Protein Alignment Herc4 and Hectd2

DIOPT Version :10

• Sequence 1: NP_001261249.1
• Gene: Herc4 / 38151
• FlyBaseID: FBgn0035207
• Length: 1062
• Species: Drosophila melanogaster
• Sequence 2: NP_001156943.1
• Gene: Hectd2 / 226098
• MGIID: 2442663
• Length: 775
• Species: Mus musculus
• Alignment Length: 790
• Identity: 239/790 - (30%)
• Similarity: 368/790 - (46%)
• Gaps: 91/790 - (11%)

  Fly   317 RHTLALVPSRGRVYAFGLGSSGQLGTRST--KSLMLPQVVIGPWVSPSGSALLQSNDSQ----VS 375
            |..|..:.:.|.......||.||:.|.|:  .::...:.......||:..||....:.:    :.
Mouse    31 REKLPPIVTAGAAAGLDRGSKGQISTFSSFVSTVTQKKEAAENRSSPTHLALPNIRNVRDLPPIC 95

  Fly   376 LVIRQIFSGGDQSIVTTTLFVD-KVPP-------------EDFRNYNPKSQILTLTAEVTKQCAQ 426
            |.:||     .|.:....|..: ||||             :||.....|       ||.|.....
Mouse    96 LDVRQ-----KQRMSVEALPSEVKVPPLPEPSLPSQPKTVKDFEEDLEK-------AEATGNWKT 148

  Fly   427 CKQGLQSDMDLLSSIELIFRSQACWNGSFLLDHDRHFGCSVRNHGLDLKAAQLAFDNLRAVENES 491
            ......:..|..:.:...|:..|  ..||         .::.:.||:.......||.|.     :
Mouse   149 VHAFYITAFDSFTELNTAFKKDA--TASF---------NTIEDSGLNANLVNAVFDALL-----N 197

  Fly   492 IRQVIWDNITKELVGSLV---CSPADVESMRLYLLLPLYHEFVNSKHYKSLQVPFANAIFKLA-- 551
            ..|.|..::.|.::.||:   ..|...:.:|.|.:|....:|    :..|..|.:|:.:.::|
Mouse   198 TPQDIQKSVLKGIINSLLQEWKGPRTKDDLRAYFILLQNPQF----NITSTYVIYAHLLRQIATL 258

  Fly   552 -ENPRKVLNKWLAQTPAEYFEHLVQNFLHVVIHIISFKMGLAAASPSAERRQQLLPYNTELEIIL 615
             |.....|..||.:...:.|:.||:..|..|      .:.|..|.|  |....|......:....
Mouse   259 VEADHHFLVHWLKKLSQKKFKQLVERLLQFV------SLRLFPAKP--EEFPPLTKCTWWIPSAA 315

  Fly   616 KLMKTLCQINNERHDRL-NYQIFYWPDLSDYADVQQEYVKW-IMADTARDFNICNYSFIFDQSAK 678
            |::..|...||..|..| .|..||...| |:.|:.:||..| ...::...|:.|.|.|:...:||
Mouse   316 KVLALLNTANNLVHPPLVPYTDFYNSTL-DHIDLMEEYHTWQSFGNSHSRFSFCQYPFVISIAAK 379

  Fly   679 TALLQADQALQMHSAMANAATMAFSFFNYGMPISQFIVLN--VTRENLVQDSLRELQHYSQSDLK 741
            ..::|.|...||.|....:.....|  ....|....:.||  |.|.:||.|||.||.. .::|||
Mouse   380 KIIIQRDSEQQMISIARQSLVDKVS--RRQRPDMNMLFLNMKVRRTHLVSDSLDELTR-KRADLK 441

  Fly   742 KPLKIKFHGEEAEDAGGVRKEFFMLLLKDLLDPKYGMFKEYEQSRLLWFADLTFETENMYFLIGV 806
            |.||:.|.||...|.||:.||:|:||::.:..|.||||..::.|...||:....:..:.:.|:|:
Mouse   442 KKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMFTYHKDSHCHWFSSFKCDNYSEFRLVGI 506

  Fly   807 LCGLAIYNFTIINLPFPLALFKKLLGKP--------------VDLSDLRQLSPPEANSMQSLLDY 857
            |.|||:||...:::.||...:||||..|              |.:.||.|:.|..|:.::.||.|
Mouse   507 LMGLAVYNSITLDIRFPPCCYKKLLSPPVVPSDQSTPVGICSVTIDDLCQVMPELAHGLKELLSY 571

  Fly   858 QGDDFKEVFDLTFEISRDVFGEAETKCLKPNGNEIAVTLENRQEFVDLYVDFVFNKSVELHYNAF 922
            :| :.:|.|..||::.::.||..::..|||.|::|.||.:||:|:|.||.||:.|||:...:.||
Mouse   572 EG-NVEEDFYSTFQVFQEEFGVIKSYNLKPGGDKIPVTNQNRREYVQLYTDFLLNKSIYKQFAAF 635

  Fly   923 HKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQALQDNCEYREGYTSVDDTIKWFWEVIHDMSE 987
            :.||..||:...:.:.:|||:..:|.|:.:.|..|||.:.:| :||...|.||::||:|:.....
Mouse   636 YCGFHSVCASNALMLLRPEEVEILVCGSPELDMHALQRSTQY-DGYAKTDLTIRYFWDVVLGFPL 699

  Fly   988 AEKKSFLLFLTGSDRIPIQGMKALKLTIQPT-PDERFLPVAHTCFNLLDLPRYKTKERLKYKLLQ 1051
            ..:|..|.|.|||||:|:.||..|...|... ....:|||||||||.|.||.||:|:.||.||:.
Mouse   700 ELQKKLLHFTTGSDRVPVGGMADLNFKISKNETSTNWLPVAHTCFNQLCLPPYKSKKDLKQKLII 764

  Fly  1052 AIQQTQGFSL 1061
            .|..::||.|
Mouse   765 GISNSEGFGL 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	ATS1	7..352	CDD:444065	9/36 (25%)
		RCC1	327..390	CDD:395335	15/68 (22%)
		HECTc	715..1060	CDD:238033	143/361 (40%)
Hectd2	NP_001156943.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..51		4/19 (21%)
		HECTc	416..773	CDD:238033	143/359 (40%)