DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Herc4 and HECTD2

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_001271203.2	Gene:	HECTD2 / 143279	HGNCID:	26736	Length:	780	Species:	Homo sapiens

Alignment Length:	754	Identity:	223/754 - (29%)
Similarity:	353/754 - (46%)	Gaps:	101/754 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   384 GGDQSIVTTTLFVDKVPP--EDFRNYNPKSQILTLTAEVTKQ----CAQCKQGLQSDMDLLSS-- 440
            |....|.|.:.|:..|.|  |...|.:..:.::....:..::    |...:|..::.||..||
Human    51 GAKGQISTFSSFISAVSPKKEAAENRSSPAHLVFPNIKNVREPPPICLDVRQKQRTSMDASSSEM 115

  Fly   441 -----------------------IELIFRSQACW-----------------NGSFLLDHDRHFGC 465
                                   :|.: :|...|                 |.:|..|....|.
Human   116 KAPVLPEPILPIQPKTVKDFQEDVEKV-KSSGDWKAVHDFYLTTFDSFPELNAAFKKDATASFN- 178

  Fly   466 SVRNHGLDLKAAQLAFDNLRAVENESIRQVIWDNITKELVGSLV---CSPADVESMRLYLLLPLY 527
            ::.:.|::.|.....:|.|.     :..|.:...:.|.::.||:   ..|...:.:|.|.:|...
Human   179 TIEDSGINAKFVNAVYDTLL-----NTPQDVQKTVLKGIINSLLREWKGPRTKDDLRAYFILLQN 238

  Fly   528 HEFVNSKHYKSLQVPFANAIFKLA---ENPRKVLNKWL----AQTPAEYFEHLVQNFLHVVIHII 585
            .:|.|:..|    |.:|:.:.::|   |.....|..|.    ::...:.|:.||:..|..:
Human   239 PQFNNTSTY----VIYAHLLRQIATLVEADHHFLVHWFKKQYSRLSQKRFKQLVERLLQFI---- 295

  Fly   586 SFKMGLAAASPSAERRQQLLPYNTELEIILKLMKTLCQINNERHDRL-NYQIFYWPDLSDYADVQ 649
              .:.|..|.|  |....:...:..:....|::..|...||..|..| .|..||...| |:.|:.
Human   296 --SLRLFPAKP--EEFPPITKCSWWIPSAAKVLALLNTANNLVHPPLIPYTDFYNSTL-DHIDLM 355

  Fly   650 QEYVKWIMADTARDFNICNYSFIFDQSAKTALLQADQALQMHSAMANAATMAFSFFNYGMPISQF 714
            :||..|.....:..|:.|.|.|:...:||..::|.|...||.:....:.....|  ....|....
Human   356 EEYHTWQNFGNSHRFSFCQYPFVISVAAKKIIIQRDSEQQMINIARQSLVDKVS--RRQRPDMNI 418

  Fly   715 IVLN--VTRENLVQDSLRELQHYSQSDLKKPLKIKFHGEEAEDAGGVRKEFFMLLLKDLLDPKYG 777
            :.||  |.|.:||.|||.||.. .::||||.||:.|.||...|.||:.||:|:||::.:..|.||
Human   419 LFLNMKVRRTHLVSDSLDELTR-KRADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYG 482

  Fly   778 MFKEYEQSRLLWFADLTFETENMYFLIGVLCGLAIYNFTIINLPFPLALFKKLLGKP-------- 834
            ||..::.|...||:....:..:.:.|:|:|.|||:||...:::.||...:||||..|
Human   483 MFTYHKDSHCHWFSSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKLLSPPIIPSDQNI 547

  Fly   835 ------VDLSDLRQLSPPEANSMQSLLDYQGDDFKEVFDLTFEISRDVFGEAETKCLKPNGNEIA 893
                  |.:.||.|:.|..|:.:..||.::| :.:|.|..||::.::.||..::..|||.|::|:
Human   548 PVGICNVTVDDLCQIMPELAHGLSELLSHEG-NVEEDFYSTFQVFQEEFGIIKSYNLKPGGDKIS 611

  Fly   894 VTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQAL 958
            ||.:||:|:|.||.||:.|||:...:.||:.||..||:...:.:.:|||:..:|.|:.|.|..||
Human   612 VTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALMLLRPEEVEILVCGSPDLDMHAL 676

  Fly   959 QDNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKALKLTIQPT-PDER 1022
            |.:.:| :||...|.|||:||:|:.......:|..|.|.|||||:|:.||..|...|... ....
Human   677 QRSTQY-DGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFTTGSDRVPVGGMADLNFKISKNETSTN 740

  Fly  1023 FLPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGFSL 1061
            .|||||||||.|.||.||:|:.||.||:..|..::||.|
Human   741 CLPVAHTCFNQLCLPPYKSKKDLKQKLIIGISNSEGFGL 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826
		RCC1	59..110	CDD:278826
		RCC1	114..163	CDD:278826
		RCC1	167..218	CDD:278826
		RCC1	221..270	CDD:278826
		RCC1	273..322	CDD:278826
		RCC1_2	309..339	CDD:290274
		RCC1	327..390	CDD:278826	1/5 (20%)
		HECTc	715..1060	CDD:238033	144/361 (40%)
		HECTc	739..1059	CDD:214523	132/334 (40%)
HECTD2	NP_001271203.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46
HECTD2	NP_001271203.2	HECTc	421..778	CDD:238033	144/359 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276447at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R774
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850