DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Herc4 and Nek9

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_001100217.2	Gene:	Nek9 / 299204	RGDID:	1307187	Length:	976	Species:	Rattus norvegicus

Alignment Length:	328	Identity:	93/328 - (28%)
Similarity:	153/328 - (46%)	Gaps:	53/328 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 PTKRPRMS-----PFLLIPELQDYVII---------------------QICCGSRHSLALSDWGQ 115
            ||||||.|     |..::......|.:                     |:|.|:.|...::...:
  Rat   324 PTKRPRSSTVTEAPIAVVTSRTSEVYVWGGGKSTPQKLDVIKSGCSARQVCAGNTHFAVVTVEKE 388

  Fly   116 VLSW-----GDNDCGQLGHATDKEIVQLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGSN 175
            :.:|     |....|||||. ||...:.||.|.:|..|.:.|::||::.::.:|..|:||::||:
  Rat   389 LYTWVNMQGGTKLHGQLGHG-DKASYRQPKHVEKLQGKAIHQVSCGDDFTVCVTDEGQLYAFGSD 452

  Fly   176 IYGQLG---VNSPNDLTHCNYPLRLTTLLGIPLAAIACGGNHSFLISKSGAVFGWGRNNCGQLGL 237
            .||.:|   |:.|..|.    |::|...|..|:..::||.||..:::::..|:.||....|:|||
  Rat   453 YYGCMGVDKVSGPEVLE----PMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGL 513

  Fly   238 NDETNRSYPTQLKTLRTLGVRFVACGDEFSVFLTNEGGVFTCGAGAYGQLG-----HGFSSNEM- 296
            :.|.:...|.::...:.|.:..|.||.:.:..||..|.|..||...:.:||     .|..::|.
  Rat   514 DSEEDYYTPQRVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAY 578

  Fly   297 --LP-----RMVMELMGSTITQVACGNRHTLALVPSRGRVYAFGLGSSGQLGTRSTKSLMLPQVV 354
              :|     .:..:|....|..:|.|..|| |.:..|||:..||....||||..:.|..:...::
  Rat   579 HEVPYTTSFTLAKQLSFYKIRTIAPGKTHT-AAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLL 642

  Fly   355 IGP 357
            .||
  Rat   643 GGP 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826
		RCC1	59..110	CDD:278826	13/58 (22%)
		RCC1	114..163	CDD:278826	17/53 (32%)
		RCC1	167..218	CDD:278826	19/53 (36%)
		RCC1	221..270	CDD:278826	13/48 (27%)
		RCC1	273..322	CDD:278826	15/61 (25%)
		RCC1_2	309..339	CDD:290274	11/29 (38%)
		RCC1	327..390	CDD:278826	11/31 (35%)
		HECTc	715..1060	CDD:238033
		HECTc	739..1059	CDD:214523
Nek9	NP_001100217.2	STKc_Nek9	50..297	CDD:270860
Nek9	NP_001100217.2	ATS1	344..687	CDD:227511	85/308 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920