DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Herc4 and HECW1

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	XP_016867371.1	Gene:	HECW1 / 23072	HGNCID:	22195	Length:	1639	Species:	Homo sapiens

Alignment Length:	371	Identity:	114/371 - (30%)
Similarity:	184/371 - (49%)	Gaps:	39/371 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   715 IVLNVTRENLVQDSLRELQHYSQSDLKK-PLKIKFHGEEAEDAGGVRKEFFMLLLKDLLDPKYGM 778
            |.|.:.|::|::.:..::..||:.:|:: .|.:.|.|||..|..|..:|||.||.::|.:|.||:
Human  1283 IKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGL 1347

  Fly   779 FKEYE----------------QSRLLWFADLTFETENMYFLIGVLCGLAIYNFTIINLPFPLALF 827
            | ||.                ::.|.||.           ..|.:.|||:.:..:::..|....:
Human  1348 F-EYSANDTYTVQISPMSAFVENHLEWFR-----------FSGRILGLALIHQYLLDAFFTRPFY 1400

  Fly   828 KKLLGKPVDLSDLRQLSPPEANSMQSLLDYQGDDFKEVFDLTFEISRDVFGEAETKCLKPNGNEI 892
            |.||..|.|||||..|......|:|.:.|   ::..::.||||.::.:|||:...:.||..|...
Human  1401 KALLRLPCDLSDLEYLDEEFHQSLQWMKD---NNITDILDLTFTVNEEVFGQVTERELKSGGANT 1462

  Fly   893 AVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQA 957
            .||.:|::|:::..|.:...:.|.....|..:||.:|...|::.:|...||..|:.|..:.|...
Human  1463 QVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLND 1527

  Fly   958 LQDNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKAL-------KLTI 1015
            .::|.|||.||......|:|||..:...:..::...|.|:||:..:|.:|..||       :..|
Human  1528 WRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCI 1592

  Fly  1016 QPTPDERFLPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGFSL 1061
            :.......||.||||||.||||.|.:...|..|||.|:::|..|.|
Human  1593 EKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGL 1638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826
		RCC1	59..110	CDD:278826
		RCC1	114..163	CDD:278826
		RCC1	167..218	CDD:278826
		RCC1	221..270	CDD:278826
		RCC1	273..322	CDD:278826
		RCC1_2	309..339	CDD:290274
		RCC1	327..390	CDD:278826
		HECTc	715..1060	CDD:238033	112/368 (30%)
		HECTc	739..1059	CDD:214523	106/343 (31%)
HECW1	XP_016867371.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810