DRSC/TRiP Functional Genomics Resources

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Protein Alignment Herc4 and PLEKHA5

DIOPT Version :9

Sequence 1:NP_001261249.1 Gene:Herc4 / 38151 FlyBaseID:FBgn0035207 Length:1062 Species:Drosophila melanogaster
Sequence 2:NP_001243399.1 Gene:PLEKHA5 / 54477 HGNCID:30036 Length:1282 Species:Homo sapiens


Alignment Length:712 Identity:133/712 - (18%)
Similarity:217/712 - (30%) Gaps:282/712 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   291 FSSNEMLPRMVMELMGSTITQVACGNRHTLALVPSRGRVYAFGLGSSGQLGTRSTKSLMLPQVVI 355
            ::....|||........|:..::....|::...||.|.:.|: .|.|.|...||..|        
Human   518 YNKQSTLPRHSTLSSPKTMVNISDQTMHSIPTSPSHGSIAAY-QGYSPQRTYRSEVS-------- 573

  Fly   356 GPWVSPSGSALLQSNDSQVSLVIR-----QIFSGGDQSIVTTTLFVDKVPPEDFRNYNPKSQILT 415
                ||     :|..|..:....|     .::. .|:..|...|.:..|.|:..:...|: ::..
Human   574 ----SP-----IQRGDVTIDRRHRAHHPKHVYV-PDRRSVPAGLTLQSVSPQSLQGKTPE-ELTL 627

  Fly   416 LTAEVTKQCAQCKQGLQSDMDLLSSIELIFRSQACWNGSFLLDHDRHFGCSVRNHGLDLKAAQLA 480
            |..::.:|.|:           ||||                          |.|.|    |||.
Human   628 LLIKLRRQQAE-----------LSSI--------------------------REHTL----AQLM 651

  Fly   481 FDNLRA--VENESIRQVIWDNITKELVGSLVCSPADVESMRLYLLLPLYHEFVNSKHYKSLQVPF 543
            ...|.|  .:||.:...:..|                   .:||           .|......|.
Human   652 QLKLEAHSPKNEILSHHLQRN-------------------TIYL-----------DHQMKENEPI 686

  Fly   544 ANAIFKLAENPRKVLNKWLAQTPAEYFEHLVQNFLHVVIHIISFKMGLAAASPSAERRQQLLPYN 608
            ...:..:.||.        |..|..|.:.|.|          ..|:.|...|.. |.|..|..|.
Human   687 ITMVHTMIENS--------ALRPQLYQQFLRQ----------KSKISLYCLSQD-EGRGTLYKYR 732

  Fly   609 -TELEIILKLMKTLCQINNERHDRLNYQIFYWPDLSDYADVQQEYVKWIMADTARDFNICNYSFI 672
             .|::|..||.: ||                          :|:.|...:.:..:..:...|:. 
Human   733 PEEVDIDAKLSR-LC--------------------------EQDKVVHALEEKLQQLHKEKYTL- 769

  Fly   673 FDQSAKTALLQADQALQMHSAMANAATMAFSFFNYGMPISQFIVLNVTRENLVQDSL----RELQ 733
                 :.|||.|.|.::||:  .|.|.:            |.:||.  |::| |:.|    |||.
Human   770 -----EQALLSASQEIEMHA--DNPAAI------------QTVVLQ--RDDL-QNGLLSTCRELS 812

  Fly   734 HYSQSDLKKPL----KIKFH---------------GEEAEDAGGVRKEFFMLLLKDLLDPKYGMF 779
            . :.::|::..    |:::.               ||...::.|:::......|..:.|...|:.
Human   813 R-ATAELERAWREYDKLEYDVTVTRNQMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLS 876

  Fly   780 KEYEQSRLLWFADLTFETENMYFLIGVLCGLAIYNFTIINLPFPLALFKK----------LLGKP 834
            |..:|..         .||     ||:          |.:.||....:|.          .|.:.
Human   877 KHKQQRG---------TTE-----IGM----------IGSKPFSTVKYKNEEEEVVPPRPPLPRS 917

  Fly   835 VDLSDLRQLSPPEANSMQSLLDYQ-------------------------GDDFK----------- 863
            .|.::...:.||..:...|||.|.                         |.|::           
Human   918 YDFTEQPPIIPPLPSDSSSLLCYSRGPVHLPEEKKMYQVQGYPRNGSHCGPDYRLYKSEPELTTV 982

  Fly   864 -EVFDLTFEISRDVFGEAETKCLK-----------------PNGNEIA--VTLENRQEFVDL 905
             ||.:...|...:...|.||..:|                 |..:.||  |||...::.:||
Human   983 AEVDESNGEEKSEPVSEIETSVVKGSHFPVGVVPPRAKSPTPESSTIASYVTLRKTKKMMDL 1044

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Herc4NP_001261249.1 RCC1 6..55 CDD:278826
RCC1 59..110 CDD:278826
RCC1 114..163 CDD:278826
RCC1 167..218 CDD:278826
RCC1 221..270 CDD:278826
RCC1 273..322 CDD:278826 5/30 (17%)
RCC1_2 309..339 CDD:290274 7/29 (24%)
RCC1 327..390 CDD:278826 14/67 (21%)
HECTc 715..1060 CDD:238033 52/280 (19%)
HECTc 739..1059 CDD:214523 43/252 (17%)
PLEKHA5NP_001243399.1 WW 12..41 CDD:278809
WW 58..87 CDD:278809
PH_PEPP1_2_3 164..267 CDD:270068
PH 170..266 CDD:278594
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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