DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Herc4 and Rpgr

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_001171421.1	Gene:	Rpgr / 19893	MGIID:	1344037	Length:	1039	Species:	Mus musculus

Alignment Length:	1111	Identity:	259/1111 - (23%)
Similarity:	419/1111 - (37%)	Gaps:	294/1111 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASGKELYCWGSTSHGQLGLGGIEDEQILTPSQIPWTPDTAVQQVACGHRHTLFLTATGKVYACG 65
            :....:||.:||.:.||||||  ....|:.|:.|.......|:..|||..|||..|.||.|||.|
Mouse    88 VTGNNKLYMFGSNNWGQLGLG--SKAAIIKPTCIKALKPEKVKLAACGRNHTLVSTDTGGVYAAG 150

  Fly    66 SNDYSQLGHDLPTKRPRMSPFLLIPELQDYVIIQICCGSRHSLALSDWGQVLSWGDNDCGQLGHA 130
            .|:..|||......|......:......  .|.|:..|:..|.||::.|::..||||..||:| .
Mouse   151 GNNEGQLGLGDTDDRDTFHQIVFFTPAD--TIKQLSAGANTSAALTEDGKLFMWGDNSEGQIG-L 212

  Fly   131 TDKEIVQLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGSNIYGQLGVNSPNDL--THCNY 193
            .||..|.:|..|  .|.|.:..|:||..||..:|..||||::|....|:||:  ||:|  .| ..
Mouse   213 EDKSNVCIPHEV--TVGKPISWISCGYYHSAFVTMDGELYTFGEPENGKLGL--PNELLMNH-RS 272

  Fly   194 PLRLTTLLGIP--LAAIACGGNHSFLISKSGAVFGWGRNNCGQLGLND---ETNRSYPTQLKTLR 253
            |.|   :||||  :..:||||.|:.::::. .|:.:|....|||||..   ||  |.|..::.::
Mouse   273 PQR---VLGIPERVIQVACGGGHTVVLTEK-VVYAFGLGQFGQLGLGTFLFET--SEPKIIERIK 331

  Fly   254 TLGVRFVACGDEFSVFLTNEGGVFTCGAGAYGQLGHGFS--SNEMLPRMVMELMGSTITQVACGN 316
            ...:..::||:..:..:|..|.::|.|.|.:|:||.|..  :|:..|.:....:...:..:|||.
Mouse   332 DQKICHISCGENHTALMTELGLLYTFGDGRHGKLGLGMENFTNQFFPTLCSNFLRFAVQLIACGG 396

  Fly   317 RHTLALVPSRGRVYAFGLGSSGQLGTRSTKSLMLPQVVIGPW----VSP------SGSALLQSND 371
            .|.|.....|          .|.:.....:.:..|.:..|.:    :||      |.||.|:..:
Mouse   397 CHMLVFATPR----------LGTIDEPKFEDVYEPYISTGSFSINDLSPRSSLNRSLSARLRRRE 451

  Fly   372 SQ-----VSLVIRQIFSGG------DQSIVTTTLFVDKVPP--EDFRNYNPKSQILTLTAEVTKQ 423
            .:     .|:|       |      ..|..|:..|....||  ....||..||.
Mouse   452 RERPPCSASMV-------GTLPPLEGTSASTSAYFYPSSPPFHLSVNNYPEKSP----------- 498

  Fly   424 CAQCKQGLQSDM--DLLSSIELIFRSQACWNGSFLLDHD----RHFGCSVRNHGLDLKAAQLAFD 482
             ::..:.|.||.  |.::.......|.|..:.:|...:|    .|...:..|..|      |.|.
Mouse   499 -SESMEPLDSDYFEDKMNKDTETENSSAVDSENFGETNDILNMTHMMTTSSNEKL------LDFS 556

  Fly   483 NLRAVENESIRQVIWDNITKELVGSLVCSPADVESMRLYLLLPLYHEFVNSKHYKSLQVPFANAI 547
            .::..:|:       |...| ::.|..|:                 |..:|..|:.:.
Mouse   557 PIQKQQNQ-------DTFEK-VMESTPCT-----------------ENEDSYEYEEMS------- 589

