DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Herc4 and herc3

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	XP_002938676.3	Gene:	herc3 / 100488790	XenbaseID:	XB-GENE-968537	Length:	1050	Species:	Xenopus tropicalis

Alignment Length:	1078	Identity:	470/1078 - (43%)
Similarity:	668/1078 - (61%)	Gaps:	52/1078 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LYCWGSTSHGQLGLGGIEDEQILTPSQIPWTPDTAVQQVACGHRHTLFLTATGKVYACGSNDYSQ 71
            :.|||.::.||||.|......:..|....::....|::||||.:|||||...|:||:||.|...|
Frog     1 MLCWGHSTFGQLGNGHSFQGSVSDPCVCRFSLAACVKEVACGGKHTLFLLEDGQVYSCGWNGEGQ 65

  Fly    72 LGHDLPTKRPRMSPFLLIPELQDYVIIQICCGSRHSLALSDWGQVLSWGDNDCGQLGHATDKEIV 136
            ||||.....|     :.:..|.:..|..|.||..|:||||..||:.|||..:.|||||||.:...
Frog    66 LGHDHEGTDP-----VQVTTLTEEHITHIACGQSHNLALSYQGQLYSWGSGNDGQLGHATVEHSS 125

  Fly   137 QLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGSNIYGQLGVNSPNDLTHCNYPLRLTTLL 201
            ::|:::::|..:.:.|::|||:|.:||...|:|::||.|::||||:.  |.....:.|.|:.:|.
Frog   126 RIPRIIKKLNQQKIQQVSCGNDHCMALGDDGQLFTWGQNLHGQLGLG--NGFLSQSSPQRVKSLE 188

  Fly   202 GIPLAAIACGGNHSFLISKSGAVFGWGRNNCGQLGLNDETNRSYPTQLKTLRTLGVRFVACGDEF 266
            |||||.:..||:|||.:|.||||||||.|:.||||||||..|..|..:|.|||..|.:::||:|.
Frog   189 GIPLAQVTAGGSHSFALSLSGAVFGWGNNSAGQLGLNDEKVRETPCHVKPLRTHKVIYISCGEEH 253

  Fly   267 SVFLTNEGGVFTCGAGAYGQLGHGFSSNEMLPRMVMELMGSTITQVACGNRHTLALVPSRGRVYA 331
            :..||..||:||.|||..|||||...:||:.||.|:|||||.::|:|||.:||||.|||.|.:||
Frog   254 TAILTKAGGLFTFGAGGSGQLGHDSLNNEINPRRVLELMGSEVSQIACGRQHTLAFVPSSGTLYA 318

  Fly   332 FGLGSSGQLGTRSTKSLMLPQVVIGPWVSPSGSALLQSNDSQVSLVIRQIFSGGDQSIVTTTLFV 396
            ||.|..|||||....::..|.||.|.|.:.||...:.: |.....:::||||||:::.|..:...
Frog   319 FGCGDLGQLGTGHKNNVKCPAVVKGKWAAHSGQISMHA-DRAAYNIVKQIFSGGNKTFVLCSKLE 382

  Fly   397 DKVPPEDFR---NYNPKSQILTLTAEVTKQCAQCKQGLQSDMDLLSSIELIFRSQACWNGSFL-L 457
            ...|.:|||   ..|..|.|...|.:|.:|    |....|:.:.::.|.....|.|||||||| .
Frog   383 SSQPADDFRFCSQRNHTSVINEETIDVWRQ----KVLENSNTNSMNGIVQTLSSLACWNGSFLEK 443

  Fly   458 DHDRHFGCSVRNHGLDLKAAQLAFDNLRAVENESIRQVIWDNITKELVGSLVCSPADVESMRLYL 522
            .:|.||..|.:..|:::.:.::.|:.|..|.:..:.:.|.......|:..|..||.|||:||:|:
Frog   444 RNDEHFRTSPKIPGINMCSIKVLFEKLMNVHHSRLLEQILKGFESFLIPQLSSSPPDVEAMRIYI 508

