DRSC/TRiP Functional Genomics Resources

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Protein Alignment Herc4 and Hecw2

DIOPT Version :9

Sequence 1:NP_001261249.1 Gene:Herc4 / 38151 FlyBaseID:FBgn0035207 Length:1062 Species:Drosophila melanogaster
Sequence 2:NP_001001883.1 Gene:Hecw2 / 329152 MGIID:2685817 Length:1578 Species:Mus musculus


Alignment Length:364 Identity:118/364 - (32%)
Similarity:189/364 - (51%) Gaps:29/364 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly   717 LNVTRENLVQDSLRELQHYSQSDLKK-PLKIKFHGEEAEDAGGVRKEFFMLLLKDLLDPKYGMFK 780
            |.:.|::|::|:..::..||:.||:: .|.:.|.|||..|..|..:|||.|:.::|.:|.||:| 
Mouse  1224 LIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLF- 1287

  Fly   781 EY--------EQSRLLWFADLTFETENMYFLIGVLCGLAIYNFTIINLPFPLALFKKLLGKPVDL 837
            ||        :.|.:..|.|...|   .:...|.:.|||:.:..:::..|....:|.||....||
Mouse  1288 EYSANDTYTVQISPMSAFVDNHHE---WFRFSGRILGLALIHQYLLDAFFTRPFYKALLRILCDL 1349

  Fly   838 SDLRQLSPPEANSMQSLLDYQGDDFKEVFDLTFEISRDVFGEAETKCLKPNGNEIAVTLENRQEF 902
            |||..|......|:|.:.|   :|..::.||||.::.:|||:...:.|||.|..|.||.:|::|:
Mouse  1350 SDLEYLDEEFHQSLQWMKD---NDIHDILDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEY 1411

  Fly   903 VDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQALQDNCEYREG 967
            ::..|.:...:.|.....:..:||.:|...|::.:|...||..|:.|..:.|....::|.|||.|
Mouse  1412 IERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGG 1476

  Fly   968 YTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKALKLTIQPTPDERF--------- 1023
            |......|:|||..:...:..::...|.|:||:..||.:|..:|:.:..|   .||         
Mouse  1477 YHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGP---RRFCVEKWGKIT 1538

  Fly  1024 -LPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGFSL 1061
             ||.||||||.||||.|.:...|..|||.|:::|..|.|
Mouse  1539 ALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGL 1577

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Herc4NP_001261249.1 RCC1 6..55 CDD:278826
RCC1 59..110 CDD:278826
RCC1 114..163 CDD:278826
RCC1 167..218 CDD:278826
RCC1 221..270 CDD:278826
RCC1 273..322 CDD:278826
RCC1_2 309..339 CDD:290274
RCC1 327..390 CDD:278826
HECTc 715..1060 CDD:238033 116/361 (32%)
HECTc 739..1059 CDD:214523 110/338 (33%)
Hecw2NP_001001883.1 HECW_N 45..164 CDD:374632
C2_NEDL1-like 185..320 CDD:176073
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 341..453
DMP1 <344..700 CDD:369294
NESP55 <463..639 CDD:115071
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 496..802
Interaction with TP73. /evidence=ECO:0000250 737..1074
WW 815..844 CDD:366073
HECW1_helix 921..987 CDD:375862
WW 993..1022 CDD:366073
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1030..1075
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1167..1193
HECTc 1222..1576 CDD:238033 116/361 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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