DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Herc4 and Ube3a

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_001178766.1	Gene:	Ube3a / 361585	RGDID:	1306361	Length:	868	Species:	Rattus norvegicus

Alignment Length:	769	Identity:	222/769 - (28%)
Similarity:	383/769 - (49%)	Gaps:	128/769 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   377 VIRQIFSGGDQSIVTTTLFVDKVPPEDFRNYNPKSQILTLTAEVTKQCAQCKQGLQSDMDLLSSI 441
            ||.:|||.. :::|.:...|.:...|:.::...|.:.   ..|..|:.|.|......:....||.
  Rat   145 VIGRIFSSA-EALVQSFRKVKQHTKEELKSLQEKDED---KDEDEKEKAACSAAAMEEDSEASSS 205

  Fly   442 ELIFRSQACWNGSFLLDHDRHFGCSVRNHGLDLKAAQLAFDNLRAVENESIRQVIWDNITKE--- 503
            .:...||.                       |....:|..|:: .|:.::||:|....::.|
  Rat   206 RMGDSSQG-----------------------DNNVQKLGPDDV-TVDIDAIRRVYSSLLSDEKIE 246

  Fly   504 --LVGSLVCSPADVES--------------MRLYLLLPLYHEFVNSKHYKSLQVP-FANAIFKL- 550
              .:.:||....:||.              :.|:::: :.:..::|..|..:.:| |..|:.||
  Rat   247 TAFLNALVYLSPNVECDLTYHNVYTRDPNYLNLFIIV-MENRNLHSPEYLEMALPLFCKAMSKLP 310

  Fly   551 --AENPRKVLNKWLAQTPAEYFEHLVQNFLHVVIH-IISFKM----------GLAAASP------ 596
              |:.  |::..| ::..|:....:::.|..::.: :||.:.          .:.|||.
  Rat   311 LAAQG--KLIRLW-SKYSADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVY 372

  Fly   597 -------------SAERRQQLLPYNTELEIILKL--------------------MKTL-CQINNE 627
                         :.|..::.:|.::||.:...|                    :||| |
  Rat   373 YANVVGGDVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLETEIGVKTLDC----- 432

  Fly   628 RHDRLNYQIFYWPDLSDYADVQQEYVKWIMADTARDFNICNYSFIFDQSAKTALLQADQALQMHS 692
            |...::::.|....|:|..::.::|. :...:|...|:.....||.:...|...|..|..::|:|
  Rat   433 RKPLISFEEFINEPLNDVLEMDKDYT-FFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYS 496

  Fly   693 AMANAATMAFSFFNYGMPISQFIVLNVTRENLVQDSLRELQHYSQ---SDLKKPLKIKFHGEEAE 754
              ....|:.:|... |..::.::.|.|.|::::.|:|..|:..:.   :||||.|.::|.||:..
  Rat   497 --ERRITVLYSLVQ-GQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGV 558

  Fly   755 DAGGVRKEFFMLLLKDLLDPKYGMFKEYEQSRLLWFADLTFETENMYFLIGVLCGLAIYNFTIIN 819
            |.|||.||||.|:::::.:|..|||...|.:||.||...:||||..:.|||::.||||||..|::
  Rat   559 DEGGVSKEFFQLVVEEIFNPDIGMFTYDEATRLFWFNPSSFETEGQFTLIGIVLGLAIYNNCILD 623

  Fly   820 LPFPLALFKKLLGKPVDLSDLRQLSPPEANSMQSLLDYQG---DDFKEVFDLTFEISR-DVFGEA 880
            :.||:.:::||:||.....||....|....|::.||:|:|   ||..    :||:||: |:||..
  Rat   624 VHFPMVVYRKLMGKKGTFCDLGDSHPILYQSLKDLLEYEGNVEDDMM----ITFQISQTDLFGNP 684

  Fly   881 ETKCLKPNGNEIAVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVI-HIFQPEELM 944
            ....||.||::|.:|.|||:|||.||.|::.|||||..:.||.:||..|.:...: ::|:|||:.
  Rat   685 MMYDLKENGDKIPITNENRKEFVSLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIE 749

  Fly   945 AVVVGNEDYDWQALQDNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMK 1009
            .::.|:.:.|:|||::..||..|||.....|:.|||::|..::.:|:.||.|.||:||.|:.|:.
  Rat   750 LLICGSRNLDFQALEETTEYDGGYTRESVVIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLG 814

  Fly  1010 ALKLTIQPT-PDERFLPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGFSLV 1062
            .||:.|... ||...||.:|||||:|.||.|.:||:||.:||:||...:||.::
  Rat   815 KLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGML 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826
		RCC1	59..110	CDD:278826
		RCC1	114..163	CDD:278826
		RCC1	167..218	CDD:278826
		RCC1	221..270	CDD:278826
		RCC1	273..322	CDD:278826
		RCC1_2	309..339	CDD:290274
		RCC1	327..390	CDD:278826	5/12 (42%)
		HECTc	715..1060	CDD:238033	148/353 (42%)
		HECTc	739..1059	CDD:214523	141/325 (43%)
Ube3a	NP_001178766.1	AZUL	27..81	CDD:406862
Ube3a	NP_001178766.1	HECTc	516..866	CDD:238033	148/353 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276447at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820