DRSC/TRiP Functional Genomics Resources

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Protein Alignment Herc4 and Wwc2

DIOPT Version :9

Sequence 1:NP_001261249.1 Gene:Herc4 / 38151 FlyBaseID:FBgn0035207 Length:1062 Species:Drosophila melanogaster
Sequence 2:NP_001102581.1 Gene:Wwc2 / 498630 RGDID:1559427 Length:1194 Species:Rattus norvegicus


Alignment Length:547 Identity:109/547 - (19%)
Similarity:173/547 - (31%) Gaps:191/547 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   365 ALLQSNDSQVSLVIRQIFSGGDQSIVTTTLFVDKVPPEDFRNYNP---KSQILTLTAEVTK---Q 423
            |..:.:.|..||     |||...|                ..|:|   |::|.|....|.|   :
  Rat   138 AYKEKSSSHTSL-----FSGSSSS----------------TKYDPDILKAEISTTRLRVKKLKRE 181

  Fly   424 CAQCKQGLQSDMDLLSSIELIFRSQACWNGSFLLDHDRHFGCSVRNHGLDLKAAQLAFDNLRAV- 487
            .:|.||            ||:::.|. :.....:|.....|.|    |.:|..|:.....|::: 
  Rat   182 LSQMKQ------------ELLYKQQG-FETLQQIDEKMSGGQS----GYELSEAKAILTELKSIR 229

  Fly   488 ----ENESIRQVIWDNITK--------ELVGS----LVCSPADVESMRLYLLLPLYHEFVNSKHY 536
                ..|..:|.:..::.|        :.:||    |.|||                  |||  :
  Rat   230 KAISSGEKEKQDLMQSLAKLQERFHLDQNMGSSEPDLRCSP------------------VNS--H 274

  Fly   537 KSLQVPFANAIFKLAENPRKVLNKWLAQTPAEYFEHLVQNFLHVVIHIISFKMGLAAASPSAERR 601
            .||.              |:.|:.. :||.                  ||..:|:.:.|..||:.
  Rat   275 LSLS--------------RQTLDAG-SQTS------------------ISGDIGVRSRSNLAEKV 306

  Fly   602 QQLLPYNTELEIILKLMKTLCQINNERHDRLNYQIFYWPDLSDYADVQQEYVKWIMADTARDFNI 666
            :..|.|......:..|...|.:::.|.          ||..   .||::|.   :|....::..:
  Rat   307 RLSLQYEEAKRSMANLKIELSKLDGEA----------WPGA---LDVEKEK---LMLINEKEELL 355

  Fly   667 CNYSFIFDQSA---KTALLQAD-QALQMHSAMANAATMAFSFFNYGMP---ISQFIVLNVTRENL 724
            ....||..|..   :...|:|: |.|:.....|.           |:|   :::.:.|...|:.|
  Rat   356 KELQFITPQKRTQDELERLEAERQRLEEELVAAR-----------GLPSRALAERLKLEEKRKEL 409

  Fly   725 VQ--DSLRELQHYSQSDLKKPLKIKFH-------GEEAEDAGGV----RKEFFMLLLKDLLDPKY 776
            :|  :...:|..|..|.||........       |..|...|.:    |.....|...||.....
  Rat   410 LQKLEETTKLTTYLYSQLKSLSSSTLSMSSGSSLGSLASSRGSLNTSSRGSLNSLSSSDLYYSSQ 474

  Fly   777 G--MFKEYEQSRLLWFADLTFETENMYFLIGV--------------------LCGLAIYNFTIIN 819
            |  |..:|:     :..|...:.:..|...|.                    ||||.:  ....:
  Rat   475 GDQMDTDYQ-----YKLDFLLQEKGGYIPSGPITTIHENEVVKSPSQPGQSGLCGLGV--AATSH 532

  Fly   820 LPFPLALFKKLLGKPVDLSDLRQLSPP 846
            .| ||....|.:......|.|..||||
  Rat   533 TP-PLTEASKSVTSLSSRSSLSSLSPP 558

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Herc4NP_001261249.1 RCC1 6..55 CDD:278826
RCC1 59..110 CDD:278826
RCC1 114..163 CDD:278826
RCC1 167..218 CDD:278826
RCC1 221..270 CDD:278826
RCC1 273..322 CDD:278826
RCC1_2 309..339 CDD:290274
RCC1 327..390 CDD:278826 8/24 (33%)
HECTc 715..1060 CDD:238033 36/167 (22%)
HECTc 739..1059 CDD:214523 29/141 (21%)
Wwc2NP_001102581.1 WW 12..41 CDD:278809
WW 59..88 CDD:278809
DUF342 <283..385 CDD:302792 26/136 (19%)
YlqD 351..>420 CDD:287979 14/79 (18%)
C2_Kibra 699..822 CDD:176062
Phage_Nu1 <1095..>1153 CDD:294991
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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