DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Herc4 and Ube3a

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_001380595.1	Gene:	Ube3a / 22215	MGIID:	105098	Length:	870	Species:	Mus musculus

Alignment Length:	775	Identity:	229/775 - (29%)
Similarity:	386/775 - (49%)	Gaps:	121/775 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   368 QSND-SQVSLVIRQIFSGGDQSIVTTTLFVDKVPPEDFRNYNPKSQILTLTAEVTKQCAQCKQGL 431
            :|.| |.:..||.:|||.. :::|.:...|.:...|:.::...|.:.   ..|..|:.|.|....
Mouse   137 ESEDYSPLIRVIGRIFSSA-EALVLSFRKVKQHTKEELKSLQEKDED---KDEDEKEKAACSAAA 197

  Fly   432 QSDMDLLSSIELIFRSQACWNGSFLLDHDRHFGCSVRNHG-----LDLKAAQLAFDNLRAVENES 491
            ..:....||..:...||...|              |:..|     :|:.|.:..:.:|.|  ||.
Mouse   198 MEEDSEASSSRMGDSSQGDNN--------------VQKLGPDDVTVDIDAIRRVYSSLLA--NEK 246

  Fly   492 IRQVIWDNITKELVGSLVCS-------PADVESMRLYLLLPLYHEFVNSKHYKSLQVP-FANAIF 548
            : :..:.|....|..::.|.       ..|...:.|:::: :.:..::|..|..:.:| |..|:.
Mouse   247 L-ETAFLNALVYLSPNVECDLTYHNVYTRDPNYLNLFIIV-MENSNLHSPEYLEMALPLFCKAMC 309

  Fly   549 KL-AENPRKVLNKWLAQTPAEYFEHLVQNFLHVVIH-IISFKM----------GLAAAS------ 595
            || .|...|::..| ::..|:....:::.|..::.: :||.:.          .:.|||
Mouse   310 KLPLEAQGKLIRLW-SKYSADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMV 373

  Fly   596 ---------------------PSAERR----QQLL-------------PYNTELEIILKLMKTL- 621
                                 |..|..    |:||             |..|||.:     |||
Mouse   374 YYANVVGGDVDTNHNEEDDEEPIPESSELTLQELLGDERRNKKGPRVDPLETELGV-----KTLD 433

  Fly   622 CQINNERHDRLNYQIFYWPDLSDYADVQQEYVKWIMADTARDFNICNYSFIFDQSAKTALLQADQ 686
            |     |...::::.|....|:|..::.::|. :...:|...|:.....||.:...|...|..|.
Mouse   434 C-----RKPLISFEEFINEPLNDVLEMDKDYT-FFKVETENKFSFMTCPFILNAVTKNLGLYYDN 492

  Fly   687 ALQMHSAMANAATMAFSFFNYGMPISQFIVLNVTRENLVQDSLRELQHYSQ---SDLKKPLKIKF 748
            .::|:|  ....|:.:|... |..::.::.|.|.|::::.|:|..|:..:.   :||||.|.::|
Mouse   493 RIRMYS--ERRITVLYSLVQ-GQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEF 554

  Fly   749 HGEEAEDAGGVRKEFFMLLLKDLLDPKYGMFKEYEQSRLLWFADLTFETENMYFLIGVLCGLAIY 813
            .||:..|.|||.||||.|:::::.:|..|||...|.::|.||...:||||..:.|||::.|||||
Mouse   555 EGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDEATKLFWFNPSSFETEGQFTLIGIVLGLAIY 619

  Fly   814 NFTIINLPFPLALFKKLLGKPVDLSDLRQLSPPEANSMQSLLDYQG---DDFKEVFDLTFEISR- 874
            |..|:::.||:.:::||:||.....||....|....|::.||:|:|   ||..    :||:||:
Mouse   620 NNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGSVEDDMM----ITFQISQT 680

  Fly   875 DVFGEAETKCLKPNGNEIAVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVI-HIF 938
            |:||......||.||::|.:|.|||:|||:||.|::.|||||..:.||.:||..|.:...: ::|
Mouse   681 DLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLF 745

  Fly   939 QPEELMAVVVGNEDYDWQALQDNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRI 1003
            :|||:..::.|:.:.|:|||::..||..|||.....|:.|||::|..::.:|:.||.|.||:||.
Mouse   746 RPEEIELLICGSRNLDFQALEETTEYDGGYTRESVVIREFWEIVHSFTDEQKRLFLQFTTGTDRA 810

  Fly  1004 PIQGMKALKLTIQPT-PDERFLPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGFSLV 1062
            |:.|:..||:.|... ||...||.:|||||:|.||.|.:||:||.:||:||...:||.::
Mouse   811 PVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGML 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826
		RCC1	59..110	CDD:278826
		RCC1	114..163	CDD:278826
		RCC1	167..218	CDD:278826
		RCC1	221..270	CDD:278826
		RCC1	273..322	CDD:278826
		RCC1_2	309..339	CDD:290274
		RCC1	327..390	CDD:278826	8/22 (36%)
		HECTc	715..1060	CDD:238033	147/353 (42%)
		HECTc	739..1059	CDD:214523	140/325 (43%)
Ube3a	NP_001380595.1	AZUL	27..81	CDD:406862
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..223		12/68 (18%)
		HECTc	518..868	CDD:238033	147/353 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276447at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820