DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Herc4 and arel1

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_001011393.1	Gene:	arel1 / 496863	XenbaseID:	XB-GENE-5852856	Length:	806	Species:	Xenopus tropicalis

Alignment Length:	906	Identity:	174/906 - (19%)
Similarity:	302/906 - (33%)	Gaps:	288/906 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   240 ETNRSYPTQLKTLR--TLGVRFVACGDEFSVFLTNEGGVFTCGAGAYG-QLGHG-----FSSNEM 296
            |.:...|..|:.|:  |..|..||       |...:.|.:.......| .:||.     ||...:
Frog   106 ELDLEVPITLEVLQDSTRNVMKVA-------FTVRKSGRYQINISIGGLNIGHSPYYKIFSPGAV 163

  Fly   297 LPRMVMELMGSTITQVACGNRHTLALVPSRGRVYAFGLGSSGQLGTRSTKSLMLPQVVIGPWVSP 361
            :|.....:...:...:.||.:|||.:||            ..|.|..::.||
Frog   164 VPSKTQIVSHFSTLVLKCGEQHTLQVVP------------RDQYGNHTSDSL------------- 203

  Fly   362 SGSALLQSNDSQVSLVIRQIFSGGDQSIVTTTLFVDKVPPEDFRNYNPKSQILTLT----AEVTK 422
                                                    :|..:|     ||||:    ..|..
Frog   204 ----------------------------------------KDLESY-----ILTLSELGVVGVAD 223

  Fly   423 QCAQCKQGLQSDMDLLSSIELIFRSQACWNGSFLLDHDRHFGCSVRNHGLDLKAAQLAFDNLRAV 487
            .|.|......|...:|..:.|:  ...|            |..::|..||.:....  |..:...
Frog   224 GCLQVSVCSGSQNRVLLHLALL--QTGC------------FQATLRFQGLPINNGN--FQIIVLT 272

  Fly   488 ENESIRQVIWDNITKELVGSLVCSPADVESMRLYLLLPLYHEFVNSKHYKSLQVPFANAIFKLAE 552
            :.|  :.::.:|:::..||                                  |.|...::..:.
Frog   273 DGE--KTIVDNNVSRSGVG----------------------------------VFFEGYLYPPSS 301

  Fly   553 NPRKVLNKWLAQTPAEYFEHLVQNFLHVVIHIISFKMGLAAASPSAERRQQLLPYNTELEIILKL 617
            :|         ..|.::                      .::|.|          |.|
Frog   302 SP---------NIPGQH----------------------RSSSTS----------NDE------- 318

  Fly   618 MKTLCQINNERH--DRLN--YQIFYW--PDLSDYADVQQEYVKWIMADTARDFNIC-NYSFIF-- 673
                 :.|.:.|  |||.  .:::::  |......:.....:.|.:.    .|.:| ...|::
Frog   319 -----ESNADGHTVDRLKKPKKVYFYITPKQLSVKEFYLRIIPWRLF----TFRVCPGTKFLYLP 374

  Fly   674 -DQSAKTALLQADQALQ--------------------MHSAMANAATMAFSFFNYGMPISQF--- 714
             |.......||.|..||                    :|..:..:.|.......:...:.|.
Frog   375 PDPLHGLLSLQVDDGLQPPIEISCKDRNIMAATFTRFLHLNIGGSETFQDKVTFFQKELRQIHCK 439

  Fly   715 -----IVLNVTRENLVQDSLRELQHYSQSDLKKPLKIKFHGEEAEDAGGVRKEFFMLLLKDLLDP 774
                 :.|.|.|.:|::.|||..:::|.||..|..::.|..|||.|.||.|:|:|.|:.|.|.|.
Frog   440 KTRCKVTLKVNRHSLLESSLRATRNFSASDWCKNFEVVFQDEEALDWGGPRREWFELICKTLFDT 504

  Fly   775 KYGMFKEYEQSRLLWFADLTFETEN----MYFLIGVLCGLAIYNFT-------IINLPFPLALFK 828
            ...:|..:..|.............|    :|...|.:.|..::..:       ::...|..:...
Frog   505 NNQLFIRFSDSNQGLVHPNPCRPPNIRVKLYEFAGRVVGKCLFESSLGGGCEQLVRARFTRSFLA 569

  Fly   829 KLLGKPVDLSDLR------QLSPPE--ANSMQSLLDYQGDDFKEVFDLTFEISRDVFGEA----E 881
            :::|       ||      :...|:  ...:|.:|.      .:|.|.....:.:.:|.|    :
Frog   570 QIIG-------LRMHYKYFETDDPDFFQTKVQYILT------NDVIDTELSFAEEKYGRAGQLEK 621

  Fly   882 TKCLKPNGNEIAVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELMAV 946
            ...|.|.|::|.||.||:..:::|..:...:..|....:.|.||..::....::.||...||..:
Frog   622 VVELIPGGSQILVTNENKVYYLNLLANHRLSNQVREEVDHFLKGLNELVPDNLLGIFDENELELL 686

  Fly   947 VVGN-----EDYDWQA--LQDNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIP 1004
            :.|.     :|:...|  :..:..:||      ..:.|||.|:..:::.|....|.|.|||.::|
Frog   687 MCGTGHIAVQDFQAHAVVIGGSWHFRE------KVMSWFWAVVSSLTQEELARLLQFTTGSSQLP 745

  Fly  1005 IQGMKALKLTIQ--PTPDERFLPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQ-TQGFSLV 1062
            ..|..||..:.|  .:|....||.||||||.|.||.|.:.|.:...|..||.: .:||.::
Frog   746 PGGFAALSPSFQIIGSPTHGTLPTAHTCFNQLCLPTYDSYEEMHKMLKLAISEGCEGFGML 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826
		RCC1	59..110	CDD:278826
		RCC1	114..163	CDD:278826
		RCC1	167..218	CDD:278826
		RCC1	221..270	CDD:278826	8/31 (26%)
		RCC1	273..322	CDD:278826	12/54 (22%)
		RCC1_2	309..339	CDD:290274	7/29 (24%)
		RCC1	327..390	CDD:278826	4/62 (6%)
		HECTc	715..1060	CDD:238033	97/377 (26%)
		HECTc	739..1059	CDD:214523	87/352 (25%)
arel1	NP_001011393.1	Filamin	56..153	CDD:366210	13/53 (25%)
arel1	NP_001011393.1	HECTc	447..804	CDD:238033	97/375 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910