DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Herc4 and Plekha5

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	XP_006506926.1	Gene:	Plekha5 / 109135	MGIID:	1923802	Length:	1270	Species:	Mus musculus

Alignment Length:	707	Identity:	128/707 - (18%)
Similarity:	207/707 - (29%)	Gaps:	272/707 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   291 FSSNEMLPRMVMELMGSTITQVACGNRHTLALVPSRGRVYAFGLGSSGQLGTRS--TKSLMLPQV 353
            :.....|||.........:.||:....|::...||.|...|: .|.|.|...||  |..:....|
Mouse   518 YHKQSTLPRHGCLSSPKAMVQVSDQTMHSIPTSPSHGSAAAY-QGFSPQRTYRSEVTSPIQRGDV 581

  Fly   354 VIGPWVSPSGSALLQSNDSQVSLVIRQIFSGGDQSIVTTTLFVDKVPPEDFRNYNPKSQILTLTA 418
            .|.....|       .:...|.:..|:....|        |.:..|.|:..:...|: ::..|..
Mouse   582 TIDRRHRP-------HHPKHVYVADRRSMPAG--------LTLQAVSPQSLQGRTPE-ELTLLLI 630

  Fly   419 EVTKQCAQCKQGLQSDMDLLSSIELIFRSQACWNGSFLLDHDRHFGCSVRNHGLDLKAAQLAFDN 483
            ::.:|.|:..                                     |||.|.|    |||....
Mouse   631 KLRRQQAELS-------------------------------------SVREHTL----AQLMQLK 654

  Fly   484 LRA--VENESIRQVIWDNITKELVGSLVCSPADVESMRLYLLLPLYHEFVNSKHYKSLQVPFANA 546
            |.|  .:||.:...:..|                   .:||           .|......|....
Mouse   655 LEAHSPKNEILSHHLQRN-------------------TIYL-----------DHQMKENEPIITM 689

  Fly   547 IFKLAENPRKVLNKWLAQTPAEYFEHLVQNFLHVVIHIISFKMGLAAASPSAERRQQLLPYNTEL 611
            :..:.||.        |..|..|.:.|.|          ..|:.|...|.. |.|..|..|..|.
Mouse   690 VHTMIENS--------ALRPQLYQQFLRQ----------KNKISLYCLSQD-ECRGTLYKYRPEE 735

  Fly   612 EIILKLMKTLCQINNERHDRLNYQIFYWPDLSDYADVQQEYVKWIMADTARDFNICNYSFIFDQS 676
            ..|...:..||                          :|:.|...:.:..:..:...|:.
Mouse   736 AGIDAKLSRLC--------------------------EQDKVVRALEEKLQQLHKEKYTL----- 769

  Fly   677 AKTALLQADQALQMHSAMANAATMAFSFFNYGMPISQFIVLNVTRENLVQDSL----RELQHYSQ 737
             :.|||.|.|.::|::  .|.|.:            |.:||.  |::| |:.|    |||.. :.
Mouse   770 -EQALLSASQEIEMNA--DNPAAI------------QTVVLQ--RDDL-QNGLLSTCRELSR-AT 815

  Fly   738 SDLKKPL----KIKFH---------------GEEAEDAGGVRKEFFMLLLKDLLDPKYGMFKEYE 783
            ::|::..    |:::.               ||...::.|:::......|..:.|...|:.|..:
Mouse   816 AELERAWREYDKLEYDVTVTRDQMQGQLDRLGEVQSESAGIQRAQIQKELWRIQDVMEGLSKHKQ 880

  Fly   784 QSRLLWFADLTFETENMYFLIGVLCGLAIYNFTIINLPFPLALFKK----------LLGKPVDLS 838
            |..       :.||      :| |.|         :.||....:|.          .|.:..|.:
Mouse   881 QRG-------SSET------VG-LAG---------SKPFSSVKYKSEEEEVVPPRPPLPRSYDFT 922

  Fly   839 DLRQLSPPEANSMQSLLDYQ-------------------------GDDFK------------EVF 866
            :...:.||..:...|||.|.                         |.|::            ||.
Mouse   923 EQPPIIPPLPSDSSSLLCYSRGPVHLPEDKKIHQVQGYPRNGSHCGPDYRLYKSEPELTTVAEVD 987

  Fly   867 DLTFEISRDVFGEAE----------------TKCLKPNGNEIA--VTLENRQEFVDL 905
            :...|...:...|.|                ||...|..:.||  |||...::.|:|
Mouse   988 ESNGEEKSEPVSETEAPVVKGSHFPVGVPLRTKSPTPESSTIASYVTLRKTKKMVEL 1044

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826
		RCC1	59..110	CDD:278826
		RCC1	114..163	CDD:278826
		RCC1	167..218	CDD:278826
		RCC1	221..270	CDD:278826
		RCC1	273..322	CDD:278826	6/30 (20%)
		RCC1_2	309..339	CDD:290274	9/29 (31%)
		RCC1	327..390	CDD:278826	14/64 (22%)
		HECTc	715..1060	CDD:238033	52/279 (19%)
		HECTc	739..1059	CDD:214523	43/251 (17%)
Plekha5	XP_006506926.1	WW	13..42	CDD:366073
		WW	59..88	CDD:366073
		PH_PEPP1_2_3	165..268	CDD:270068
		Smc	<623..>864	CDD:224117	64/381 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900