DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Herc4 and CG3356

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster

Alignment Length:	735	Identity:	189/735 - (25%)
Similarity:	290/735 - (39%)	Gaps:	159/735 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   457 LDHDRHFGCSVRNHG-LDLKAAQLAFDNLRAVENESIRQVIWDNITKELVGSLVCSPADVESMRL 520
            ||:|....|  |..| |.:|..:...::: |:.||:.|.   |.|.::|      .|....:..:
  Fly   416 LDYDMEQTC--RTSGELSVKERECLLESI-AILNETERV---DFIVQQL------DPHIENTHLI 468

  Fly   521 YLLLPLYHE-FVNSKH----YKSLQV-----PFANAI-FKLAEN--------PRKVLNKWLAQ-- 564
            |.|..:.|. .:.:||    ||.|..     .|..|: ||||..        |..:::|.:..
  Fly   469 YALCEICHNLMIYNKHAVFEYKLLYTLAFTPKFIRAVWFKLAAESTQLGFSAPLTLISKGVVPKH 533

  Fly   565 --------------------TPAEYFEHLVQNFLHVVIH----------------------IISF 587
                                .|..:....|:|.|.:.:|                      :...
  Fly   534 QGVDRTIPLLATFCMLFGRLLPTLHDVEFVENKLLLQVHSTINHVRLMPFSIAEIIQMSKTLKDI 598

  Fly   588 KMGLA-AASPSAERRQQLLPYNTEL--------------EIILKLMKTLCQINNERHDRLNYQIF 637
            .|||. .|.|  |.|..|..|...|              :|...|:..:..:.|:.|.| :.::.
  Fly   599 SMGLVELAFP--ETRSNLANYRKVLGHTEADDKKLRHQKQIWANLLNVVVFVLNQIHTR-DLRLG 660

  Fly   638 YWP---------DL-----SDYADVQQEYVKWIMA-DTARDFN--------------------IC 667
            :.|         ||     :|........::.|.. ...|||.                    :.
  Fly   661 FCPEDHWTVTRLDLPLDRPTDLPLTHSSRLRGIRPFQPIRDFTREDFENGPPMSTKQIRSITILR 725

  Fly   668 NYSFIFDQSAKTALLQADQALQMHSAMANAATMAFSFFNYGMPISQFIVLNVTRENLVQDSLREL 732
            ...|:...:.:.::||:..|........|     ...|..|    ..:::.|.|.:|.:|:..:|
  Fly   726 EIPFVVPFNKRVSILQSLVAASKMRVQGN-----MQAFLQG----PSVLITVRRSHLYEDAYDKL 781

  Fly   733 QHYSQSDLKKPLKIKFHG-----EEAEDAGGVRKEFFMLLLKDLLDPKYGMF------KEYEQSR 786
            :..::.||:...:|:|..     |...|.|||.:||...|:|...||..|.|      |.|....
  Fly   782 RPDNEPDLRFKFRIQFVSSLGLDEAGIDGGGVFREFLSELIKTAFDPNRGFFMVTTDNKLYPNPN 846

  Fly   787 LLWFADLTFETENMYFLIGVLCGLAIYNFTIINLPFPLALFKKLLGK--PVDLSDLRQLSPPEAN 849
            :   |||..:.|..|:.||.:.|.:||...::.||.......||.||  .||:..|..|.|....
  Fly   847 V---ADLFEDYEKHYYFIGRILGKSIYENLLVELPLAEFFLTKLAGKYSDVDIHQLASLDPELYR 908

  Fly   850 SMQSLLDYQGDDFKEVFDLTFEISRDVFGEAETKCLKPNGNEIAVTLENRQEFVDLYVDFVFNKS 914
            ::..|.||.||  ....:|.|.::....|:.:...|||.|..|.||..||.|::.|..|:..|..
  Fly   909 NLLYLKDYSGD--VSELNLDFTVASSSLGQTQIVELKPQGQSIPVTNSNRIEYLQLIADYKLNVQ 971

  Fly   915 VELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVGNE-DYDWQALQDNCEYREGYTSVDDTIKWF 978
            :..|.|||.||...|.....:::|..:||..::.|.| ..|.:.|:.:|||...::....:|..|
  Fly   972 IRRHCNAFRKGLSNVLPIEWLYMFSNKELQILISGAEIPIDLEDLKKHCEYGGEFSPEHPSIVTF 1036

  Fly   979 WEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKAL--KLTIQPTPDERFLPVAHTCFNLLDLPRYKT 1041
            |||:....:.:::..|.|:|...|.|:.|.|.|  ...||.|.|...||.|.||.|||.||.:||
  Fly  1037 WEVLEGFDDMQRRQLLKFVTSCSRPPLLGFKDLDPPFFIQNTGDMERLPTASTCTNLLKLPPFKT 1101

  Fly  1042 KERLKYKLLQAIQQTQGFSL 1061
            .|:::.|||.|||...||.|
  Fly  1102 VEQMREKLLYAIQSGAGFEL 1121

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826
		RCC1	59..110	CDD:278826
		RCC1	114..163	CDD:278826
		RCC1	167..218	CDD:278826
		RCC1	221..270	CDD:278826
		RCC1	273..322	CDD:278826
		RCC1_2	309..339	CDD:290274
		RCC1	327..390	CDD:278826
		HECTc	715..1060	CDD:238033	120/360 (33%)
		HECTc	739..1059	CDD:214523	114/335 (34%)
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	120/358 (34%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	114/335 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446935
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740