DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Herc4 and HERC5

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	XP_011530324.2	Gene:	HERC5 / 51191	HGNCID:	24368	Length:	1100	Species:	Homo sapiens

Alignment Length:	1088	Identity:	349/1088 - (32%)
Similarity:	520/1088 - (47%)	Gaps:	226/1088 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KELYCWGSTSHGQL-----GLGGIEDEQIL-------TPSQIPWTPDTAVQQVACGHRHTLFLTA 57
            ::|.|    |.|:|     |..|::..|:|       ||..|....:..:..|..|..|.|.|::
Human   205 RQLCC----SPGRLAVLERGGAGVQVHQLLAGSGGARTPKCIKLGKNMKIHSVDQGAEHMLILSS 265

  Fly    58 TGKVYACGSNDYSQLGHDLPTKRPRMSPFLLIPELQDYVIIQICCGSRHSLALSDWGQVLSWGDN 122
            .||                        ||    |..:|
Human   266 DGK------------------------PF----EYDNY--------------------------- 275

  Fly   123 DCGQLGHATDKEIVQLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGSNIYGQLGVNS--P 185
               .:.|...:.|:|         .|.::||.||:.|||||:..|||::||.|::|||||..  |
Human   276 ---SMKHLRFESILQ---------EKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFP 328

  Fly   186 NDLTHCNYPLRLTTLLGIPLAAIACGGNHSFLISKSGAVFGWGRNNCGQLGLNDETNRSYPTQLK 250
            :..|    |..:..|.|:|||.|:.|..||..:|.||.::.||:|.||||||....::..|:.::
Human   329 STTT----PQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIE 389

  Fly   251 TLRTLGVRFVACGDEFSVFLTNEGGVFTCGAGAYGQLGHGFSSNEMLPRMVMELMGSTITQVACG 315
            .|....|.|||||...|..||.:|.:||.|||.:|||||..:.||:.|.:|.||:|..:||:|||
Human   390 GLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACG 454

  Fly   316 NRHTLALVPSRGRVYAFGLGSSGQLGTRSTKSLMLPQVVIGPWVSPSGSALLQSNDSQVSLVIRQ 380
            ..||||.|...|:|::||.|..||||...|:..::|..|   .||.|....|:|:.|:..|:
Human   455 RWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPV---KVSSSEELKLESHTSEKELI--- 513

  Fly   381 IFSGGDQSIVTTTLFVDKVPPEDFRNY-NPKSQILTLT--------AEV-TKQCAQCKQGLQSDM 435
            :.:||:|||:   |::.|.     .:| |.|..|.||.        |:| ||:....|:.:|.
Human   514 MIAGGNQSIL---LWIKKE-----NSYVNLKRTIPTLNEGTVKRWIADVETKRWQSTKREIQE-- 568

  Fly   436 DLLSSIELIFRSQACWNGSFLLDHDRHFGCSVRNHGLDLKAAQLAFDNLRAVE--NESIRQVIWD 498
                    ||.|.||..||||   .:.....:....|||..|:..|..|...:  ...|...:.|
Human   569 --------IFSSPACLTGSFL---RKRRTTEMMPVYLDLNKARNIFKELTQKDWITNMITTCLKD 622

  Fly   499 NITKELVGSLVCSPADVESMRLYLLLPLYHEFVNSKHYKSLQVPFANAIFKLAENPRKVLNKWLA 563
            |:.|.|.   ..||.. |::.::.|||.......|.:::||.||||..:.|:::....||.::.|
Human   623 NLLKRLP---FHSPPQ-EALEIFFLLPECPMMHISNNWESLVVPFAKVVCKMSDQSSLVLEEYWA 683

  Fly   564 QTPAEYFEHLVQNFLHVVIHIISFKMGLAAASPSAERRQQLLPYNTELEIILKLMKTLCQINNER 628
            ......|..|||.|...||..:.:      ...|||.       |..::.:|:::|.|.:  :::
Human   684 TLQESTFSKLVQMFKTAVICQLDY------WDESAEE-------NGNVQALLEMLKKLHR--SKK 733

  Fly   629 HDRLNYQIFYWPDLSDYADVQQEYVKWIMADTARDFNICNYSFIFDQSAKTALLQADQALQMHSA 693
            |                    :.|::....:..|:
Human   734 H--------------------KAYLRSAAIEEERE------------------------------ 748

  Fly   694 MANAATMAFSFFNYGMPISQFIV-----LNVTRENLVQDSLRELQHYSQSDLKKPLKIKFHGEEA 753
                              |:|.:     |.|.|.:|::|.|.:|..:...||:|.|.:.|.||..
Human   749 ------------------SEFALRPTFDLTVRRNHLIEDVLNQLSQFENEDLRKELWVSFSGEIG 795

  Fly   754 EDAGGVRKEFFMLLLKDLLDPKYGMFKEYEQSRLLWFADLTFETENMYFLIGVLCGLAIYNFTII 818
            .|.|||:||||..|..:::.|:||||...|.:..:||.......:..||..||||||:::|..:.
Human   796 YDLGGVKKEFFYCLFAEMIQPEYGMFMYPEGASCMWFPVKPKFEKKRYFFFGVLCGLSLFNCNVA 860

  Fly   819 NLPFPLALFKKLLGKPVDLSDLRQLSPPEANSMQSLLDYQGDDFKEVFDLTFEISRDVFGEAETK 883
            |||||||||||||.:...|.||::|||....::|:|||.:||:|:|||.:.|.:..|   ..:|.
Human   861 NLPFPLALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHWD---RNDTN 922

  Fly   884 CLKPNGNEIAVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVV 948
             |.|||:.|.|...|::::|..|::::||.||:..|..|.:||.|:|...:|.:|.||||..|:|
Human   923 -LIPNGSSITVNQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIV 986

  Fly   949 GNEDYDWQALQDNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKALKL 1013
            ||.||||:..:.|..|..||.|...||..||:..|.::..|||.||:||||:||:.::.:..:|:
Human   987 GNTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDLNNMKI 1051

  Fly  1014 TI--QPTPDERFLPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGF 1059
            |.  ..:.:||....|.|||::|.||:|.|.|.::..|.:||...:||
Human  1052 TFCCPESWNERDPIRALTCFSVLFLPKYSTMETVEEALQEAINNNRGF 1099

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826	16/60 (27%)
		RCC1	59..110	CDD:278826	6/50 (12%)
		RCC1	114..163	CDD:278826	11/48 (23%)
		RCC1	167..218	CDD:278826	23/52 (44%)
		RCC1	221..270	CDD:278826	20/48 (42%)
		RCC1	273..322	CDD:278826	26/48 (54%)
		RCC1_2	309..339	CDD:290274	15/29 (52%)
		RCC1	327..390	CDD:278826	23/62 (37%)
		HECTc	715..1060	CDD:238033	145/352 (41%)
		HECTc	739..1059	CDD:214523	136/321 (42%)
HERC5	XP_011530324.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57432
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	1	1.000	-	-		FOG0001110
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45622
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X678
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.890