Protein Alignment Herc4 and Ube3a

DIOPT Version :10

• Sequence 1: NP_001261249.1
• Gene: Herc4 / 38151
• FlyBaseID: FBgn0035207
• Length: 1062
• Species: Drosophila melanogaster
• Sequence 2: NP_035798.2
• Gene: Ube3a / 22215
• MGIID: 105098
• Length: 870
• Species: Mus musculus
• Alignment Length: 775
• Identity: 229/775 - (29%)
• Similarity: 386/775 - (49%)
• Gaps: 121/775 - (15%)

  Fly   368 QSND-SQVSLVIRQIFSGGDQSIVTTTLFVDKVPPEDFRNYNPKSQILTLTAEVTKQCAQCKQGL 431
            :|.| |.:..||.:|||.. :::|.:...|.:...|:.::...|.:.   ..|..|:.|.|....
Mouse   137 ESEDYSPLIRVIGRIFSSA-EALVLSFRKVKQHTKEELKSLQEKDED---KDEDEKEKAACSAAA 197

  Fly   432 QSDMDLLSSIELIFRSQACWNGSFLLDHDRHFGCSVRNHG-----LDLKAAQLAFDNLRAVENES 491
            ..:....||..:...||...|              |:..|     :|:.|.:..:.:|.|  ||.
Mouse   198 MEEDSEASSSRMGDSSQGDNN--------------VQKLGPDDVTVDIDAIRRVYSSLLA--NEK 246

  Fly   492 IRQVIWDNITKELVGSLVCS-------PADVESMRLYLLLPLYHEFVNSKHYKSLQVP-FANAIF 548
            : :..:.|....|..::.|.       ..|...:.|:::: :.:..::|..|..:.:| |..|:.
Mouse   247 L-ETAFLNALVYLSPNVECDLTYHNVYTRDPNYLNLFIIV-MENSNLHSPEYLEMALPLFCKAMC 309

  Fly   549 KL-AENPRKVLNKWLAQTPAEYFEHLVQNFLHVVIH-IISFKM----------GLAAAS------ 595
            || .|...|::..| ::..|:....:::.|..::.: :||.:.          .:.|||
Mouse   310 KLPLEAQGKLIRLW-SKYSADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMV 373

  Fly   596 ---------------------PSAERR----QQLL-------------PYNTELEIILKLMKTL- 621
                                 |..|..    |:||             |..|||.:     |||
Mouse   374 YYANVVGGDVDTNHNEEDDEEPIPESSELTLQELLGDERRNKKGPRVDPLETELGV-----KTLD 433

  Fly   622 CQINNERHDRLNYQIFYWPDLSDYADVQQEYVKWIMADTARDFNICNYSFIFDQSAKTALLQADQ 686
            |     |...::::.|....|:|..::.::|. :...:|...|:.....||.:...|...|..|.
Mouse   434 C-----RKPLISFEEFINEPLNDVLEMDKDYT-FFKVETENKFSFMTCPFILNAVTKNLGLYYDN 492

  Fly   687 ALQMHSAMANAATMAFSFFNYGMPISQFIVLNVTRENLVQDSLRELQHYSQ---SDLKKPLKIKF 748
            .::|:|  ....|:.:|... |..::.::.|.|.|::::.|:|..|:..:.   :||||.|.::|
Mouse   493 RIRMYS--ERRITVLYSLVQ-GQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEF 554

  Fly   749 HGEEAEDAGGVRKEFFMLLLKDLLDPKYGMFKEYEQSRLLWFADLTFETENMYFLIGVLCGLAIY 813
            .||:..|.|||.||||.|:::::.:|..|||...|.::|.||...:||||..:.|||::.|||||
Mouse   555 EGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDEATKLFWFNPSSFETEGQFTLIGIVLGLAIY 619

  Fly   814 NFTIINLPFPLALFKKLLGKPVDLSDLRQLSPPEANSMQSLLDYQG---DDFKEVFDLTFEISR- 874
            |..|:::.||:.:::||:||.....||....|....|::.||:|:|   ||..    :||:||:
Mouse   620 NNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGSVEDDMM----ITFQISQT 680

  Fly   875 DVFGEAETKCLKPNGNEIAVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVI-HIF 938
            |:||......||.||::|.:|.|||:|||:||.|::.|||||..:.||.:||..|.:...: ::|
Mouse   681 DLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLF 745

  Fly   939 QPEELMAVVVGNEDYDWQALQDNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRI 1003
            :|||:..::.|:.:.|:|||::..||..|||.....|:.|||::|..::.:|:.||.|.||:||.
Mouse   746 RPEEIELLICGSRNLDFQALEETTEYDGGYTRESVVIREFWEIVHSFTDEQKRLFLQFTTGTDRA 810

  Fly  1004 PIQGMKALKLTIQPT-PDERFLPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGFSLV 1062
            |:.|:..||:.|... ||...||.:|||||:|.||.|.:||:||.:||:||...:||.::
Mouse   811 PVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGML 870

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	ATS1	7..352	CDD:444065
		RCC1	327..390	CDD:395335	8/22 (36%)
		HECTc	715..1060	CDD:238033	147/353 (42%)
Ube3a	NP_035798.2	AZUL	27..81	CDD:465173
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	171..223		12/68 (18%)
		HECTc	518..868	CDD:238033	147/353 (42%)