DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Herc4 and Hectd2

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_001156943.1	Gene:	Hectd2 / 226098	MGIID:	2442663	Length:	775	Species:	Mus musculus

Alignment Length:	790	Identity:	239/790 - (30%)
Similarity:	368/790 - (46%)	Gaps:	91/790 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   317 RHTLALVPSRGRVYAFGLGSSGQLGTRST--KSLMLPQVVIGPWVSPSGSALLQSNDSQ----VS 375
            |..|..:.:.|.......||.||:.|.|:  .::...:.......||:..||....:.:    :.
Mouse    31 REKLPPIVTAGAAAGLDRGSKGQISTFSSFVSTVTQKKEAAENRSSPTHLALPNIRNVRDLPPIC 95

  Fly   376 LVIRQIFSGGDQSIVTTTLFVD-KVPP-------------EDFRNYNPKSQILTLTAEVTKQCAQ 426
            |.:||     .|.:....|..: ||||             :||.....|       ||.|.....
Mouse    96 LDVRQ-----KQRMSVEALPSEVKVPPLPEPSLPSQPKTVKDFEEDLEK-------AEATGNWKT 148

  Fly   427 CKQGLQSDMDLLSSIELIFRSQACWNGSFLLDHDRHFGCSVRNHGLDLKAAQLAFDNLRAVENES 491
            ......:..|..:.:...|:..|  ..||         .::.:.||:.......||.|.     :
Mouse   149 VHAFYITAFDSFTELNTAFKKDA--TASF---------NTIEDSGLNANLVNAVFDALL-----N 197

  Fly   492 IRQVIWDNITKELVGSLV---CSPADVESMRLYLLLPLYHEFVNSKHYKSLQVPFANAIFKLA-- 551
            ..|.|..::.|.::.||:   ..|...:.:|.|.:|....:|    :..|..|.:|:.:.::|
Mouse   198 TPQDIQKSVLKGIINSLLQEWKGPRTKDDLRAYFILLQNPQF----NITSTYVIYAHLLRQIATL 258

  Fly   552 -ENPRKVLNKWLAQTPAEYFEHLVQNFLHVVIHIISFKMGLAAASPSAERRQQLLPYNTELEIIL 615
             |.....|..||.:...:.|:.||:..|..|      .:.|..|.|  |....|......:....
Mouse   259 VEADHHFLVHWLKKLSQKKFKQLVERLLQFV------SLRLFPAKP--EEFPPLTKCTWWIPSAA 315

  Fly   616 KLMKTLCQINNERHDRL-NYQIFYWPDLSDYADVQQEYVKW-IMADTARDFNICNYSFIFDQSAK 678
            |::..|...||..|..| .|..||...| |:.|:.:||..| ...::...|:.|.|.|:...:||
Mouse   316 KVLALLNTANNLVHPPLVPYTDFYNSTL-DHIDLMEEYHTWQSFGNSHSRFSFCQYPFVISIAAK 379

  Fly   679 TALLQADQALQMHSAMANAATMAFSFFNYGMPISQFIVLN--VTRENLVQDSLRELQHYSQSDLK 741
            ..::|.|...||.|....:.....|  ....|....:.||  |.|.:||.|||.||.. .::|||
Mouse   380 KIIIQRDSEQQMISIARQSLVDKVS--RRQRPDMNMLFLNMKVRRTHLVSDSLDELTR-KRADLK 441

  Fly   742 KPLKIKFHGEEAEDAGGVRKEFFMLLLKDLLDPKYGMFKEYEQSRLLWFADLTFETENMYFLIGV 806
            |.||:.|.||...|.||:.||:|:||::.:..|.||||..::.|...||:....:..:.:.|:|:
Mouse   442 KKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMFTYHKDSHCHWFSSFKCDNYSEFRLVGI 506

  Fly   807 LCGLAIYNFTIINLPFPLALFKKLLGKP--------------VDLSDLRQLSPPEANSMQSLLDY 857
            |.|||:||...:::.||...:||||..|              |.:.||.|:.|..|:.::.||.|
Mouse   507 LMGLAVYNSITLDIRFPPCCYKKLLSPPVVPSDQSTPVGICSVTIDDLCQVMPELAHGLKELLSY 571

  Fly   858 QGDDFKEVFDLTFEISRDVFGEAETKCLKPNGNEIAVTLENRQEFVDLYVDFVFNKSVELHYNAF 922
            :| :.:|.|..||::.::.||..::..|||.|::|.||.:||:|:|.||.||:.|||:...:.||
Mouse   572 EG-NVEEDFYSTFQVFQEEFGVIKSYNLKPGGDKIPVTNQNRREYVQLYTDFLLNKSIYKQFAAF 635

  Fly   923 HKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQALQDNCEYREGYTSVDDTIKWFWEVIHDMSE 987
            :.||..||:...:.:.:|||:..:|.|:.:.|..|||.:.:| :||...|.||::||:|:.....
Mouse   636 YCGFHSVCASNALMLLRPEEVEILVCGSPELDMHALQRSTQY-DGYAKTDLTIRYFWDVVLGFPL 699

  Fly   988 AEKKSFLLFLTGSDRIPIQGMKALKLTIQPT-PDERFLPVAHTCFNLLDLPRYKTKERLKYKLLQ 1051
            ..:|..|.|.|||||:|:.||..|...|... ....:|||||||||.|.||.||:|:.||.||:.
Mouse   700 ELQKKLLHFTTGSDRVPVGGMADLNFKISKNETSTNWLPVAHTCFNQLCLPPYKSKKDLKQKLII 764

  Fly  1052 AIQQTQGFSL 1061
            .|..::||.|
Mouse   765 GISNSEGFGL 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826
		RCC1	59..110	CDD:278826
		RCC1	114..163	CDD:278826
		RCC1	167..218	CDD:278826
		RCC1	221..270	CDD:278826
		RCC1	273..322	CDD:278826	2/4 (50%)
		RCC1_2	309..339	CDD:290274	5/21 (24%)
		RCC1	327..390	CDD:278826	15/68 (22%)
		HECTc	715..1060	CDD:238033	143/361 (40%)
		HECTc	739..1059	CDD:214523	131/334 (39%)
Hectd2	NP_001156943.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51		4/19 (21%)
		HECTc	416..773	CDD:238033	143/359 (40%)
		HECTc	439..772	CDD:214523	131/334 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276447at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R774
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850