DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Herc4 and Ube3c

DIOPT Version :9

Sequence 1:NP_001261249.1 Gene:Herc4 / 38151 FlyBaseID:FBgn0035207 Length:1062 Species:Drosophila melanogaster
Sequence 2:NP_598668.1 Gene:Ube3c / 100763 MGIID:2140998 Length:1083 Species:Mus musculus


Alignment Length:805 Identity:191/805 - (23%)
Similarity:309/805 - (38%) Gaps:247/805 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   401 PEDFRNYNPKSQILTLTAEVTKQCAQ---CKQGLQSDMDLL---SSIELIFRSQACWNGSFLLDH 459
            |||.|...|         .:|::|.:   .||...:.::|:   |:.|.:|...|....:.::.|
Mouse   381 PEDGRVSAP---------YITEECLRKLDTKQQTNTLLNLVWRDSASEEVFTRMASICHTLMVQH 436

  Fly   460 DRHFGCSVRNHGLDLKAAQLAFDNLRAVENESIRQVIWDNI----TKELVGSLV--------CSP 512
             |.....||      ....||| |.|.:.:      :|..|    |:.:.||:|        .||
Mouse   437 -RMMVPKVR------LLYSLAF-NARFLRH------LWFLISSMTTQMITGSMVPLLQLISRGSP 487

  Fly   513 ADVE-SMRLYLLLPLYHEFVNSKHYKSLQVPFANAIFKLAENPRKVLNKWLAQTPAEYFEHLVQN 576
            ...| |.|   ::||::.|      .||   |::::..:.:|              |:|...:: 
Mouse   488 MSFEDSSR---IIPLFYLF------SSL---FSHSLISIHDN--------------EFFGDPIE- 525

  Fly   577 FLHVVIHIISFKMGLAAASPSAERRQQLLPYNTELEIIL--KLMKTLCQINNERHDRLNYQIFYW 639
               ||                .:|:..::|:..| |:||  :.::..|         |......:
Mouse   526 ---VV----------------GQRQSSMMPFTLE-ELILLSRCLRDAC---------LGIIKLAY 561

  Fly   640 PDLSDYADVQQEYV-----------------------KWIM--------------ADTARDFNIC 667
            |:..  .:|::|||                       :|:.              .||.|:|...
Mouse   562 PETK--PEVREEYVTAFQSIGVTTNSEMQQCIQMEQKRWVQLFKVITNLVKMLKSRDTRRNFCPP 624

  Fly   668 NYSFIFDQSAKTALLQADQALQMHSAMANAATMAFSFFNYG---------------MPIS----- 712
            |: ::.:|..    ::||:..|::   ..|:...:.|...|               :|:|     
Mouse   625 NH-WLSEQED----IKADKVTQLY---VPASRHVWRFRRMGRIGPLQSTLEVGLESLPLSVSEER 681

  Fly   713 --------QFIV-----------------------------LNVT--RENLVQDSLRELQHYSQS 738
                    .|:|                             :|||  |..:.:|:..:|...::.
Mouse   682 QLAILTELPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEP 746

  Fly   739 DLKKPLKIKF---HG--EEAEDAGGVRKEFFMLLLKDLLDPKYGMFKEYEQSRLLW--------- 789
            ||||.:::..   ||  |...|.||:.:||...|||...:|..|.||...:. ||:         
Mouse   747 DLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEG-LLYPNPAAQMLV 810

  Fly   790 ---FADLTFETENMYFLIGVLCGLAIYNFTIINLPFPLALFKKLLG--KPVDLSDLRQLSPPEAN 849
               ||       ..|:.:|.:.|.|:|...::.|||......||||  ..||:..|..|.|....
Mouse   811 GDSFA-------RHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYR 868

  Fly   850 SMQSLLDYQGDDFKEVFDLTFEISRDVFGEAETKCLKPNGNEIAVTLENRQEFVDLYVDFVFNKS 914
            ::..|..|:.|  .|...|.|.:..:..|||:...||..|.:|.||..||..::.|..|:..||.
Mouse   869 NLLFLKSYEED--VEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTGANRIAYIHLVADYRLNKQ 931

  Fly   915 VELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVGNE-DYDWQALQDNCEYREGYTSVDDTIKWF 978
            :..|..||.:|...|.|...:.:|..:|:..::.|.: ....:.|:....|..||::....||.|
Mouse   932 IRPHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPVSLEDLKSFTNYSGGYSADHPVIKIF 996

  Fly   979 WEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKALKLTIQPT-------PDERFLPVAHTCFNLLDL 1036
            |.|:...::.||:..|.|:|...|.|:.|.|.|    .|.       .|...||.|.||.|||.|
Mouse   997 WRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKEL----YPAFCIHNGGSDLERLPTASTCMNLLKL 1057

  Fly  1037 PRYKTKERLKYKLLQAIQQTQGFSL 1061
            |.:..:..|:.|||.||:...||.|
Mouse  1058 PEFYDEALLRSKLLYAIECAAGFEL 1082

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Herc4NP_001261249.1 RCC1 6..55 CDD:278826
RCC1 59..110 CDD:278826
RCC1 114..163 CDD:278826
RCC1 167..218 CDD:278826
RCC1 221..270 CDD:278826
RCC1 273..322 CDD:278826
RCC1_2 309..339 CDD:290274
RCC1 327..390 CDD:278826
HECTc 715..1060 CDD:238033 115/402 (29%)
HECTc 739..1059 CDD:214523 107/346 (31%)
Ube3cNP_598668.1 Cis-determinant of acceptor ubiquitin-binding. /evidence=ECO:0000250 1..60
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..40
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 354..386 3/4 (75%)
HECTc 723..1081 CDD:238033 114/371 (31%)
HECTc 747..1080 CDD:214523 107/346 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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