DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Herc4 and rcbtb2

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_001004950.1	Gene:	rcbtb2 / 448359	XenbaseID:	XB-GENE-952598	Length:	526	Species:	Xenopus tropicalis

Alignment Length:	305	Identity:	101/305 - (33%)
Similarity:	150/305 - (49%)	Gaps:	31/305 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 QVAC---GHRHTLFLTATGKVYACGSNDYSQLGHD-----LPTKRPRMSPFLLIPELQDYVIIQI 100
            |.||   .....|:||...:|:..|:|....||..     |..:|        |..|....|:.:
Frog    22 QQACVFGAGNEVLYLTKNDEVFVMGTNSSGCLGTGDAQSILEPRR--------IDMLSGKRIVSL 78

  Fly   101 CCGS-RHSLALSDWGQVLSWGDNDCGQLGHATDKEIVQLPKVVRQLVTKTVVQIACGNNHSLALT 164
            ..|| .|.:.::..|:|.|||.|...|||:.:..:.:...:|...|:.|..:.:|||::||:.||
Frog    79 SYGSGPHVVIVTSDGEVYSWGHNAYSQLGNGSTNQALSPCQVSTNLINKKAISVACGSHHSMVLT 143

  Fly   165 SCGELYSWGSNIYGQLGVNS------PNDLTHCNYPLRLTTLLGIPLAAIACGGNHSFLISKSGA 223
            ..||:|:||.|..||:|..|      |..:|.|   |:..|::|     ||||...|..:..:|.
Frog   144 CDGEVYAWGYNNSGQVGSGSTANQPIPRKVTSC---LQNKTVIG-----IACGQMSSMAVVDNGE 200

  Fly   224 VFGWGRNNCGQLGLNDETNRSYPTQLKTLRTLGVRFVACGDEFSVFLTNEGGVFTCGAGAYGQLG 288
            |:.||.|..|||||....|:..|.::..|:.:.|..|.||...::.||:||.::..||.:|||||
Frog   201 VYAWGYNGNGQLGLGSSGNQPTPCRIAALQGIRVEQVVCGYAHTLALTDEGVMYAWGANSYGQLG 265

  Fly   289 HGFSSNEMLPRMVMELMGSTITQVACGNRHTLALVPSRGRVYAFG 333
            .|..||:..|..|:......:...||.:.||.|.....|:||.:|
Frog   266 TGNKSNQSYPVQVIVDKERIVEIAACHSSHTSAAKSQSGQVYMWG 310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826	4/13 (31%)
		RCC1	59..110	CDD:278826	13/56 (23%)
		RCC1	114..163	CDD:278826	17/48 (35%)
		RCC1	167..218	CDD:278826	21/56 (38%)
		RCC1	221..270	CDD:278826	17/48 (35%)
		RCC1	273..322	CDD:278826	18/48 (38%)
		RCC1_2	309..339	CDD:290274	9/25 (36%)
		RCC1	327..390	CDD:278826	4/7 (57%)
		HECTc	715..1060	CDD:238033
		HECTc	739..1059	CDD:214523
rcbtb2	NP_001004950.1	ATS1	<17..269	CDD:227511	88/262 (34%)
		RCC1	250..298	CDD:366085	18/47 (38%)
		BTB_POZ	349..465	CDD:365784
		BACK_RCBTB2	462..526	CDD:350604
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010