  Fly   548 FKLAENPRKVLNKWLAQ-----TPAEYFEHL----VQNFLHVV--IHIISFKMGLAAASPSAERR 601
             |:.|  ..|..::||:     .|||..|..    |.|.|..|  ..:.:...||.:.....|..
Mouse   590 -KIKE--VTVYKQYLAKGIYMIRPAEILEAFSDEEVGNGLDQVEEPRVFTDGKGLQSKQVGKESD 651

  Fly   602 QQLL-PYNTELEIILKLMKTLCQINNERHDRLNYQIFYWPDLSDYA-DVQQEYVKWIMADTARDF 664
            :::: ...||:..:..:.|......|.:.|.|      :.||.|.. :.:.|..|    |.|.:.
Mouse   652 EEIVSEKKTEVMEVADVKKIRESEENSKSDSL------FDDLPDKTMNSESEDNK----DIAEER 706

  Fly   665 NICNYSFIFDQSAKTALLQADQALQMHSAMANAATMAFSFFNYGMPISQFIVLNVTRENLVQDSL 729
            .....:..||  ::|.|::.                                         .||.
Mouse   707 RSSEQNMTFD--SETELVEE-----------------------------------------PDSY 728

  Fly   730 RELQHYSQSD----LKKPLKIKFHGEEAEDAGGVRKEFFMLLLKDLLDPKYGMFKEYEQSRLLWF 790
            .|.:.:|:.|    |::|..:::..||.::             ||..|.     .|.|...|.:.
Mouse   729 MECERHSEQDSAEELEQPKLVEYSSEEKDE-------------KDEKDD-----DEVETENLWYD 775

  Fly   791 ADLT-FETENMYFLIGVLCGLAIYNFTIINLPFPLALFKKLLGKPVDLSDL--RQLSPPEA---- 848
            .:.| .||||            ::..|        ..|.|...|...||.:  .|..|.::
Mouse   776 RNCTEQETEN------------VFRAT--------RFFPKFDLKHDHLSGIPEEQEGPEDSEGNV 820

  Fly   849 ------NSMQSLLDYQGDDFKEVFDLTFEISRDVFGEAE----TKCLKPNGNEI--AVTLENRQE 901
                  .:.:..|:::||. ||.   ..|...||..|.|    ::.:||...|:  .:::.|.::
Mouse   821 VVEQVVQAQKENLEFEGDR-KEA---KAEAPSDVITEKEAPQLSETVKPEEGEMDEEISILNVED 881

  Fly   902 FVDLYVDFVFNKSVELHYNAFHKGFMKVCSG-RVIHIFQPEELMAVVVGNEDYD---WQALQDNC 962
            .|:       .:..|.......:|.:....| ..|.|  .:|.:..|:..||..   .:||::..
Mouse   882 TVE-------EERKEGEKEIVEEGSIPETEGSETIDI--TDEKLDEVLKEEDSASLLQRALREYN 937

  Fly   963 EYREG--YTSV-----------DDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKALKLT 1014
            |..:|  |..|           |.|.|       |:.:|:|.||.      :|:.:.|.|.::.|
Mouse   938 ENPKGHMYDRVKSSSSEILGGNDPTSK-------DIKKAKKISFF------NRMSLTGQKLMQNT 989

  Fly  1015 IQPTPD 1020
            ..|.|:
Mouse   990 NDPLPE 995

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826	20/48 (42%)
		RCC1	59..110	CDD:278826	14/50 (28%)
		RCC1	114..163	CDD:278826	20/48 (42%)
		RCC1	167..218	CDD:278826	23/54 (43%)
		RCC1	221..270	CDD:278826	13/51 (25%)
		RCC1	273..322	CDD:278826	15/50 (30%)
		RCC1_2	309..339	CDD:290274	6/29 (21%)
		RCC1	327..390	CDD:278826	13/83 (16%)
		HECTc	715..1060	CDD:238033	72/346 (21%)
		HECTc	739..1059	CDD:214523	68/322 (21%)
Rpgr	NP_001171421.1	RCC1_2	78..104	CDD:290274	4/15 (27%)
		RCC1	93..139	CDD:278826	19/47 (40%)
		RCC1	144..193	CDD:278826	14/50 (28%)
		RCC1_2	180..209	CDD:290274	11/28 (39%)
		RCC1	196..243	CDD:278826	20/49 (41%)
		RCC1	246..296	CDD:278826	23/55 (42%)
		RCC1	301..348	CDD:278826	13/48 (27%)
		RCC1	352..398	CDD:278826	13/45 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45622
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020