWEVIHDMS 986
            ..:|..:|....::.:|...||..:|.|:.|.....|:....|: |.......|:|||||:...|
Zfish  4646 VREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYK-GVEPTAPLIQWFWEVMESFS 4709

  Fly   987 EAEKKSFLLFLTGSDRIP--IQGMKALKLTIQP----TPDERFLPVAHTCFNLLDLPRYKTK--- 1042
            ..|:..||.|:.|..|:|  |...:.....:|.    .|.:.|||.::|||.||.||||..|
Zfish  4710 NTERSLFLRFVWGRTRLPRTIADFRGRDFVVQVLDKYNPPDHFLPESYTCFFLLKLPRYSCKLVL 4774

  Fly  1043 -ERLKYKL 1049
             |:|||.:
Zfish  4775 EEKLKYAI 4782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826	20/54 (37%)
		RCC1	59..110	CDD:278826	15/58 (26%)
		RCC1	114..163	CDD:278826	18/48 (38%)
		RCC1	167..218	CDD:278826	17/52 (33%)
		RCC1	221..270	CDD:278826	17/48 (35%)
		RCC1	273..322	CDD:278826	18/48 (38%)
		RCC1_2	309..339	CDD:290274	7/29 (24%)
		RCC1	327..390	CDD:278826	16/62 (26%)
		HECTc	715..1060	CDD:238033	90/379 (24%)
		HECTc	739..1059	CDD:214523	90/355 (25%)
herc2	XP_021332870.1	RCC1	<483..772	CDD:332518
		Cyt-b5	1204..1276	CDD:306642
		MIB_HERC2	1862..1920	CDD:310955
		UBA_HERC2	2453..2499	CDD:270585
		Cul7	2548..2625	CDD:314424
		ZZ_HERC2	2700..2744	CDD:239084
		APC10-HERC2	2759..2902	CDD:176485
		RCC1	2946..3316	CDD:332518
		RCC1	4020..4325	CDD:332518	102/334 (31%)
		HECTc	4418..4789	CDD:238033	106/577 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920