DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Herc4 and hyd

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster

Alignment Length:	282	Identity:	80/282 - (28%)
Similarity:	130/282 - (46%)	Gaps:	17/282 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   794 TFETENMYFLIGVLCGLAIYNFTIINLPFPLALFKKLLGKPVDLSDLRQLSPPEANSMQSLLD-- 856
            :||..|.:..||.|.||.:....::.|.....:.|.:||:.:...||....|....|.:.::.
  Fly  2610 SFERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILGRKIKFHDLAFFDPALYESFRQIIQNA 2674

  Fly   857 --YQGDDFKEVFDLTFEISRDVFGE--AETKCLKPNGNEIAVTLENRQEFVDLYVDFVFNKSVEL 917
              .:|::.....:|.|.|  |:..|  ...:.|.|.|.::|||..|..|:|..|.::...||.|.
  Fly  2675 QTKEGEETINRMELCFVI--DLMKEEGCGNRELIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQEK 2737

  Fly   918 HYNAFHKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQALQD----NCEYREGYTSVDDTIKWF 978
            ...|...|...|.....:.....|:|..::.|..|.:...|..    |.|..||...:....|||
  Fly  2738 ALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINVSTLISYTTFNDESSEGPDKLLKFKKWF 2802

  Fly   979 WEVIHDMSEAEKKSFLLFLTGSDRIPI--QGMKAL-KLTIQPTPDERFLPVAHTCFNLLDLPRYK 1040
            |.::..|:..|::..:.|.|||..:|.  :|.:.| .:||:|. |:..||.|:||.:.|.:|.|.
  Fly  2803 WSIVEKMNIMERQDLVYFWTGSPALPASEEGFQPLPSVTIRPA-DDSHLPTANTCISRLYIPLYS 2866

  Fly  1041 TKERLKYKLLQAIQQTQGFSLV 1062
            :|..|:.|:|.|| :::.|..|
  Fly  2867 SKSILRSKMLMAI-KSKNFGFV 2887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826
		RCC1	59..110	CDD:278826
		RCC1	114..163	CDD:278826
		RCC1	167..218	CDD:278826
		RCC1	221..270	CDD:278826
		RCC1	273..322	CDD:278826
		RCC1_2	309..339	CDD:290274
		RCC1	327..390	CDD:278826
		HECTc	715..1060	CDD:238033	78/278 (28%)
		HECTc	739..1059	CDD:214523	78/277 (28%)
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769
		HECTc	2589..2885	CDD:238033	78/278 (28%)
		HECTc	2589..2884	CDD:214523	78/277 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446943
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830