DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Herc4 and Ube3a

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster

Alignment Length:	938	Identity:	253/938 - (26%)
Similarity:	400/938 - (42%)	Gaps:	217/938 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   286 QLGHGFSSNEMLPRMVMELMGSTITQVACGNRHTLALVPSRGRVYAFGLGSSGQLGTRSTKSLML 350
            ||...|:|....|:.|..|..:..:..:.|:..:.             :.|:....|.|.:|...
  Fly    92 QLCEAFTSEANSPQDVDMLSPNDSSSSSSGSSTST-------------ITSASTTTTTSRQSQST 143

  Fly   351 PQVVIGPWVSPSGSALLQSNDSQVSLVIRQIFSGGDQSIVTTTL--------------------- 394
            |..|:.|..||    .|..:..|:.:...: .|.||....|.||
  Fly   144 PAAVVVPVSSP----YLTQSVPQLDIAGAE-HSSGDSEPCTPTLAPVHSLDANSLIALYEQCRAA 203

  Fly   395 ---------------FVDKVPPEDFRNYNP------------------KSQILTLTAEVTK---Q 423
                           .||::.....|:..|                  |.|:.||..|..|   .
  Fly   204 DSYDRICHAIGVVFSSVDRLGKSFIRSAEPAASSSLQELLANSPGALNKEQLRTLEGEHDKDEDS 268

  Fly   424 CAQCKQGLQSDMDLLSSIELIFRSQA---------CWNGS--FLLD-------HDRHFGCSVR-- 468
            ..|..:..:|..:..::.|.: .|:|         |.:.|  .|:|       ....|||.:|
  Fly   269 TQQVDEQSESAANATATAESV-ESEAEPEEEDDDVCSSQSSDTLVDLPGLRRVQRLLFGCQIRAI 332

  Fly   469 NHGLDLKAAQLA--------------------FD-----NLRAVENESIRQV------------- 495
            ...|.....||:                    ||     |...|:.:.:.:|
  Fly   333 TEKLTSSVIQLSDWVIYMRTDWERVIHCLVICFDLATNTNNSVVDMDYLDRVLPKLCQAASAMPV 397

  Fly   496 --------IWDNITKELVGSLV--CSP-------ADVESMRLYLLLPLYHEFVNSKHYKSLQVPF 543
                    ||.....:.:.||:  |..       .|.||||       .:|.:.|. .|.|::.|
  Fly   398 PAQARLARIWAAHCSDQLHSLIAACQQQITLQVLLDEESMR-------ENESIISV-TKVLKIVF 454

  Fly   544 -ANAIFKLAENPRKVLNKWLAQTPAEYFEHLVQNFLHVVIHIISFKMGLAAASPSAERRQQLLPY 607
             ||.:....|.|.       .:.|.|                  .:...|.||.||.....|..|
  Fly   455 YANILASELERPS-------CRVPLE------------------DRTEAATASGSAAVEDDLFVY 494

  Fly   608 NTELEIIL------KLMKTLCQIN--NERHDRLNYQIFYWPDLSDYADVQQEYVKW--------I 656
            |:.||..:      :..|.| |::  :.|...:..:.||...||:...:..:|:.:        |
  Fly   495 NSLLEPHMPKFAEDQFEKEL-QVSAIDCRKPLIPLEEFYNEALSENIQMHHDYLSYKTLAMESEI 558

  Fly   657 MADTARDFNICNYSFIFDQSAKTALLQADQALQMHSAMANAATMAFSFFNYGMPISQ------FI 715
            .:..|..|:...|:||...|.|...|..|..::|:|...::   ..|..|....:.|      .:
  Fly   559 GSGHANYFSFMLYAFILTPSTKVDALYYDSRMRMYSERYSS---LHSILNNIGQVGQEDNPRPDL 620

  Fly   716 VLNVTRENLVQDSLRELQHYSQS---DLKKPLKIKFHGEEAEDAGGVRKEFFMLLLKDLLDPKYG 777
            .|.|.|:.|:.|:|..|:..:.|   ||||.|.::|.||:..|.|||.||||.|:::::.:|.:|
  Fly   621 KLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFG 685

  Fly   778 MFKEYEQSRLLWFADLTFETENMYFLIGVLCGLAIYNFTIINLPFPLALFKKLLGKPVDLSDLRQ 842
            ||.:.|::..:||....||....:.|||::.||||||...:.:.||:.:::||:|.....:||..
  Fly   686 MFIQQEETNNMWFNATPFENGAQFTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTFADLSD 750

  Fly   843 LSPPEANSMQSLLDYQGDDFKEVFDLTFEIS-RDVFGEAETKCLKPNGNEIAVTLENRQEFVDLY 906
            .||....|::|:|||||.|.:|||:.||:|| .||||:.....|.|||.::.|...|::.||:||
  Fly   751 WSPALYKSLKSMLDYQGQDMEEVFEQTFKISYSDVFGDVVQHELVPNGQDVLVGQHNKELFVNLY 815

  Fly   907 VDFVFNKSVELHYNAFHKGFMKVCSGRVIH-IFQPEELMAVVVGNEDYDWQALQDNCEYREGYTS 970
            .||:.|.::|..:|||.|||..|.....:. :|:|||:..:|.|:.::|:..|:::..|..|||.
  Fly   816 SDFLLNTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVCGSREFDFVELENSTVYEGGYTE 880

  Fly   971 VDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKALKLTI-QPTPDERFLPVAHTCFNLL 1034
            ....|:.||.::|.|...:|...|.|.|||.|:|:.|:|.|:|.| :..||...||.:|||||:|
  Fly   881 KSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCLRLLITRHGPDSDRLPTSHTCFNVL 945

  Fly  1035 DLPRYKTKERLKYKLLQAIQQTQGFSLV 1062
            .||.|.::|:|:.:|::||..::||.::
  Fly   946 LLPEYSSREKLEERLMKAINYSKGFGML 973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826
		RCC1	59..110	CDD:278826
		RCC1	114..163	CDD:278826
		RCC1	167..218	CDD:278826
		RCC1	221..270	CDD:278826
		RCC1	273..322	CDD:278826	8/35 (23%)
		RCC1_2	309..339	CDD:290274	2/29 (7%)
		RCC1	327..390	CDD:278826	14/62 (23%)
		HECTc	715..1060	CDD:238033	141/350 (40%)
		HECTc	739..1059	CDD:214523	132/322 (41%)
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166	1/1 (100%)
		HECTc	620..971	CDD:238033	141/350 (40%)
		HECTc	647..970	CDD:214523	132/322 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446934
Domainoid	1	1.000	187	1.000	Domainoid score	I755
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D15752at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm1192
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.750