DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Herc4 and PLEKHA7

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	XP_024304124.1	Gene:	PLEKHA7 / 144100	HGNCID:	27049	Length:	1365	Species:	Homo sapiens

Alignment Length:	329	Identity:	69/329 - (20%)
Similarity:	108/329 - (32%)	Gaps:	103/329 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 GLNDETNR-SYPTQLKTLRTLGVRFVACGDEFSVFLTNEGGVFTCGAGAYGQLGHGFSSNEMLPR 299
            |||.|::: ::|.....|..|     ..||.                    |.|. .|:.|.|.|
Human  1109 GLNAESSKATFPRPKSALERL-----YSGDH--------------------QRGK-MSAEEQLER 1147

  Fly   300 MVMELMGSTITQVACGNRHTLALVPSRGRVYAFGLGSSGQLGTRSTKSLMLP-QVVIGPWVSPSG 363
            |               .||..|||..|.|.    ||...:.|..|::.|..| ...:|.|
Human  1148 M---------------KRHQKALVRERKRT----LGQGERTGLPSSRYLSRPLPGDLGSW----- 1188

  Fly   364 SALLQSNDSQVSLVIRQIFSGGDQSIVTTTLFVDKVPPEDFRNYNPKSQILTLTAEVTK--QCAQ 426
               .:..|..:.|:.|.:............|.|..:|..:. :..|:...|.::.|::|  :.:.
Human  1189 ---KREQDFDLQLLERVVQGEKKDKEENGWLKVQAMPVTEL-DLEPQDYDLDISRELSKPEKVSI 1249

  Fly   427 CKQGLQSDMDLLSSIE--------------LIFRSQACWNGSFLLDHDRHFGCSVRNHGLDLKAA 477
            .::.::.|.:...|:|              ::.||..| |.......|       :|...||
Human  1250 PERYVELDPEEPPSLEELQARYRKAEKIRNILARSSMC-NLQPTSGQD-------QNSVADL--- 1303

  Fly   478 QLAFDNLRAVENESIRQVIWDNITKELVGSLVCSPADVESMRLYLL----------LPLYHEFVN 532
                 :|:..|.|.|     .||:..|..........|.:.:|.||          :|.|..|.|
Human  1304 -----DLQLQEQERI-----INISYALASEASQRSKQVAAQQLALLPPKGPLSSRTVPPYPPFTN 1358

  Fly   533 SKHY 536
            ..||
Human  1359 GLHY 1362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826
		RCC1	59..110	CDD:278826
		RCC1	114..163	CDD:278826
		RCC1	167..218	CDD:278826
		RCC1	221..270	CDD:278826	9/34 (26%)
		RCC1	273..322	CDD:278826	9/48 (19%)
		RCC1_2	309..339	CDD:290274	9/29 (31%)
		RCC1	327..390	CDD:278826	12/63 (19%)
		HECTc	715..1060	CDD:238033
		HECTc	739..1059	CDD:214523
PLEKHA7	XP_024304124.1	WW	11..40	CDD:306827
		WW	56..85	CDD:306827
		PH_PEPP1_2_3	159..281	CDD:270068
		NESP55	<299..460	CDD:115071
		DUF1640	779..905	CDD:311647
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900