DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Herc4 and Plekha5

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_647556.1	Gene:	Plekha5 / 246237	RGDID:	621175	Length:	1281	Species:	Rattus norvegicus

Alignment Length:	630	Identity:	120/630 - (19%)
Similarity:	193/630 - (30%)	Gaps:	237/630 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   386 DQSIVTTTLFVDKVPPEDFRNYNPKSQILTLTAEVTKQCAQCKQGLQSDMDLLSSIELIFRSQAC 450
            ||::.:.......||...::.::|:.   |..:||:                 |.|:
  Rat   541 DQTMHSIPTSPSHVPAAAYQGFSPQR---TYRSEVS-----------------SPIQ-------- 577

  Fly   451 WNGSFLLD------HDRHFGCSVRNHGLDLKAAQLAFDNLRAVENESIRQVIWDNITKELVGSLV 509
             .|...:|      |.:|.....|..    ..|.||   |:||..:|:.....:.:|..|: .|.
  Rat   578 -RGDVTIDRRHRPHHPKHVYVPDRRS----MPAGLA---LQAVSPQSLHGRTPEELTLLLI-KLR 633

  Fly   510 CSPADVESMRLYLLLPLY---------------HEFVNSKHYKSLQV----PFANAIFKLAENPR 555
            ...|::.|:|.:.|..|.               |....:..|...|:    |....:..:.||.
  Rat   634 RQQAELSSIREHTLAQLMQLKLEAHSPKNEILSHHLQRNTIYLDHQMKENEPIITMVHTMIENS- 697

  Fly   556 KVLNKWLAQTPAEYFEHLVQNFLHVVIHIISFKMGLAAASPSAERRQQLLPYN-TELEIILKLMK 619
                   |..|..|.:.|.|          ..|:.|...|.. |.|..|..|. .|::|..||.:
  Rat   698 -------ALRPQLYQQFLRQ----------KNKISLYCLSQD-ECRGTLYKYRPEEVDIDAKLSR 744

  Fly   620 TLCQIN------NERHDRLNYQIFYWPDLSDYADVQQEYV---KWIMADTARDFNICNYSFIFDQ 675
             ||:.:      .|:..:|:               :::|.   ..:.|....:.|..|.:.|
  Rat   745 -LCEQDKVVRALEEKLQQLH---------------KEKYTLEQALLSASQEIEMNADNPAAI--- 790

  Fly   676 SAKTALLQAD----------QALQMHSAMANAATMAFSFFNYGMPISQFIVLNVTRENLVQDSLR 730
              :|.:||.|          :.|...:|....|...:....|.        :.||| |.:||.|.
  Rat   791 --QTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYD--------VTVTR-NQMQDQLD 844

  Fly   731 ELQHYSQSDLKKPLKIKFHGEEAEDAGGVRKEFFMLLLKDLLDPKYGMFKEYEQSRLLWFADLTF 795
            .|                 ||...::.|:::......|..:.|...|:.|..:|..       :.
  Rat   845 RL-----------------GEVQSESAGIQRAQIQKELWRIQDVMEGLSKHKQQRG-------SS 885

  Fly   796 ETENMYFLIGVLCGLAIYNFTIINLPFPLALFKK----------LLGKPVDLSDLRQLSPPEANS 850
            ||           |||...      |||...:|.          .|.:..|.::...:.||..:.
  Rat   886 ET-----------GLAGPK------PFPAVKYKSEEEEVVPPRPPLPRSYDFTEQPPIIPPLPSD 933

  Fly   851 MQSLLDYQ-------------------------GDDFK------------EVFDLTFEISRDVFG 878
            ..|||.|.                         |.|::            ||.:...|...:...
  Rat   934 SSSLLCYSRGPVHLPEEKKSHQVQGYPRNGSHCGPDYRLYKSEPELTTVAEVDESNGEEKSEPAS 998

  Fly   879 EAE----------------TKCLKPNGNEIA--VTLENRQEFVDL 905
            |||                ||...|..:.||  |||...::.|:|
  Rat   999 EAEAPVVRGSHFPVGVPLRTKSPTPESSTIASYVTLRKTKKMVEL 1043

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826
		RCC1	59..110	CDD:278826
		RCC1	114..163	CDD:278826
		RCC1	167..218	CDD:278826
		RCC1	221..270	CDD:278826
		RCC1	273..322	CDD:278826
		RCC1_2	309..339	CDD:290274
		RCC1	327..390	CDD:278826	2/3 (67%)
		HECTc	715..1060	CDD:238033	51/256 (20%)
		HECTc	739..1059	CDD:214523	43/232 (19%)
Plekha5	NP_647556.1	WW	13..42	CDD:278809
		WW	59..88	CDD:278809
		PH_PEPP1_2_3	165..268	CDD:270068
		PH	171..267	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900