DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Herc4 and HECTD1

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_056197.3	Gene:	HECTD1 / 25831	HGNCID:	20157	Length:	2610	Species:	Homo sapiens

Alignment Length:	490	Identity:	109/490 - (22%)
Similarity:	174/490 - (35%)	Gaps:	176/490 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   722 ENLVQDSLRELQHYSQSDLKKPLKIKFHGEEAEDAGGVRKEFFMLLLKDLLDPKYGMFKEYEQSR 786
            ||::|         ..:|.|..|:::|.|||....|.. .||:.|:.           .|::::.
Human  2146 ENVMQ---------IHADRKSVLEVEFLGEEGTGLGPT-LEFYALVA-----------AEFQRTD 2189

  Fly   787 L-LWFADLTFETE----------------------------------------NMYFLIGVLCGL 810
            | .|..|..|..:                                        .::..:|:....
Human  2190 LGAWLCDDNFPDDESRHVDLGGGLKPPGYYVQRSCGLFTAPFPQDSDELERITKLFHFLGIFLAK 2254

  Fly   811 AIYNFTIINLPFPLALFKKLLGKPV--DLSDL-------RQLSPPEANSMQS------------- 853
            .|.:..:::||.....||.:....:  ::|.|       |.|...|:.|..|
Human  2255 CIQDNRLVDLPISKPFFKLMCMGDIKSNMSKLIYESRGDRDLHCTESQSEASTEEGHDSLSVGSF 2319

  Fly   854 --------LLD---------YQG----DDF-----------KEVFDLTFE---------ISRDVF 877
                    :||         :.|    :||           ||:.||..:         :|.|
Human  2320 EEDSKSEFILDPPKPKPPAWFNGILTWEDFELVNPHRARFLKEIKDLAIKRRQILSNKGLSED-- 2382

  Fly   878 GEAETK---------------------------C------------LKPNGNEIAVTLENRQEFV 903
             |..||                           |            |||:|.:..:|::|.:|:|
Human  2383 -EKNTKLQELVLKNPSGSGPPLSIEDLGLNFQFCPSSRIYGFTAVDLKPSGEDEMITMDNAEEYV 2446

  Fly   904 DLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQALQDNCEYRE-- 966
            ||..||..:..::....||..||.||.....:..|..||:..::.||:...| |.:|...|.|
Human  2447 DLMFDFCMHTGIQKQMEAFRDGFNKVFPMEKLSSFSHEEVQMILCGNQSPSW-AAEDIINYTEPK 2510

  Fly   967 -GYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKAL--KLTIQPTPD--ERFLPV 1026
             |||........|..|:..||..|:|:||.|.||...:|..|:..|  :||:....|  :...|.
Human  2511 LGYTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKVDATDASYPS 2575

  Fly  1027 AHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGFSL 1061
            .:||.:.|.||.|.::|.::.:||.|..: :||.|
Human  2576 VNTCVHYLKLPEYSSEEIMRERLLAATME-KGFHL 2609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826
		RCC1	59..110	CDD:278826
		RCC1	114..163	CDD:278826
		RCC1	167..218	CDD:278826
		RCC1	221..270	CDD:278826
		RCC1	273..322	CDD:278826
		RCC1_2	309..339	CDD:290274
		RCC1	327..390	CDD:278826
		HECTc	715..1060	CDD:238033	107/487 (22%)
		HECTc	739..1059	CDD:214523	103/469 (22%)
HECTD1	NP_056197.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	246..269
		Ank_2	366..457	CDD:403870
		ANK repeat	366..393	CDD:293786
		ANK 1	395..424
		ANK repeat	396..426	CDD:293786
		ANK 2	426..455
		ANK repeat	428..457	CDD:293786
		ANK 3	459..491
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	489..513
		ANK 4	579..612
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	627..657
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	707..748
		Sad1_UNC	1107..1240	CDD:400199
		MIB_HERC2	1277..1335	CDD:399589
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1343..1406
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1433..1483
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1496..1515
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1592..1611
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1674..1757
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1777..1797
		BTHB	1892..1965	CDD:408209
		K-box	2029..2103
		HECTc	2131..2608	CDD:238033	107/487 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2297..2318		3/20 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900