DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Herc4 and Rcbtb2

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_001164165.1	Gene:	Rcbtb2 / 105670	MGIID:	1917200	Length:	551	Species:	Mus musculus

Alignment Length:	558	Identity:	149/558 - (26%)
Similarity:	230/558 - (41%)	Gaps:	111/558 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 LFLTATGKVYACGSNDYSQLG-HDL-PTKRPRMSPFLLIPELQDYVIIQICCGS-RHSLALSDWG 114
            |:.|...:::..|:|....|| .|: .|..||.     :..|....|..:..|| .|.:..:..|
Mouse    59 LYTTVNDEIFVLGTNCSGCLGVGDIQSTIEPRR-----LDSLTGKKIASLSYGSGPHIVLATTDG 118

  Fly   115 QVLSWGDNDCGQLGHATDKEIVQLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGSNIYGQ 179
            :|.:||.|...|||:.|....:....:...|..|.|:::|||:.|||.|||.||:::||.|..||
Mouse   119 EVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQ 183

  Fly   180 LGVNS------PNDLTHCNYPLRLTTLLGIPLAAIACGGNHSFLISKSGAVFGWGRNNCGQLGLN 238
            :|..|      |..:|.|        |....:..||||...|..:..:|.|:.||.|..|||||.
Mouse   184 VGSGSTANQPIPRRVTGC--------LQNKVVMNIACGQMCSMAVVDTGEVYVWGYNGNGQLGLG 240

  Fly   239 DETNRSYPTQLKTLRTLGVRFVACGDEFSVFLTNEGGVFTCGAGAYGQLGHGFSSNEMLPRMVME 303
            ...|:..|.::..|:.:.|:.||||...::.||:||.::..||.:|||||.|..||:..|..|:.
Mouse   241 SSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPVVV 305

  Fly   304 LMGSTITQVACGNRHTLALVPSRGRVYAFGLGSSGQLGTRSTKSLMLPQVVIGPWVSPSGSALLQ 368
            .....|...||.:.||.|.....|.||.:| ...||       |::||.          .:....
Mouse   306 EKDRIIEIAACHSAHTSAAKTQGGHVYMWG-QCRGQ-------SVILPH----------HTHFCC 352

  Fly   369 SNDSQVSLVIRQIFSGGDQSIVTTTLFVDKVPPEDFRNYNPKSQILTLTAEVTKQCAQCKQGLQS 433
            ::|         :|:......||..|.  .|.|:|.         ||:.           :.|:.
Mouse   353 TDD---------VFACFATPAVTWRLL--SVEPDDH---------LTVA-----------ESLKR 386

  Fly   434 DMDLLSSIELIFRSQACWNGSFLLDHD-------RHFGCSVRNHGLDL-KAAQLAFDNLRAVENE 490
            :.|...:.:|.|    ..:|.::..|.       .||..|:.:...|: :.::.::...||.
Mouse   387 EFDNPDTADLKF----LVDGKYIYAHKVLLKIRCEHFRSSLEDSEDDIVEMSEFSYPVFRAF--- 444

  Fly   491 SIRQVIWDNIT---KELVGSLVCSPADVESMRLYLLLPLYHEFVNSKHYKSLQVPFANAIFKLAE 552
             :..:..|||:   :|.||                ||.|...:..::..|..|......|.:  |
Mouse   445 -LEYLYTDNISLSPEEAVG----------------LLDLATFYSETRLKKLCQQTIKQGICE--E 490

  Fly   553 NPRKVLN---KWLAQTPAEYFEHLVQNFLHVVIHIISF 587
            |...:|:   |:.||...|:......|.|.||.....|
Mouse   491 NAIALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGF 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826	1/1 (100%)
		RCC1	59..110	CDD:278826	13/53 (25%)
		RCC1	114..163	CDD:278826	18/48 (38%)
		RCC1	167..218	CDD:278826	18/56 (32%)
		RCC1	221..270	CDD:278826	18/48 (38%)
		RCC1	273..322	CDD:278826	19/48 (40%)
		RCC1_2	309..339	CDD:290274	10/29 (34%)
		RCC1	327..390	CDD:278826	11/62 (18%)
		HECTc	715..1060	CDD:238033
		HECTc	739..1059	CDD:214523
Rcbtb2	NP_001164165.1	RCC1 1. /evidence=ECO:0000255	64..115		13/55 (24%)
		ATS1	<107..335	CDD:227511	84/235 (36%)
		RCC1 2. /evidence=ECO:0000255	117..169		19/51 (37%)
		RCC1 3. /evidence=ECO:0000255	171..222		18/58 (31%)
		RCC1 4. /evidence=ECO:0000255	223..274		19/50 (38%)
		RCC1 5. /evidence=ECO:0000255	276..326		19/49 (39%)
		RCC1 6. /evidence=ECO:0000255	328..382		19/102 (19%)
		BTB_POZ_RCBTB2_CHC1L	374..490	CDD:349663	28/161 (17%)
		BACK_RCBTB2	487..551	CDD:350604	13/44 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920