DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Herc4 and Herc4

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_001012074.1	Gene:	Herc4 / 309758	RGDID:	1310971	Length:	1057	Species:	Rattus norvegicus

Alignment Length:	1079	Identity:	481/1079 - (44%)
Similarity:	671/1079 - (62%)	Gaps:	45/1079 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LYCWGSTSHGQLGLGGIEDEQILTPSQIPWTPDTAVQQVACGHRHTLFLTATGKVYACGSNDYSQ 71
            :.|||:.|:||||||||::|.:|.|.:..:..:..|:.|.||.|||:|:...|.||.||.||..|
  Rat     1 MLCWGNASYGQLGLGGIDEEIVLEPRKSDFFVNKKVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQ 65

  Fly    72 LGHDLPTKRPRMSPFLLIPELQDYVIIQICCGSRHSLALSDWGQVLSWGDNDCGQLGHATDKEIV 136
            |||:...|:|..     :..|....|:.:.||..|:|||:|.|||.:||.:..||||....:|.:
  Rat    66 LGHEKSRKKPEQ-----VVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLQGSEECI 125

  Fly   137 QLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGSNIYGQLGVNSPNDLTHC---NYPLRLT 198
            ::|:.::.|....:||:|||..|||||:...|::.||.|.|||||:.     ..|   ..|..:.
  Rat   126 RVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLG-----IECQKQTSPQLIK 185

  Fly   199 TLLGIPLAAIACGGNHSFLISKSGAVFGWGRNNCGQLGLNDETNRSYPTQLKTLRTLGVRFVACG 263
            :|||||...:|.||.|||:::.|||:||||||..||||||||.:|..|..||:||:..:.::.||
  Rat   186 SLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCG 250

  Fly   264 DEFSVFLTNEGGVFTCGAGAYGQLGHGFSSNEMLPRMVMELMGSTITQVACGNRHTLALVPSRGR 328
            ::.:..||.||||||.|||.||||||..:|:|:.||.|.|||||.:||:|||.:||.|.|||.||
  Rat   251 EDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQIACGRQHTSAFVPSSGR 315

  Fly   329 VYAFGLGSSGQLGTRSTKSLMLPQVVIGPWVSPSGSALLQSNDSQVSLVIRQIFSGGDQSIVTTT 393
            :|:||||.:|||||.||.:...|..|.|.|.|.:|.. .|...|:....:::||||||||....:
  Rat   316 IYSFGLGGNGQLGTGSTSNRKSPFTVKGNWFSYNGQC-PQDIGSEDYFCVKRIFSGGDQSFSHYS 379

  Fly   394 LFVDKVPPEDFRNYNPKSQILTLTAEVTKQCAQCKQGLQSDMDLLSSIELIFRSQACWNGSFL-L 457
            ......||:|||..:|..||.|:...:.::......| :..:::.:.|:..|.|..|.||||| :
  Rat   380 SPQSCGPPDDFRRSDPSKQIWTVNEALIQKWLSYPSG-RFPVEIANEIDGTFSSSGCLNGSFLAV 443

  Fly   458 DHDRHFGCSVRNHGLDLKAAQLAFDNLRAVENESIRQVIWDNITKELVGSLVCSPADVESMRLYL 522
            .:|.|:....|..|:|:.||:|.|..|...::..|.|.:..::.|.|:..|..|..|||::|.||
  Rat   444 SNDDHYRTGTRFSGVDMNAARLLFHRLIQPDHPQISQQVAASLEKNLIPKLTSSLPDVEALRFYL 508

  Fly   523 LLPLYHEFVNSKHYKSLQVPFANAIFKLAENPRKVLNKWLAQTPAEYFEHLVQNFLHVVIHIIS- 586
            .||......:..::.::.:||..|:..|.:.|.|||..|.:......|..:|:.|..||:|::.
  Rat   509 TLPECPLMSDCNNFTTIAIPFGTALVNLEKAPLKVLENWWSVLEPPLFLKIVELFKEVVVHLLKL 573

  Fly   587 FKMGLAAASPSAERRQQLLPYNTELEIILKLMKTLCQINNERHDRLNYQIFYWPDLSDYADVQQE 651
            :|:|:    |.:|||    .:|:.|...||:::.|.::|......:.|..||..::.:..|::.:
  Rat   574 YKIGI----PPSERR----IFNSFLHTALKVLEILHRVNERTGQLIQYDKFYIHEVQELIDIRND 630

