DRSC/TRiP Functional Genomics Resources

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Protein Alignment Herc4 and Hecw1

DIOPT Version :9

Sequence 1:NP_001261249.1 Gene:Herc4 / 38151 FlyBaseID:FBgn0035207 Length:1062 Species:Drosophila melanogaster
Sequence 2:XP_017455974.1 Gene:Hecw1 / 291209 RGDID:1561038 Length:1603 Species:Rattus norvegicus


Alignment Length:371 Identity:115/371 - (30%)
Similarity:184/371 - (49%) Gaps:39/371 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   715 IVLNVTRENLVQDSLRELQHYSQSDLKK-PLKIKFHGEEAEDAGGVRKEFFMLLLKDLLDPKYGM 778
            |.|.:.|::|::.:..::..||:.:|:: .|.|.|.|||..|..|..:|||.||.::|.:|.||:
  Rat  1247 IKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYITFVGEEGLDYSGPSREFFFLLSQELFNPYYGL 1311

  Fly   779 FKEYE----------------QSRLLWFADLTFETENMYFLIGVLCGLAIYNFTIINLPFPLALF 827
            | ||.                ::.|.||.           ..|.:.|||:.:..:::..|....:
  Rat  1312 F-EYSANDTYTVQISPMSAFVENYLEWFR-----------FSGRILGLALIHQYLLDAFFTRPFY 1364

  Fly   828 KKLLGKPVDLSDLRQLSPPEANSMQSLLDYQGDDFKEVFDLTFEISRDVFGEAETKCLKPNGNEI 892
            |.||..|.|||||..|......|:|.:.|   ::..::.||||.::.:|||:...:.||..|...
  Rat  1365 KGLLKLPCDLSDLEYLDEEFHQSLQWMKD---NNITDILDLTFTVNEEVFGQVTERELKSGGANT 1426

  Fly   893 AVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQA 957
            .||.:|::|:::..|.:...:.|.....|..:||.:|...|::.:|...||..|:.|..:.|...
  Rat  1427 QVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLND 1491

  Fly   958 LQDNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKAL-------KLTI 1015
            .::|.|||.||......|:|||..:...:..::...|.|:||:..:|.:|..||       :..|
  Rat  1492 WRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCI 1556

  Fly  1016 QPTPDERFLPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGFSL 1061
            :.......||.||||||.||||.|.:...|..|||.|:::|..|.|
  Rat  1557 EKWGKITSLPRAHTCFNRLDLPPYPSYSTLYEKLLTAVEETSTFGL 1602

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Herc4NP_001261249.1 RCC1 6..55 CDD:278826
RCC1 59..110 CDD:278826
RCC1 114..163 CDD:278826
RCC1 167..218 CDD:278826
RCC1 221..270 CDD:278826
RCC1 273..322 CDD:278826
RCC1_2 309..339 CDD:290274
RCC1 327..390 CDD:278826
HECTc 715..1060 CDD:238033 113/368 (31%)
HECTc 739..1059 CDD:214523 107/343 (31%)
Hecw1XP_017455974.1 HECW_N 66..185 CDD:293170
C2_NEDL1-like 206..342 CDD:176073
WW 827..857 CDD:197736
WW 1017..1048 CDD:197736
HECTc 1247..1601 CDD:238033 113/368 (31%)
HECTc 1271..1600 CDD:214523 107/343 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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