DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Herc4 and nek8

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_620776.1	Gene:	nek8 / 171094	ZFINID:	ZDB-GENE-020509-1	Length:	697	Species:	Danio rerio

Alignment Length:	373	Identity:	109/373 - (29%)
Similarity:	178/373 - (47%)	Gaps:	56/373 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LYCWGSTSHGQLGLGGIEDEQILTPSQIPWTPDTAVQQVACGHRHTLFLTATGKVY-----ACGS 66
            :|.|||         ||.     ||.::|.. :|.|.||:.|....:.:|.:|::.     :.||
Zfish   322 VYTWGS---------GIS-----TPLRLPML-NTEVIQVSLGRTQKMGVTKSGRLITWEAPSVGS 371

  Fly    67 NDYSQLGHDLPTKRPRMSP-----FLLIPELQDYVIIQ-ICCGSRHSLALSDWGQVLSWGDNDCG 125
            .:.:     ||....:|.|     ||   |.|..|.|: :.||...:..|:|.|.::::|....|
Zfish   372 GEPT-----LPGAVEQMQPQFISRFL---EGQSGVTIKSVSCGDLFTTCLTDRGIIMTFGSGSNG 428

  Fly   126 QLGHATDKEIVQLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGSNIYGQLGVNSPNDLTH 190
            .|||....::.| ||:|..|:...:||::||.:|.||:|:..|::|||....|:||:.:.:  :|
Zfish   429 CLGHGNFNDVTQ-PKIVEALLGYELVQVSCGASHVLAVTNEREVFSWGRGDNGRLGLATQD--SH 490

  Fly   191 CNYPLRLTTLLGIPLAAIACGGNHSFLISKSGAVFGWGRNNCGQLGLNDETNRSYPT-------- 247
             |.|.:::.........:.||.:.|.::|....:...|.|...:|||:..:....|:
Zfish   491 -NCPQQVSLPADFEAQRVLCGVDCSMIMSTQHQILACGNNRFNKLGLDKVSGTEEPSSFCQVEEV 554

  Fly   248 ------QLKTLRTLGVRFVACGDEFSVFLTNEGGVFTCGAGAYGQLGHGFSSNEMLPRMVMELMG 306
                  |...|.|..:.::..|...||.:|.:|..||.|:..:||||.....:..:|..|..|.|
Zfish   555 HLFQLVQSAPLNTEKIVYIDIGTAHSVAVTEKGQCFTFGSNQHGQLGCSHRRSSRVPYQVSGLQG 619

  Fly   307 STITQVACGNRHTLALVPSRGRVYAFGLGSSGQLGTRSTKSLMLPQVV 354
              ||..|||:..||| :.:.|.||.:|.|:.|:|| |..:...:|:.|
Zfish   620 --ITMAACGDAFTLA-IGAEGEVYTWGKGARGRLG-RKEEDFGIPKPV 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826	14/47 (30%)
		RCC1	59..110	CDD:278826	15/61 (25%)
		RCC1	114..163	CDD:278826	17/48 (35%)
		RCC1	167..218	CDD:278826	13/50 (26%)
		RCC1	221..270	CDD:278826	12/62 (19%)
		RCC1	273..322	CDD:278826	19/48 (40%)
		RCC1_2	309..339	CDD:290274	13/29 (45%)
		RCC1	327..390	CDD:278826	11/28 (39%)
		HECTc	715..1060	CDD:238033
		HECTc	739..1059	CDD:214523
nek8	NP_620776.1	STKc_Nek8	3..258	CDD:270859
		S_TKc	4..255	CDD:214567
		ATS1	309..662	CDD:227511	108/370 (29%)
		RCC1 1	417..468		19/51 (37%)
		RCC1 2	469..520		14/53 (26%)
		RCC1 3	521..586		13/64 (20%)
		RCC1 4	587..636		20/51 (39%)
		RCC1 5	637..689		11/28 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920