DRSC/TRiP Functional Genomics Resources

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Protein Alignment Herc4 and smurf1

DIOPT Version :9

Sequence 1:NP_001261249.1 Gene:Herc4 / 38151 FlyBaseID:FBgn0035207 Length:1062 Species:Drosophila melanogaster
Sequence 2:NP_001001943.1 Gene:smurf1 / 321695 ZFINID:ZDB-GENE-040426-2744 Length:731 Species:Danio rerio


Alignment Length:378 Identity:128/378 - (33%)
Similarity:198/378 - (52%) Gaps:55/378 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   717 LNVTRENLVQDSLRELQHYSQSDLKKPLKIKFHGEEAEDAGGVRKEFFMLLLKDLLDPKYGMFKE 781
            :.|:||.:.::|.|::......||||.|.:||.|||..|.|||.:|:..||..::|:|.||:|: 
Zfish   375 IEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQ- 438

  Fly   782 YEQSRLLWFADLTFETENMYFL------------------IGVLCGLAIYNFTIINLPFPLALFK 828
                         :.|:|:|.|                  :|.:.|||:::...||..|.|..:|
Zfish   439 -------------YSTDNIYTLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTLPFYK 490

  Fly   829 KLLGKPVDLSDLRQLSPPEANSMQSLLDYQGDDFKEVFDLTFEISRDVFGEAETKCLKPNGNEIA 893
            :|||||:.|.||..:.|....|:..:|:   :|...|.|.||.:..:.||:.....|||||..|.
Zfish   491 QLLGKPIQLCDLETVDPELHKSLVWILE---NDITSVLDHTFCVEHNAFGKFLQHELKPNGKNIP 552

  Fly   894 VTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELMAVV--VGNEDY-DW 955
            ||.||::|:|.|||::.|.:.:|..:.|..|||.::....::..|..:||..::  :|..|. ||
Zfish   553 VTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDNKELELIIGGLGKIDLNDW 617

  Fly   956 QALQDNCEYREGYTSVDDTI-KWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKALKLTIQPTP 1019
            :|     ..|..:...|..| ||||:.:....|..:...|.|:|||.|:|:||.|||:.:.....
Zfish   618 KA-----NTRLKHCVADSNIVKWFWQAVESFDEERRGRLLQFVTGSTRVPLQGFKALQGSTGSAG 677

  Fly  1020 DERF-----------LPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGFSL 1061
            ...|           ||.||||||.:|:|.|::.|:|..|||.|:::|.||::
Zfish   678 PRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 730

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Herc4NP_001261249.1 RCC1 6..55 CDD:278826
RCC1 59..110 CDD:278826
RCC1 114..163 CDD:278826
RCC1 167..218 CDD:278826
RCC1 221..270 CDD:278826
RCC1 273..322 CDD:278826
RCC1_2 309..339 CDD:290274
RCC1 327..390 CDD:278826
HECTc 715..1060 CDD:238033 127/375 (34%)
HECTc 739..1059 CDD:214523 121/352 (34%)
smurf1NP_001001943.1 C2_Smurf-like 14..138 CDD:176028
WW 234..266 CDD:197736
WW 280..312 CDD:197736
HECTc 373..728 CDD:238033 126/374 (34%)
HECTc 397..728 CDD:214523 121/352 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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