DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Herc4 and ran-3

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_495753.1	Gene:	ran-3 / 174332	WormBaseID:	WBGene00004304	Length:	569	Species:	Caenorhabditis elegans

Alignment Length:	345	Identity:	86/345 - (24%)
Similarity:	134/345 - (38%)	Gaps:	55/345 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 QVACGHRHTLFLTATGKVYACGSNDYSQLGHDLPTKRPRMSPFLLIPELQDY----VIIQICCGS 104
            |...|..|:..||:.|:||.||.|:...:..:...|......|..:...:|.    .|:.:..|:
Worm   189 QAVAGGVHSAVLTSEGEVYMCGINEKGTVPAEGVEKEGSTDEFAKVKFEEDIEKEGKIVMLAAGA 253

  Fly   105 RHSLALSDWGQVLSWGD--NDCGQLG-HATDKEIVQLPKVVRQLVTKTVVQIACGNNHSLALTSC 166
            ..:.||:|.|.|::||:  |..|.:. |....::.:.|.|:.....:.:|:||.|.||.:.|...
Worm   254 SFTAALTDQGSVIAWGNLRNSNGNVDVHPLLHKMQEAPVVIVHQAKRKIVKIAAGENHLVMLDEK 318

  Fly   167 GELYSWGSNIYGQLGVNSPNDLTHCNY-----------PLRLT---TLLGIPLAAIACGGNHSFL 217
            |.|.::|....||||.:|........|           |||..   ....:....:...|..:.:
Worm   319 GCLLTFGDGEMGQLGRSSRTKTIRSKYMCDESGDHLLVPLRFKHKGKFFDVVAKNVFASGFWTIV 383

  Fly   218 ISKSGAVFGWGRNNCGQLGL-------------NDETNRSYPTQLKTL---RTL----GVRFVAC 262
            ..:.|..:.:|.||..|||:             |.|.....|.:....   ||.    ||:.|
Worm   384 HGEDGKYYAFGLNNYAQLGIKVDEADVGQDGQDNRELRVFLPAEAPAFGAERTFVNIEGVQHV-- 446

  Fly   263 GDEFSVFLTNEGGVFTCGAGAYGQLGHG-----FSSNEMLPRMVMEL-MGSTITQVACGNRHTLA 321
                 |.|.::|.||..|......||.|     ......|...:.|: ..|.|..|:.....::|
Worm   447 -----VILGSDGKVFAMGKNTDNALGLGNWTGKDDQQHWLYDTIQEIEFDSKIVGVSAKLATSIA 506

  Fly   322 LVPSRGRVYAFGLGSSGQLG 341
            . ...|..||:|..::||||
Worm   507 W-SEDGTAYAWGFDTTGQLG 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826	3/10 (30%)
		RCC1	59..110	CDD:278826	11/54 (20%)
		RCC1	114..163	CDD:278826	15/51 (29%)
		RCC1	167..218	CDD:278826	13/64 (20%)
		RCC1	221..270	CDD:278826	16/68 (24%)
		RCC1	273..322	CDD:278826	12/54 (22%)
		RCC1_2	309..339	CDD:290274	7/29 (24%)
		RCC1	327..390	CDD:278826	8/15 (53%)
		HECTc	715..1060	CDD:238033
		HECTc	739..1059	CDD:214523
ran-3	NP_495753.1	ATS1	163..569	CDD:227511	86/345 (25%)
		RCC1_2	189..215	CDD:290274	11/25 (44%)
		RCC1_2	246..276	CDD:290274	10/29 (34%)
		RCC1_2	302..331	CDD:290274	10/28 (36%)
		RCC1	510..565	CDD:278826	8/16 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920