Protein Alignment Herc4 and Arel1

DIOPT Version :9

• Sequence 1: NP_001261249.1
• Gene: Herc4 / 38151
• FlyBaseID: FBgn0035207
• Length: 1062
• Species: Drosophila melanogaster
• Sequence 2: NP_001100214.1
• Gene: Arel1 / 299197
• RGDID: 1307597
• Length: 823
• Species: Rattus norvegicus
• Alignment Length: 637
• Identity: 143/637 - (22%)
• Similarity: 247/637 - (38%)
• Gaps: 142/637 - (22%)

  Fly   516 ESMRLYLLLPL-----YHEFVNSKHYKSLQVPFANA---IFKLAENPRKVLNKWLAQTPAE-YFE 571
            ::.:::|.|.|     :|..::.::.     |..|.   |..|:||.:.::.:.::.:... |||
  Rat   239 QTCQVFLRLTLHSRGCFHACISYQNQ-----PINNGEFDIIVLSENEKNIVERNVSTSGVSIYFE 298

  Fly   572 HLVQN---FLHVVIHIISFKMGLAAASPSA--ERRQQLLPYNTEL-EIILKLMKTLCQINNERHD 630
            ..:.|   :.....|:....|..:...||.  |..::..|..... |.:.|..|..|.::.::.
  Rat   299 AYLYNANSYSSAPWHLPPMHMSSSQRRPSTALEEEEEDSPSECHTPEKVKKPKKVYCYVSPKQF- 362

  Fly   631 RLNYQIFYWPDLSDYADVQQEYVKWIMADTARDFNIC---NYSFIF-DQSAKTALLQADQALQ-- 689
                            .|::.|:| |:......|.:|   .:|::. |...|...|..|..:|
  Rat   363 ----------------SVKEFYLK-IIPWRLYTFRVCPGTKFSYLGPDPVHKLLTLVVDDGIQPP 410

  Fly   690 ------------------MHSAMANAATM--AFSFFNYGM-------PISQFIVLNVTRENLVQD 727
                              :|..:..:.|.  ..:||...:       |.|: :.|.|:|..|::.
  Rat   411 VELSCKERNILAATFIRSLHKNIGGSETFQDKVNFFQRELRQVHMKRPHSK-VTLKVSRHALLES 474

  Fly   728 SLRELQHYSQSDLKKPLKIKFHGEEAEDAGGVRKEFFMLLLKDLLDPKYGMFKEYEQSRLLWFAD 792
            ||:..:::|.||..|..::.|..|||.|.||.|:|:|.|:.|.|.|....:|..:..:.    ..
  Rat   475 SLKATRNFSISDWSKNFEVVFQDEEALDWGGPRREWFELICKALFDTTSQLFTRFSDNN----QA 535

  Fly   793 LTFETEN--------MYFLIGVLCGLAIYNFT-------IINLPFPLALFKKLLGKPVDLSDLR- 841
            |.....|        ||...|.|.|..:|..:       ::...|..:...:::|       ||
  Rat   536 LVHPNPNRPAHLRLKMYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIG-------LRM 593

  Fly   842 -----QLSPPEANSMQSLLDYQGDDFKEVFDLTFEISRDVFGEAETKC-----------LKPNGN 890
                 :...||.        |:.   |..|.|..::|......||.|.           |...|.
  Rat   594 HYKYFETDDPEF--------YKS---KVCFILNNDMSEMELVFAEEKYNKSGQLDKIVELMTGGA 647

  Fly   891 EIAVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVGNEDY-- 953
            :..||..|:..:::|...:.....|:.....|.||..::....::.||...||..::.|..|.
  Rat   648 QTPVTNANKTFYLNLLAQYRLASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISV 712

  Fly   954 -DWQA----LQDNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKAL-- 1011
             |::|    :..:..:||      ..::|||.|:..:::.|....|.|.|||.::|..|..||
  Rat   713 SDFKAHAVVVGGSWHFRE------KVMRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCP 771

  Fly  1012 KLTIQPTPDERFLPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQ-TQGFSLV 1062
            ...|...|....||.||||||.|.||.|.:.|.:...|..||.: .:||.::
  Rat   772 SFQIIAAPTHSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGFGML 823

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826
		RCC1	59..110	CDD:278826
		RCC1	114..163	CDD:278826
		RCC1	167..218	CDD:278826
		RCC1	221..270	CDD:278826
		RCC1	273..322	CDD:278826
		RCC1_2	309..339	CDD:290274
		RCC1	327..390	CDD:278826
		HECTc	715..1060	CDD:238033	100/386 (26%)
		HECTc	739..1059	CDD:214523	91/361 (25%)
Arel1	NP_001100214.1	Filamin	56..154	CDD:395505
		HECTc	486..820	CDD:214523	91/361 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900