DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Herc4 and Rccd1

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	XP_006229517.1	Gene:	Rccd1 / 308760	RGDID:	1309901	Length:	378	Species:	Rattus norvegicus

Alignment Length:	315	Identity:	79/315 - (25%)
Similarity:	123/315 - (39%)	Gaps:	97/315 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SGKELYCW--GSTSHGQLGLGGIEDEQILTPSQIP-WTPDTAVQQVACGHRHTLFLTATGKVYAC 64
            ||.||..|  ||...|:                 | |     ||.:|.|.:
  Rat    93 SGTELQAWVPGSALQGE-----------------PLW-----VQNLASGAK-------------- 121

  Fly    65 GSNDYSQLGHDLPTKRPRMSPFLLIPELQDYV---------------IIQICCGSRHSLALSDWG 114
                  ..|.|.|...|||....|:|..:.|:               :.|:..|:.|:|.|.:.|
  Rat   122 ------AQGEDEPGSEPRMGTLPLLPCARAYMTPQPPFCQPLAPELRVRQLQLGAEHALLLCEAG 180

  Fly   115 QVLSWGDNDCGQLGHATDKEIVQLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGSNIYGQ 179
            ||.|||....|||||.:.:..:: |:::..|....:.::|.|..||:.::..|::|.||.|..||
  Rat   181 QVFSWGGGRHGQLGHGSLEAELE-PRLLEALQGLRMAEVAAGGWHSVCVSETGDIYIWGWNESGQ 244

  Fly   180 LGVNSPN---------DLTHCN-------------------------YPLRLTTLLGIPLAAIAC 210
            |.:.:.:         :.|..|                         :|..|...||......:|
  Rat   245 LALPTRSGTEKKTVREEATELNDDGLRGEEAALADVGAPAHFIAIQPFPALLDLPLGSDAVKASC 309

  Fly   211 GGNHSFLISKSGAVFGWGRNNCGQLGLNDETNRSYPTQLKTL--RTLGVRFVACG 263
            |..|:.:::::|.::.||....||||..|.|:...|.:::..  |.|.||.|.||
  Rat   310 GSRHTAVVTRTGELYTWGWGKYGQLGHKDSTSSDQPCRVEYFVERQLEVRAVTCG 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826	12/51 (24%)
		RCC1	59..110	CDD:278826	13/65 (20%)
		RCC1	114..163	CDD:278826	17/48 (35%)
		RCC1	167..218	CDD:278826	17/84 (20%)
		RCC1	221..270	CDD:278826	17/45 (38%)
		RCC1	273..322	CDD:278826
		RCC1_2	309..339	CDD:290274
		RCC1	327..390	CDD:278826
		HECTc	715..1060	CDD:238033
		HECTc	739..1059	CDD:214523
Rccd1	XP_006229517.1	RCC1_2	163..192	CDD:290274	11/28 (39%)
		RCC1	180..228	CDD:278826	17/48 (35%)
		RCC1_2	218..244	CDD:290274	9/25 (36%)
		RCC1_2	305..333	CDD:290274	6/27 (22%)
		RCC1	321..368	CDD:278826	17/44 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920