DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Herc4 and Plekha7

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	XP_017177675.1	Gene:	Plekha7 / 233765	MGIID:	2445094	Length:	1359	Species:	Mus musculus

Alignment Length:	268	Identity:	53/268 - (19%)
Similarity:	95/268 - (35%)	Gaps:	84/268 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   431 LQSDMDLLSSIELIFRSQACWNGSFLLDHDRHF-GCSVRNHGLDLKAAQLAFDNLRAVENESIRQ 494
            ||.....|:|:......|       ||.|...| .|...:..|.|| ..|.:.:|:...||.:..
Mouse   659 LQRHQSKLASVRNFAVGQ-------LLHHYLTFPACQADDTYLQLK-KDLEYLDLKIKNNEPLIN 715

  Fly   495 VIWDNITKELVGSLVCSPADVESMRLYLLLPLYHEFVNSKHYKSLQVPFANAIFKLA-------- 551
            |::..:.|...|   |.|....:.|         :.:..:..|.:::..::...||:
Mouse   716 VLYKVLKKSARG---CRPGRSMTGR---------DLLKDRSLKPMKIAESDIDVKLSIFCEQDRI 768

  Fly   552 ------------------ENPRKVLNKWLAQ--TPAEYFEHLV--QNFLHV-VIHIISFKMGLAA 593
                              |:..:||::...|  ...::.|.:.  |..|.. ::||
Mouse   769 LQDLEDKIRALKENKDQLESVLEVLHRQTEQYRDQPQHLEKITCQQRLLQEDLVHI--------- 824

  Fly   594 ASPSAERRQQLLPYNTELE----IILKLMKTLCQIN---NERHDRLNYQIFYWPDLSDYADVQQE 651
                   |.:|...:||:|    ..|||.|.:.|:.   .|:|.|    .|::.:.|   .:|::
Mouse   825 -------RAELCRESTEMENAWNEYLKLEKDVEQLKQTLQEQHRR----AFFFQEKS---QIQKD 875

  Fly   652 YVKWIMAD 659
            .  |.:.|
Mouse   876 L--WRIED 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826
		RCC1	59..110	CDD:278826
		RCC1	114..163	CDD:278826
		RCC1	167..218	CDD:278826
		RCC1	221..270	CDD:278826
		RCC1	273..322	CDD:278826
		RCC1_2	309..339	CDD:290274
		RCC1	327..390	CDD:278826
		HECTc	715..1060	CDD:238033
		HECTc	739..1059	CDD:214523
Plekha7	XP_017177675.1	WW	10..39	CDD:366073
		WW	55..84	CDD:366073
		PH_PEPP1_2_3	158..280	CDD:270068
		Smc	<692..>894	CDD:224117	43/228 (19%)
		PHA03247	<903..1009	CDD:223021
		PRK10263	<912..>1118	CDD:236669
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900