DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Herc4 and Magi1

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	XP_006505643.1	Gene:	Magi1 / 14924	MGIID:	1203522	Length:	1484	Species:	Mus musculus

Alignment Length:	317	Identity:	63/317 - (19%)
Similarity:	101/317 - (31%)	Gaps:	87/317 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 VNSPNDLTH-CNYPLRLTTLLGIPLAAIACGGNHSF--LISKSGAVFGWGRNNCGQLGLNDETNR 243
            |.||....| .|.|..||.....|.     |..:|.  :.|.||:..|.|....|..|:.....:
Mouse   929 VPSPASSHHSSNQPASLTEEKRTPQ-----GSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSAVLQ 988

  Fly   244 SYPTQLKTLRTLGVRFVACGDEFSVFLTNEGGVF---TCGAGAY--GQLGHGFSSNE----MLPR 299
            .|..:::.....|..||...   ||.....|..|   .|.|..:  |::..|..::.    .:..
Mouse   989 PYDVEIRRGENEGFGFVIVS---SVSRPEAGTTFAGNACVAMPHKIGRIIEGSPADRCGKLKVGD 1050

  Fly   300 MVMELMGSTITQVA----------CGNRHTLALVPSRGRVYAFGLGSS------------GQLGT 342
            .::.:.|.:||..:          .||..||.::|......|..|.::            .|.||
Mouse  1051 RILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHAPSQQGT 1115

  Fly   343 RSTKSLMLPQ-----VVIGPWVSPS---------------GSALLQSNDSQVSLVIRQIFSGGDQ 387
            :.|::...|:     ...||..:..               |.:|....:..:.|.:.::...|
Mouse  1116 QETRTTTKPKQDSQFEFKGPQAAQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDG-- 1178

  Fly   388 SIVTTTLFVDKVPPEDFRNYNPKSQILTLTAEVTKQCAQCKQGLQSDMDLLSSIELI 444
                        |.|.........:||.:..|.||           :|....:||||
Mouse  1179 ------------PAERCGKMRIGDEILEINGETTK-----------NMKHSRAIELI 1212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826
		RCC1	59..110	CDD:278826
		RCC1	114..163	CDD:278826
		RCC1	167..218	CDD:278826	11/38 (29%)
		RCC1	221..270	CDD:278826	12/48 (25%)
		RCC1	273..322	CDD:278826	13/67 (19%)
		RCC1_2	309..339	CDD:290274	9/51 (18%)
		RCC1	327..390	CDD:278826	13/94 (14%)
		HECTc	715..1060	CDD:238033
		HECTc	739..1059	CDD:214523
Magi1	XP_006505643.1	PDZ_signaling	15..100	CDD:238492
		GuKc	122..293	CDD:214504
		WW	302..331	CDD:366073
		WW	362..393	CDD:197736
		PDZ	462..548	CDD:214570
		PDZ	633..716	CDD:214570
		MAGI_u5	715..798	CDD:374709
		PDZ_signaling	840..915	CDD:238492
		PDZ_signaling	989..1084	CDD:238492	19/97 (20%)
		PDZ	1145..1227	CDD:214570	16/93 (17%)
		PRK12678	1203..>1452	CDD:237171	5/10 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900