DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Herc4 and CG42797

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster

Alignment Length:	1081	Identity:	226/1081 - (20%)
Similarity:	384/1081 - (35%)	Gaps:	302/1081 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 GDNDCGQLGHATDKEIVQLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGSNIYGQL---- 180
            |....|..|.||...:|..|...........:|....|:   :|.|.|.:.|....:..||
  Fly   508 GGAGAGATGGATGSPLVCPPTPTHHARRHARLQAVTANS---SLASGGAIPSDPPAVSSQLDYIY 569

  Fly   181 --------GVNSPNDLTHCNYPLRLTTLLGIP-------LAAIACGGNHSFLISKSGAVFG---- 226
                    |....:::.|    :..|.|..||       .||.|.....:.:...:|.|.|
  Fly   570 LQDGGQEQGQEQSDEVVH----ISSTRLPSIPERSAAAAAAAAAAAAGAALMEPGTGTVSGSSGA 630

  Fly   227 -----------W--GRNNCGQLGLNDETNRSYPTQLKTLRTLGVRFVACGDEFSVFLTNEGGVFT 278
                       |  ..::.|::...|.|.|:...|..
  Fly   631 GAAGEPPLPPAWEARMDSHGRIFYIDHTTRTTSWQRP---------------------------- 667

  Fly   279 CGAGAYGQLGHGFSSNEMLPRMVMELMGSTITQVACGNRHTLALVPSRGRVYAFGLGSSGQLGTR 343
             ||...|    |.:..|...|..::....:|       |.|:.......::|  .|.:|......
  Fly   668 -GAAPSG----GPAGREQHHRQQLDRRYQSI-------RRTITNESRAAQLY--NLPTSANSNAN 718

  Fly   344 ST-KSLMLPQVVIGPWV----SPSGSALLQSNDSQVSLVIRQIFSGGDQSIVTTTLFVDKVPPED 403
            || .:...|...|.|.:    .|...:||.:|::.:::
  Fly   719 STAPAAPPPATAIHPAILMLCRPDFYSLLHTNEAALAI--------------------------- 756

  Fly   404 FRNYNPKSQILTLTAEVTKQCAQCKQGLQSDMDLLSSIELIFRSQ----ACW-------NGSFLL 457
               ||..:.:..:...:.:. ..|.|..|.:.||::.:....:..    :||       ...|.:
  Fly   757 ---YNRNAALKHMVMRIRRD-PPCFQRYQYNKDLVALVNTFAQMSRELPSCWETKLDQSGKQFFI 817

  Fly   458 DHDRHFGCSVRNHGLDLKAAQLAFDNLRAVENESIRQ---------VIWDNITKELVGSLVCSPA 513
            || :|...|..:..|.::..::    :|..:..|.:|         ::..|......|.:..|||
  Fly   818 DH-QHRRTSFMDPRLPVECPRV----VRHRQQHSQQQSSVGYYYPDLVDGNCLSATSGHINASPA 877

  Fly   514 DVES----------------------------------------MRLYLLLPLYHEFVNSKHYKS 538
            ...|                                        ...|....:......:..|:.
  Fly   878 SSVSGVPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMASAGATAAGYED 942

  Fly   539 LQVPFANAIFKLAENPR--KVLNKWLAQTPAEYFEHLVQNFLHVVIHIISFKMGLAAASPSAERR 601
            :.:.:...:......|.  ::|.:...|       |.:...|...|:|:..:     ..|:.||
  Fly   943 VPIAYNEKVIAFLRQPNILEILRERQGQ-------HTMSRQLREKINILRVE-----GVPALER- 994

  Fly   602 QQLLPYNTELEIILKLMKTLCQINNERHDRLNYQIFYWPDLSDYADVQQEYVKWIMADTARDFNI 666
               |.::.:|.|:|.|.                              :||              |
  Fly   995 ---LGHDLQLTILLSLF------------------------------EQE--------------I 1012

  Fly   667 CNYSFIFDQSAKTALLQADQALQMHSAMANAATMAF---------SFF------NYGMPISQFIV 716
            ..:..|.::|.:.:.:       ::|.|...|...|         ||:      .||....: :.
  Fly  1013 MGFVPIEERSPQGSPV-------LNSRMPQRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHK-LK 1069

  Fly   717 LNVTRENLVQDSLRELQHYSQSDLKK-PLKIKFHGEEAEDAGGVRKEFFMLLLKDLLDPKYGMFK 780
            |::.|.:|::|:.|.:...::.||:: .|.:.:..||..|.||..:|||.||.::|.:|.||:|
  Fly  1070 LHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLF- 1133

  Fly   781 EY--------EQSRLLWFADLTFETENMYFLIGVLCGLAIYNFTIINLPFPLALFKKLLGKPVDL 837
            ||        :.|.|..|.|   ...:.:...|.:.|||:.:..:::..|....:|.||..||.|
  Fly  1134 EYSANDTYTVQVSPLSAFVD---NCHDWFRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLPVAL 1195

  Fly   838 SDLRQLSPPEANSMQSLLDYQGDDFKEVFD--LTFEISRDVFGEAETKCLKPNGNEIAVTLENRQ 900
            |||..|......|:|.:.|   :|.....|  |||.::.::.|....:.|||.|..|.:..:|::
  Fly  1196 SDLESLDNEFHQSLQWIRD---NDIGTGVDLGLTFCVTEELLGSVVDRELKPGGKNIIINEKNKK 1257

  Fly   901 EFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQALQDNCEYR 965
            |:::..:.:...:.|:....:..:||.:|...|::.:|...||..|:.|..:.|....:.|.|||
  Fly  1258 EYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGTAEIDTNDWRLNTEYR 1322

  Fly   966 EGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKALKLTIQPTPDERF------- 1023
            .||......|.|||:||...|..::...|.|:||:..||.:|..||:.:..|   .||
  Fly  1323 SGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTGP---RRFCIEKWGK 1384

  Fly  1024 ---LPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGFSL 1061
               ||.||||||.||||.|.|.|.|..|||.|:::|..|.:
  Fly  1385 PNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNTFGI 1425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826
		RCC1	59..110	CDD:278826
		RCC1	114..163	CDD:278826	9/42 (21%)
		RCC1	167..218	CDD:278826	13/69 (19%)
		RCC1	221..270	CDD:278826	9/65 (14%)
		RCC1	273..322	CDD:278826	9/48 (19%)
		RCC1_2	309..339	CDD:290274	6/29 (21%)
		RCC1	327..390	CDD:278826	12/67 (18%)
		HECTc	715..1060	CDD:238033	117/365 (32%)
		HECTc	739..1059	CDD:214523	112/340 (33%)
CG42797	NP_572574.2	WW	638..667	CDD:278809	6/28 (21%)
		HECTc	1068..1424	CDD:238033	117/365 (32%)
		HECTc	1092..1423	CDD:214523	112/340 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446939
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740