DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Herc4 and LOC556872

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	XP_021334149.1	Gene:	LOC556872 / 556872	-ID:	-	Length:	1472	Species:	Danio rerio

Alignment Length:	305	Identity:	69/305 - (22%)
Similarity:	107/305 - (35%)	Gaps:	84/305 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   272 NEGGVFTCGAGAYGQLGHGFSSNEMLPR--MVMELMGSTITQVACGNRHTLALVP------SRGR 328
            ::|..||....|....|   |.|..:|.  .:..::||.:..:|.|..    |||      .||.
Zfish   663 SDGPYFTFNGTASASSG---SPNSSIPSPGALSAVIGSGVGGMAAGGE----LVPVALAKCERGS 720

  Fly   329 VYAFGLGSSGQLGTRSTKSLMLPQVVIGPWVS------PSGSALLQSND--------SQVSLVIR 379
            ...|.:.:.|. |.|.|       :|...|..      .||.|:::.|.        :||..:::
Zfish   721 NMGFSVTAGGH-GGRQT-------LVKKVWDHRQCNGLQSGDAVVKINGADVQSLSFAQVQRILQ 777

  Fly   380 QIFSGGDQSIVTTTLFVDKVPPEDFRNY-NPKSQILTLTAEVTKQCAQCKQGLQSDMDLLSSIEL 443
            :....|:     ..|.|.:.|    .|| |..|.:..||....:..:      .|::....|:.|
Zfish   778 EHTKKGE-----VILLVYRGP----SNYSNSPSSVRRLTPPPPRSAS------DSEVPFTDSMPL 827

  Fly   444 -----------IFRSQACWNGSFL------LDHDRHFGCSVRNHGLDLKAAQLAFDN-----LRA 486
                       :.||....:.|||      |..:.....|..:.|..|.......:.     ||.
Zfish   828 SRNSLTPPSPALVRSSLVQSTSFLDSVPVTLTLEPRDWMSSEDGGTVLSPRVKTEEKEQPPALRG 892

  Fly   487 VENESIRQVIWDNITKELVGSLVCSPADVESMRLYLLLPLYHEFV 531
            .|.|..|:      ..|..|.::.| .|||:::...|||  |.||
Zfish   893 YEVELKRK------PGEGFGFVIAS-QDVENVKAVSLLP--HRFV 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826
		RCC1	59..110	CDD:278826
		RCC1	114..163	CDD:278826
		RCC1	167..218	CDD:278826
		RCC1	221..270	CDD:278826
		RCC1	273..322	CDD:278826	12/50 (24%)
		RCC1_2	309..339	CDD:290274	8/35 (23%)
		RCC1	327..390	CDD:278826	15/76 (20%)
		HECTc	715..1060	CDD:238033
		HECTc	739..1059	CDD:214523
LOC556872	XP_021334149.1	PDZ_signaling	24..88	CDD:238492
		NK	111..>190	CDD:327404
		PDZ_signaling	365..440	CDD:238492
		PDZ	722..791	CDD:238080	16/81 (20%)
		PDZ_signaling	893..980	CDD:238492	15/45 (33%)
		PDZ_signaling	1017..1093	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900