DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Herc4 and wwp-1

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_740775.1	Gene:	wwp-1 / 171647	WormBaseID:	WBGene00007009	Length:	794	Species:	Caenorhabditis elegans

Alignment Length:	418	Identity:	128/418 - (30%)
Similarity:	201/418 - (48%)	Gaps:	38/418 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   671 FIFDQSAKTALLQADQ-----------ALQMHSAMANAATMAFSFFNY---GMPISQFIVLNVTR 721
            |..|..:||......:           .:||  ||..:.....:.|.|   ...:...:.:.|:|
Worm   383 FFIDHQSKTTTYNDPRTGKPVGPLGVVGVQM--AMEKSFRWKIAQFRYLCLSNSVPNHVKITVSR 445

  Fly   722 ENLVQDSLRELQHYSQSDLKKPLKIKFHGEEAEDAGGVRKEFFMLLLKDLLDPKYGMF-----KE 781
            .|:.:||.:|:...:..||::.|.|:|.|||..|.|||.:|:|.||..::|:|.|.:|     ..
Worm   446 NNVFEDSFQEIMRKNAVDLRRRLYIQFRGEEGLDYGGVAREWFFLLSHEVLNPMYCLFMYAGNNN 510

  Fly   782 YEQSRLLWFADLTFETEN--MYF-LIGVLCGLAIYNFTIINLPFPLALFKKLLGKPVDLSDLRQL 843
            |.    |.....:|...:  .|| .||....:|:::...|...|.:..:||:|.|.:.|.|:.|:
Worm   511 YS----LQINPASFVNPDHLKYFEYIGRFIAMALFHGKFIYSGFTMPFYKKMLNKKIVLKDIEQV 571

  Fly   844 SPPEANSMQSLLDYQGDDFKEVFDLTFEISRDVFGEAETKCLKPNGNEIAVTLENRQEFVDLYVD 908
            .....||:..:.|...|:..  .:|.|....::.||.:|..||..|.|||||.||:.|:::|.|:
Worm   572 DSEIYNSLMWIKDNNIDECD--MELYFVADYELLGELKTYELKEGGTEIAVTEENKLEYIELLVE 634

  Fly   909 FVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQALQDNCEYREGYTSVDD 973
            :.||:.||....||..||..|.....:..|...||..::.|.:|.|....|.|..||. |.....
Worm   635 WRFNRGVEQQTKAFFTGFNSVFPLEWMQYFDERELELLLCGMQDVDVDDWQRNTVYRH-YAPQSK 698

  Fly   974 TIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKALK-------LTIQPTPDERFLPVAHTCF 1031
            .:.|||:.:..:.:.::...|.|:||:.|:|:.|...|.       ..|:....|.:||.:||||
Worm   699 QVTWFWQWVRSLDQEKRARLLQFVTGTCRVPVGGFSELMGSTGPQLFCIERVGKENWLPRSHTCF 763

  Fly  1032 NLLDLPRYKTKERLKYKLLQAIQQTQGF 1059
            |.||||.|::.::|..||..||:.|:||
Worm   764 NRLDLPPYRSYDQLVEKLSMAIEMTEGF 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826
		RCC1	59..110	CDD:278826
		RCC1	114..163	CDD:278826
		RCC1	167..218	CDD:278826
		RCC1	221..270	CDD:278826
		RCC1	273..322	CDD:278826
		RCC1_2	309..339	CDD:290274
		RCC1	327..390	CDD:278826
		HECTc	715..1060	CDD:238033	118/360 (33%)
		HECTc	739..1059	CDD:214523	110/334 (33%)
wwp-1	NP_740775.1	C2	29..147	CDD:301316
		WW	221..250	CDD:278809
		WW	255..284	CDD:278809
		WW	325..357	CDD:197736
		WW	367..398	CDD:197736	4/14 (29%)
		HECTc	440..792	CDD:238033	118/359 (33%)
		HECTc	463..791	CDD:214523	110/334 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910