  Fly   652 YVKWI---------------MADTARDFNICNYSFIFDQSAKTALLQADQALQMHSAM--ANAAT 699
            |:.|:               :||.  ...||.|.|:||..|||.|||.|..|||..|:  |:...
  Rat   631 YINWVQQQAYGVDVSHGITELADI--PVTICTYPFVFDAQAKTTLLQTDAVLQMQMAIDQAHRQN 693

  Fly   700 MAFSFFNYGMPISQFIVLNVTRENLVQDSLRELQHYSQSDLKKPLKIKFHGEEAEDAGGVRKEFF 764
            ::..|......::..::|.|.|||:|.|::..|:.....|.|||||:.|.||:|.||||||||||
  Rat   694 VSSLFLPVIESVNPCLILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFF 758

  Fly   765 MLLLKDLLDPKYGMFKEYEQSRLLWFADLTFETENMYFLIGVLCGLAIYNFTIINLPFPLALFKK 829
            :|::::|||||||||:.||.|||:||:|.|||..:::.||||:||||||||||::|.|||||:||
  Rat   759 LLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSDLFHLIGVICGLAIYNFTIVDLHFPLALYKK 823

  Fly   830 LLGKPVDLSDLRQLSPPEANSMQSLLDYQGDDFKEVFDLTFEISRDVFGEAETKCLKPNGNEIAV 894
            ||.:...|.||::|.|....|||.||||..||.:|.|.|.|.|:.:.||..|.|.|..||.:.||
  Rat   824 LLKRKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAV 888

  Fly   895 TLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQALQ 959
            ..:|||||||.|||::|||||...::|||.||.|||.|:|:.:|||.||.|:|:||.:|||:.|:
  Rat   889 NKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELE 953

  Fly   960 DNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKALKLTIQPT-PDERF 1023
            .|.||:..|.:...|||.||||.|::...:||.|||||||||||||.|||:|||.||.| ..|.:
  Rat   954 KNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGESY 1018

  Fly  1024 LPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGFSLV 1062
            |||:||||||||||:|..||.|:.||:|||...:||||:
  Rat  1019 LPVSHTCFNLLDLPKYTEKETLRCKLIQAIDHNEGFSLI 1057

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826	22/47 (47%)
		RCC1	59..110	CDD:278826	19/50 (38%)
		RCC1	114..163	CDD:278826	20/48 (42%)
		RCC1	167..218	CDD:278826	22/53 (42%)
		RCC1	221..270	CDD:278826	25/48 (52%)
		RCC1	273..322	CDD:278826	32/48 (67%)
		RCC1_2	309..339	CDD:290274	18/29 (62%)
		RCC1	327..390	CDD:278826	30/62 (48%)
		HECTc	715..1060	CDD:238033	199/345 (58%)
		HECTc	739..1059	CDD:214523	190/320 (59%)
Herc4	NP_001012074.1	RCC1 1	1..51		23/49 (47%)
		RCC1	3..49	CDD:278826	22/45 (49%)
		RCC1 2	52..101		17/48 (35%)
		RCC1	52..99	CDD:278826	17/46 (37%)
		RCC1 3	102..154		21/51 (41%)
		RCC1	102..152	CDD:278826	21/49 (43%)
		RCC1 4	156..207		20/53 (38%)
		RCC1	157..205	CDD:278826	18/50 (36%)
		RCC1 5	208..259		28/50 (56%)
		RCC1	208..257	CDD:278826	26/48 (54%)
		RCC1	260..308	CDD:278826	29/47 (62%)
		RCC1 6	261..311		32/49 (65%)
		RCC1 7	313..366		26/52 (50%)
		RCC1	313..>343	CDD:278826	19/29 (66%)
		HECTc	709..1055	CDD:238033	200/346 (58%)
		HECTc	735..1054	CDD:214523	190/319 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	355	1.000	Domainoid score	I958
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56715
Inparanoid	1	1.050	904	1.000	Inparanoid score	I359
OMA	1	1.010	-	-		QHG57432
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	1	1.000	-	-		FOG0001110
OrthoInspector	1	1.000	-	-		otm45366
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45622
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X678
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.080