DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Herc4 and Herc1

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	XP_006511166.1	Gene:	Herc1 / 235439	MGIID:	2384589	Length:	4885	Species:	Mus musculus

Alignment Length:	1090	Identity:	279/1090 - (25%)
Similarity:	442/1090 - (40%)	Gaps:	294/1090 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GK-ELYCWGSTSHGQLGLGGIEDEQILTPSQIPWTPDTAVQQVACGHRHTLFLTATGKVYACGSN 67
            || ::|.||:..||||...|   ..::.|:..|  ..:..|||.||...|..:.|.|.|.|||..
Mouse  4019 GKCDVYLWGAGRHGQLAEAG---RNVMVPATAP--SFSQAQQVICGQNCTFVIQANGTVLACGEG 4078

  Fly    68 DYSQLGH----DLPTKRPRMSPFLLIPELQDYVIIQI--CCGS-RHSLALSDWGQVLSWGDNDCG 125
            .|.:||.    ||..       ..:|..||.:|:.|:  .||| .||:||::.|:|.||||.|.|
Mouse  4079 SYGRLGQGNSDDLHV-------LTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYG 4136

  Fly   126 QLGHA-TDKEIVQLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGSNIYGQLGV-NSPNDL 188
            :|||. :|::  :.|:.:..|..:.|||::||..||..:||.|:|:::|:..||:||: |:.|.
Mouse  4137 KLGHGNSDRQ--RRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNK- 4198

  Fly   189 THCNYPLRLTTLLGIPLAAIACGGNHSFLISKSGA-VFGWGRNNCGQLGLNDETNRSYPTQLKTL 252
               ..|.|:|.|.|..:..:|||.||:..:|..|: |:.:|..:.|:|||.:.|.:|.|.::..|
Mouse  4199 ---KLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKVDVL 4260

  Fly   253 RTLGVRFVACGDEFSVFLTNEGGVFTCGAGAYGQLGHGFSSNEMLPRMVMELMGSTITQVACGNR 317
            ..:|::.||||.:|||.||.:|.|:|.|......|..|.:.|...|:.:..|.|..|..||.|..
Mouse  4261 CGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVVIEDVAVGAE 4325

  Fly   318 HTLALVPSRGRVYAFGLGSSGQLGTRSTKSLMLPQVVIGPWVSPSGSALLQSNDSQVSLVIRQIF 382
            |||||. |.|.|||:|..|.||||...|..:..|.:|          .:||..:      ||||.
Mouse  4326 HTLALA-STGDVYAWGSNSEGQLGLGHTNHVREPTLV----------TVLQGKN------IRQIS 4373

  Fly   383 SGGDQSIVTTTLFVDKVPPEDFRNYNPKSQILTLTAEVTKQCAQCKQGLQSDMDLLSSIELIFRS 447
            :|...|...|   ...|||
Mouse  4374 AGRCHSAAWT---APPVPP---------------------------------------------- 4389

  Fly   448 QACWNGSFLLDHDRHFGCSVRNHGLDLKAAQLAFDNLRAVENESIRQVIWDNITKELVGSLVCSP 512
                         |..|.||        ..||...:....:..::|:|
Mouse  4390 -------------RAPGVSV--------PLQLGLPDAVPPQYGALREV----------------- 4416

  Fly   513 ADVESMRLYLLLPLYHEFVNSKHYKSLQVPFANAIFKLAENPRKVLNKWLAQTPAEYFEHLVQNF 577
             .:.::|..|.| |||              |::.::    :..::||             |..|.
Mouse  4417 -SIHTVRARLRL-LYH--------------FSDLMY----SSWRLLN-------------LSPNN 4448

  Fly   578 LHVVIHIISFKMGLAAASPSAERRQQLLPYNTELEIILKLMKTLCQINNERHDRLNYQIFYWPDL 642
            .:...|..:...|:.    ..:.|..|.|....|.::..:.||:.|..|           |.|.:
Mouse  4449 QNSTSHYNAGTWGIV----QGQLRPLLAPRVYTLPMVRSIGKTMVQGKN-----------YGPQI 4498

  Fly   643 SDYADVQQEYVKWIMADTARDFNICNYSFIFDQSAKTALLQADQALQMHSAMANAATMAFSFFNY 707
            :         ||.|.....:    |..  ||.|.|:
Mouse  4499 T---------VKRISTRGRK----CKP--IFVQIAR----------------------------- 4519

  Fly   708 GMPISQFIVLNVTRENLVQDSLRELQHYSQSDLKKP---LKIKFHGEEAEDAGGVRKEFFMLL-- 767
                 |.:.||.                  |||:.|   .|:|..||.|:|||||..:....:
Mouse  4520 -----QVVKLNA------------------SDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQ 4561

  Fly   768 -----LKDLLDPKYGMFKE--YEQSRLLWFADLTFETENMYF-LIGVLCGLAIYNFTIINLPFPL 824
                 :.|||.|......|  |.:.|.|:......:...|.| .:|:|.|:||.....::|....
Mouse  4562 ELETGIVDLLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAP 4626

  Fly   825 ALFKKLLGKPVDLSDLRQLSPPEANSMQSLLDYQG-----DDFKEVFDLTFEISRDVFGEAETKC 884
            .::|:|...|:.|.||.::......::.|:|..:.     :.|.|:..|...:.:...|:...
Mouse  4627 LVWKQLCCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMVP-- 4689

  Fly   885 LKPNGNEIAVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVG 949
            :.|.||.|.:|..||:|:|:..:::..:: ::....|..:|...:....::.:...::|..:|.|
Mouse  4690 IIPGGNSIPLTFSNRKEYVERAIEYRLHE-MDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCG 4753

  Fly   950 NEDYDWQALQDNCEYREGYTSVDD---TIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPI------ 1005
            ..:.....|:....|||    ||:   .::|.|..:.:.|..|:..|:.|::|..|:|.
Mouse  4754 MPEICVDVLKKVVRYRE----VDEQHQLVQWLWRTLEEFSNEERVLFMRFVSGRSRLPANTADIS 4814

  Fly  1006 QGMKALKLTIQPTPDERF--LPVAHTCFNLLDLPRYKTK----ERLKYKL 1049
            |..:.:|:      |..:  ||.:.|||..|.||.|.::    |||:|.:
Mouse  4815 QRFQIMKV------DRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAI 4858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826	16/48 (33%)
		RCC1	59..110	CDD:278826	20/57 (35%)
		RCC1	114..163	CDD:278826	21/49 (43%)
		RCC1	167..218	CDD:278826	19/51 (37%)
		RCC1	221..270	CDD:278826	19/49 (39%)
		RCC1	273..322	CDD:278826	17/48 (35%)
		RCC1_2	309..339	CDD:290274	16/29 (55%)
		RCC1	327..390	CDD:278826	21/62 (34%)
		HECTc	715..1060	CDD:238033	89/368 (24%)
		HECTc	739..1059	CDD:214523	86/344 (25%)
Herc1	XP_006511166.1	ATS1	374..731	CDD:227511
		SPRY_HERC1	2039..2196	CDD:293939
		UBA_HERC1	2760..2803	CDD:270584
		WD40	3448..3799	CDD:392136
		WD40 repeat	3456..3499	CDD:293791
		WD40 repeat	3513..3548	CDD:293791
		WD40 repeat	3610..3648	CDD:293791
		WD40 repeat	3653..3689	CDD:293791
		WD40 repeat	3697..3736	CDD:293791
		WD40 repeat	3774..3810	CDD:293791
		ATS1	4022..4370	CDD:227511	138/382 (36%)
		HECTc	4497..4865	CDD:238033	98/442 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920