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Protein Alignment Herc4 and ube3b

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_001108154.1	Gene:	ube3b / 556864	ZFINID:	ZDB-GENE-060526-231	Length:	1069	Species:	Danio rerio

Alignment Length:	931	Identity:	201/931 - (21%)
Similarity:	330/931 - (35%)	Gaps:	235/931 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   321 ALVPSRGRVYAFGLGSSGQLGTRSTKSLMLPQVVIGPWVSPSGSALLQSNDSQVSLVIRQIFSGG 385
            ||.|:..|:....:|...|.|..|...::|...:.....|.|...|.......:..||...||
Zfish   183 ALKPALNRICENIMGHLNQKGFYSVLQILLTNGLARSRPSLSKGTLTAIFTLSLRPVIAAHFS-- 245

  Fly   386 DQSIVTTTLFVDKVPPEDFRNYNPKSQILTLTAEVTKQCAQCKQGLQSDMDLLSSIEL-IFRSQA 449
            |..:.:..|.|..||..       .|.:.|||.:       |...:|:. ||.....| :.|.:.
Zfish   246 DNLLRSFLLHVMSVPAF-------ISHLNTLTPD-------CMITIQTH-DLFRKFVLFLSREEQ 295

  Fly   450 CWNGSFLLDHDRHFGCSVRNHGLDLKAAQLAFDNLRAVENESIRQVIWDNITKELVGSLVCSPAD 514
            |.:....|: ..|..|.:.|      ..||.:.|::.:|.|:      .:..|:|...|......
Zfish   296 CLDICVCLE-GSHTLCLLGN------LIQLGYFNVKVLEQEA------GHFVKDLTDMLSYCQRY 347

  Fly   515 VESMRLYLL--LPLYHEFVNSKHY----------KSLQ----VP-----FANAIFKLAEN----- 553
            |...:..|.  .|:...|..:..|          |.||    ||     |.:.:.|..|.
Zfish   348 VSQKKSNLTHWHPVLGWFSQTVDYGLNESMPLVTKQLQCLWGVPVICTLFCDVLSKKLETQDPTP 412

  Fly   554 -------------PRKVLNKWLAQTPAEYFEHLVQNFL--------------HVVIHIISFKMGL 591
                         |.|.|.|...|..|.     |:|.|              .|....:.::..|
Zfish   413 PPAPQPSSLQNNLPVKNLFKRAFQKSAS-----VRNILKPVGGKRVDSAEVQKVCSICVLYQTAL 472

  Fly   592 AAASPSAERRQQLLPYNTEL-EIILKLMKTLCQ-------------INN--ERHDRLNYQIFYWP 640
            ...:   :.|.|:|...|.| |::.||...:|:             :||  |...:|...:..:.
Zfish   473 TTLT---QIRLQILTGLTYLDELLPKLWAFICELGPQGGLRLFLECLNNDTEESKQLLAMLMLFC 534

  Fly   641 DLS-------DYADVQQEYVKWIMAD--TARDF-NICNYSFIFD---QSAK-------------- 678
            |.|       |..:|.:|.:.:.|.:  |...| |...|..::|   ::||
Zfish   535 DCSRHLITILDDIEVYEEQISFKMEELVTISSFLNTFVYKMVWDGILENAKGEKLDLFHSVHGWL 599

  Fly   679 TALLQAD----------------------QALQMHSAMANAATMAFSFFNYGMPISQFIVL---- 717
            ..|.:.|                      |.|:...   ..|.:...:..:.:|....::|
Zfish   600 MVLYERDCRRRFTPEDHWLRKDLKPSLLFQELEKGK---KRAQLLLQYIPHVIPHKNRVLLFRNI 661

  Fly   718 -----------------------NVTRENLVQDSLRELQHYSQSDLKKPLKIKFHG-----EEAE 754
                                   .:.|..:::|...:|:....:.:|..:::||..     |...
Zfish   662 VTKEKETLGLVETSSASPHVTHITIRRSRMLEDGYDQLRRLPVNSIKGVIRVKFVNDLGVDEAGI 726

  Fly   755 DAGGVRKEFFMLLLKDLLDPKYGMFKEYEQSRLLWFADLTFETEN---MYFLIGVLCGLAIYNFT 816
            |..||.|||...::|.:.:|...:||....:..|:.:..:...||   ::..:|.:.|.|:|...
Zfish   727 DQDGVFKEFLEEIIKKVFNPALNLFKTTSGNERLYPSPTSSIHENHLQLFEFVGKMLGKAMYEGI 791

  Fly   817 IINLPFPLALFKKLLGKP-----VDLSDLRQLSPPEANSMQSLLDYQGDDFKEVFDLTFEISRD- 875
            ::::||......::||..     ..:.:|..|......::.|:..|.||    |.||...:|.|
Zfish   792 VVDVPFASFFLSQVLGHHHSTFYSSIDELPSLDSEFYKNLTSIKRYDGD----VSDLGLTLSYDE 852

  Fly   876 -VFGEAETKCLKPNGNEIAVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQ 939
             |.|:.....|.|.|..:.||.||:..::.|...|..:..::....||.:||..:.:...:|:|.
Zfish   853 EVMGQLVCHELIPGGKTMPVTNENKISYIHLMAHFRMHTQIKEQTAAFIRGFRSIINPEWLHMFS 917

  Fly   940 PEELMAVVVG-NEDYDWQALQDNCEYREGYTSVDDTIKWFWEVI-HDMSEAEKKSFLLFLTGSDR 1002
            ..|:..::.| |.:.|...|:.:..|..|:.|....|.|.|::: .|.:..|:..||.|:|...|
Zfish   918 TPEVQRLISGDNAEIDLDDLKKHTVYYGGFHSSHRVILWLWDILSSDFTPDERAMFLKFVTSCSR 982

  Fly  1003 IPIQGMKALK---------------------------LTIQPTPDERFLPVAHTCFNLLDLPRYK 1040
            .|:.|...||                           .||:.......||.:.||||||.||.|.
Zfish   983 PPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKKEPGGRLPTSSTCFNLLKLPNYS 1047

  Fly  1041 TKERLKYKLLQAIQQTQGFSL 1061
            .|..|:.||..||....||.|
Zfish  1048 KKSILRDKLRYAISMNTGFEL 1068

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.