Protein Alignment Herc4 and herc-1

DIOPT Version :9

• Sequence 1: NP_001261249.1
• Gene: Herc4 / 38151
• FlyBaseID: FBgn0035207
• Length: 1062
• Species: Drosophila melanogaster
• Sequence 2: NP_490834.1
• Gene: herc-1 / 171700
• WormBaseID: WBGene00021685
• Length: 1019
• Species: Caenorhabditis elegans
• Alignment Length: 1121
• Identity: 377/1121 - (33%)
• Similarity: 560/1121 - (49%)
• Gaps: 171/1121 - (15%)

  Fly     6 ELYCWGSTSHGQLGLGGIEDEQILTPSQIPWTPD----TAVQQVACGHRHTLFLTATGKVYACGS 66
            ||...|.|..||||: .:.:..|..|.:|...|:    |||..|.||.:||:|||..||:::.||
 Worm     4 ELLGCGHTGEGQLGV-RLSESTIQVPERIIGAPNDMDGTAVTSVTCGEQHTVFLTKDGKMWSVGS 67

  Fly    67 NDYSQLGHDLPTKRPRMSPFLLIPE--LQDYVIIQICCGSRHSLALSDWGQVLSWGDNDCGQLGH 129
            |...|||....|:    ..|.:.|.  .....||||..|..|:::::|.|:|.:||.|:.||||.
 Worm    68 NMDGQLGRGSRTE----GSFSIYPVSWTSSAKIIQISAGRSHTVSVTDDGRVFAWGSNEHGQLGM 128

  Fly   130 ATDKEIVQLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGSNIYGQLGVNSPNDLTHC-NY 193
            .:.......|:.|:::  ..:||:|.|:||.:||...|.::.||....|:           | :.
 Worm   129 ESKFTWQGTPRRVQEI--NDIVQVASGSNHCIALDEGGRVFVWGEQADGR-----------CIHR 180

  Fly   194 PLRLTTLLGIPLAAIACGGNHSFLISKSGAVFGWGRNNCGQLGLNDETNRSYPTQLKTLRTLGVR 258
            |..:..|.|:|:..:..|..|...:|.|||||.||:||.|:||::|...::....:..:..|||.
 Worm   181 PEPVEQLSGVPIVRVLAGARHCLALSASGAVFTWGQNNSGELGIDDLRPQTSVQHVHQMDGLGVV 245

  Fly   259 FVACGDEFSVFLTNEGGVFTCGAGAYGQLGHGFSSNEML-PRMVMELMGSTITQVACGNRHTLAL 322
            ..||||..:|.||:.|..|:.|:.|.||.|.|....:.. |..|.:|:||.:|::|.|..||:|:
 Worm   246 EAACGDNHTVLLTHCGRTFSFGSDALGQCGFGKKVEKRTNPTAVSDLIGSHVTRIAAGACHTIAI 310

  Fly   323 VPSRGRVYAFGLGSSGQLGTRSTKSLMLPQVVIGPWVSPSGSALLQSNDSQVSLV--IRQIFSGG 385
              .:|..|.|||.||||||                    :|..:.||...:...:  :..:|:|.
 Worm   311 --CKGAPYPFGLNSSGQLG--------------------NGKIMTQSTPRKTDELDHVTGVFAGY 353

  Fly   386 DQSIVTTTLFV---------DKVPPEDFRNYNPKSQILTLTAEVTKQCAQCKQGLQSD-MDLLSS 440
            .|     |.||         :.|.|.     .|....:.|..|..|:...     :.| ::::|.
 Worm   354 HQ-----TFFVRSSGTIEQNEIVGPS-----CPMQYPIKLDHESLKKLLD-----EGDALEVMSL 403

  Fly   441 IELIFRSQACWNGSFLLDHDRHFG---CSVRNHGLDLKAAQLAF-----------------DNLR 485
            ||.:|.|.|..|.|||...:|.:.   |..|:||:|:.....||                 |:|:
 Worm   404 IESVFSSLASMNMSFLYKDERRYNVGFCFERSHGIDMDQVMEAFMLFDEYPMKRQYMELIVDSLK 468

  Fly   486 AVENESIRQVIWDNITKELVGSLVCSPADVESMRLYLL---LPLYHEFVNSKHYKSLQVPFANAI 547
            ....|      |   ::.|.|        :|.:|:.|:   ||::.|.||.:..|::..||.:|:
 Worm   469 IAFQE------W---SENLKG--------IECLRVLLMLPWLPIFTENVNVQTIKNVHTPFVDAM 516

  Fly   548 FKLAENPRKVLNKWLAQTPAEYFEHLVQNFLHVVIHIISFKMGLAAASPSAERRQQLLPYNTELE 612
            ..:..:.|..|.||..|....:|..:|..|...:..::..|.|               |.:....
 Worm   517 CLITGDLRAALEKWWTQLSTRHFRRMVTVFKTAIKAMLKAKKG---------------PRDCHKF 566

