DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Herc4 and nek8

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	XP_012812229.1	Gene:	nek8 / 448753	XenbaseID:	XB-GENE-990378	Length:	698	Species:	Xenopus tropicalis

Alignment Length:	388	Identity:	106/388 - (27%)
Similarity:	180/388 - (46%)	Gaps:	55/388 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LYCWGSTSHGQLGLGGIEDEQILTPSQIPWTPDTAVQQVACGHRHTLFLTATGKVYACGSNDYSQ 71
            :|.|||         ||.     ||.::|.. :|.|.||:.|......:|.:|::....:.....
Frog   322 VYTWGS---------GIS-----TPLRLPML-NTEVVQVSAGRTQKAGVTKSGRLIMWEATPVGT 371

  Fly    72 LGHDLPTK----RPR-MSPFLLIPELQDYVIIQ-ICCGSRHSLALSDWGQVLSWGDNDCGQLGHA 130
            ....||..    :|: :|.||   |.|..|.|: :.||...:..|:|.|.::::|....|.||||
Frog   372 GAPSLPGSIEHAQPQFISRFL---EGQSGVTIKHVSCGDLFTACLTDRGIIMTFGSGSNGCLGHA 433

  Fly   131 TDKEIVQLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGSNIYGQLGVNSPNDLTHCNYPL 195
            ...::.| ||:|..|:...:|.::||.:|::|:::..|::|||....|:||:.|....   |.|.
Frog   434 NFNDVTQ-PKIVEDLLGYEIVHVSCGASHAIAVSNEKEVFSWGRGDNGRLGLGSQESY---NSPQ 494

  Fly   196 RLTTLLGIPLAAIACGGNHSFLISKSGAVFGWGRNNCGQLGLN-----------DETNRSY---P 246
            ::..........:.||.:.|.:::.:..:...|.|...:||.:           |:...:|   |
Frog   495 QVIIPPEYEAQRVVCGIDSSMILTVANQLLACGSNRFNKLGFDRILSASEPSSEDQVEEAYTFTP 559

  Fly   247 TQLKTLRTLGVRFVACGDEFSVFLTNEGGVFTCGAGAYGQLGHGFSSNEMLPRMVMELMGSTITQ 311
            .|...|....:.....|...|..:|..|..:|.|:..:||||.....|..:|.:|..|.|..:|.
Frog   560 IQSAPLNQEAILCADVGTSHSAVVTALGQCYTFGSNQHGQLGTSAHRNSRVPCLVSALQGVKVTM 624

  Fly   312 VACGNRHTLALVPSRGRVYAFGLGSSGQLGTRSTKSLMLPQVVIGPWVSPSGSALLQSNDSQV 374
            ||||:.:|:| |.:.|:|:.:|.|:.|:||.|. :.:.:|::|           .|:.|.|.|
Frog   625 VACGDAYTVA-VGAEGQVFTWGKGARGRLGRRD-EGIGIPKIV-----------QLEENHSYV 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826	14/47 (30%)
		RCC1	59..110	CDD:278826	13/56 (23%)
		RCC1	114..163	CDD:278826	16/48 (33%)
		RCC1	167..218	CDD:278826	13/50 (26%)
		RCC1	221..270	CDD:278826	11/62 (18%)
		RCC1	273..322	CDD:278826	18/48 (38%)
		RCC1_2	309..339	CDD:290274	12/29 (41%)
		RCC1	327..390	CDD:278826	14/48 (29%)
		HECTc	715..1060	CDD:238033
		HECTc	739..1059	CDD:214523
nek8	XP_012812229.1	STKc_Nek8	3..258	CDD:270859
		S_TKc	4..256	CDD:214567
		ATS1	320..657	CDD:227511	100/358 (28%)
		RCC1	421..465	CDD:278826	15/44 (34%)
		RCC1	470..517	CDD:278826	13/49 (27%)
		RCC1	587..635	CDD:278826	19/48 (40%)
		RCC1	638..687	CDD:278826	14/49 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010