  Fly   613 IILKLMKTLCQINNERHDRLNYQIFYWPDLSDYADVQQEYVKWIMADTARDFN------ICNYSF 671
            |:  :|:.|..||...| .:..:.||..:|:...|::.|||   :..|.:|.|      ..::.|
 Worm   567 IL--IMQKLSLINKTYH-IIPLETFYIDELNTSVDLKLEYV---LELTRQDPNKTELDYWTHFPF 625

  Fly   672 IFDQSAKTALLQAD----QALQMHSAMANAA--TMAFSFFNYGMPISQFIVLNVTRENLVQDSLR 730
            :.:..||..|:..:    |.|:..|::.|.|  |:.|.     :|   .:.|.|.||.:|.|::.
 Worm   626 LLNGVAKGELIFVEAWLMQTLRRQSSLFNTAHGTIIFE-----LP---HLELTVRREFIVSDTMN 682

  Fly   731 ELQHYSQSDLKKPLKIKFHGEEAEDAGGVRKEFFMLLLKDLLDPKYGMFKEYEQSRLLWFADLTF 795
            ::...|:|||:||||:...||:|:||||||||||:|:::.:|...||||.|.|:|.|:||:.|..
 Worm   683 QMAGLSESDLQKPLKVNIAGEDADDAGGVRKEFFILVMRKILQSDYGMFSEDEESHLVWFSGLPS 747

  Fly   796 E--TENMYFLIGVLCGLAIYNFTIINLPFPLALFKKLLGKPVDLSDLRQLSPPEANSMQSLLDYQ 858
            |  ....:..:|.|.||:|||.:|:..||||||:|.||..|.||.||.:|||.|...::.||.|:
 Worm   748 EFCDREQFHQLGRLVGLSIYNHSIVPFPFPLALYKYLLDTPPDLEDLCELSPSEGKGLKMLLSYE 812

  Fly   859 GDDFKEVFDLTFEISRDVFGEAETKCLKPNGNEIAVTLENRQEFVDLYVDFVFNKSVELHYNA-- 921
            .||.::||.|.|.||.::.||..|..|...|.|..||..||.|:|.|||    :..:||.||.
 Worm   813 EDDVEDVFGLNFCISFNILGETHTTELLSGGTEKPVTNANRDEYVRLYV----HHRLELGYNGEI 873

  Fly   922 ------FHKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQALQDNCEYREGYTSVDDTIKWFWE 980
                  |.|||.:....|.:..|||.||..::||||:|||...:|...||..|:|...||:.||:
 Worm   874 AQQALLFRKGFSESLHSRTLRFFQPCELKEMIVGNENYDWNEFRDILMYRGEYSSSHPTIQAFWK 938

  Fly   981 VIHDMSEAEKKSFLLFLTGSDRIPIQGMKALKLTIQPTPDERFLPVAHTCFNLLDLPRYKTKERL 1045
            ....:::.|::.||.|||||.|||:.|.:.|...|||:..|. ||||||||||||||.......|
 Worm   939 AFFALTDDERRKFLQFLTGSTRIPVSGWEELHAAIQPSAPES-LPVAHTCFNLLDLPNIADDVEL 1002

  Fly  1046 KYKLLQAIQQTQGFSL 1061
            ..:|..:|:.|:||:|
 Worm  1003 LRRLRISIEHTEGFTL 1018

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826	20/52 (38%)
		RCC1	59..110	CDD:278826	17/52 (33%)
		RCC1	114..163	CDD:278826	17/48 (35%)
		RCC1	167..218	CDD:278826	11/51 (22%)
		RCC1	221..270	CDD:278826	21/48 (44%)
		RCC1	273..322	CDD:278826	18/49 (37%)
		RCC1_2	309..339	CDD:290274	13/29 (45%)
		RCC1	327..390	CDD:278826	17/64 (27%)
		HECTc	715..1060	CDD:238033	159/354 (45%)
		HECTc	739..1059	CDD:214523	150/329 (46%)
herc-1	NP_490834.1	ATS1	2..359	CDD:227511	132/399 (33%)
		HECTc	667..1016	CDD:238033	158/353 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162180
Domainoid	1	1.000	239	1.000	Domainoid score	I1271
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	514	1.000	Inparanoid score	I701
Isobase	1	0.950	-	0	Normalized mean entropy	S2533
OMA	1	1.010	-	-		QHG57432
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	1	1.000	-	-		FOG0001110
OrthoInspector	1	1.000	-	-		oto20793
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R774
SonicParanoid	1	1.000	-	-		X678
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.790