  Fly   523 LLPLYHEFVNSKHYKSLQVPFANAIFKLAENPRKVLNKWLAQTPAEYFEHLVQNFLHVVIHIISF 587
            :||.:....:||:|.:|.:|.|.||.:|..||.|||:.|.||...:||..|:..:...|:::::
Frog   509 ILPEFPLLQDSKYYITLTLPLAMAILRLDTNPSKVLDNWWAQVCPKYFLKLISLYKEAVVYLLN- 572

  Fly   588 KMGLAAASPSAERRQQLLP--YNTELEIILKLMKTLCQINNERHDRLNYQIFYWPDLSDYADVQQ 650
                       .|:..|:|  :.:.:...|||::.|.::|. :...:.:..||.|::|...|:|:
Frog   573 -----------GRKTLLIPVLFTSYITAALKLLEKLHKVNG-KAQHVEHDTFYIPEISSLVDIQE 625

  Fly   651 EYVKW------------IMADTARDFNICNYSFIFDQSAKTALLQADQALQMHSAMANAATMAFS 703
            :|:.|            ||.|:   ..:|:|.|:||..|||.:||.|..|||..|: |.|.:...
Frog   626 DYLMWFLNEAGLKLRPTIMQDS---ITLCSYPFVFDAQAKTKMLQTDAELQMQVAI-NGANLQNV 686

  Fly   704 FFNYGM-PI---SQFIVLNVTRENLVQDSLRELQHYSQSDLKKPLKIKFHGEEAEDAGGVRKEFF 764
            |....: |:   :.|:||:|.|.:||.|:||||..||..|||||||:.|.||||.|.|||.||||
Frog   687 FMLLTLDPMLVKNPFLVLHVRRTSLVADALRELSIYSDIDLKKPLKVIFDGEEAVDDGGVTKEFF 751

  Fly   765 MLLLKDLLDPKYGMFKEYEQSRLLWFADLTFETENMYFLIGVLCGLAIYNFTIINLPFPLALFKK 829
            :||||:||:|.||||..|:.|.||||:|:.|...|.:.|||::|||||||||:::|.|||||:||
Frog   752 LLLLKELLNPIYGMFTVYQDSNLLWFSDICFVEHNWFHLIGIMCGLAIYNFTVVDLYFPLALYKK 816

  Fly   830 LLGKPVDLSDLRQLSPPEANSMQSLLDYQGDDFKEVFDLTFEISRDVFGEAETKCLKPNGNEIAV 894
            ||.....|.||::|||.|..|:|.||||..||..:||.|.|.|.|:.:|.||.:.|...|:.|.|
Frog   817 LLNVQPTLEDLKELSPTEGRSLQELLDYPEDDVDDVFCLNFTICRESYGLAERRPLVAGGDHITV 881

  Fly   895 TLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQALQ 959
            |.:|||:|||.||::|||:||:..|.||..||:|||.|:::.:|||.||.::|||:.:|:||.|:
Frog   882 TKDNRQQFVDAYVNYVFNQSVQEWYEAFSTGFLKVCGGKILELFQPSELRSMVVGSNNYNWQELE 946

  Fly   960 DNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKALKLTIQP-TPDERF 1023
            :|..|:..|::...|::.|||..||....:||.|||||||||||||.||.:|::.||. :..|..
Frog   947 ENAIYKGDYSTAHPTVRMFWETFHDFPLEKKKKFLLFLTGSDRIPIYGMSSLRIIIQSISSGEDH 1011

  Fly  1024 LPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGFSL 1061
            |||||||:||||||:|.:||.|:.:|.|||...:||||
Frog  1012 LPVAHTCYNLLDLPKYSSKETLRRRLTQAIDHYEGFSL 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826	17/47 (36%)
		RCC1	59..110	CDD:278826	19/50 (38%)
		RCC1	114..163	CDD:278826	19/48 (40%)
		RCC1	167..218	CDD:278826	23/50 (46%)
		RCC1	221..270	CDD:278826	27/48 (56%)
		RCC1	273..322	CDD:278826	29/48 (60%)
		RCC1_2	309..339	CDD:290274	17/29 (59%)
		RCC1	327..390	CDD:278826	25/62 (40%)
		HECTc	715..1060	CDD:238033	190/345 (55%)
		HECTc	739..1059	CDD:214523	176/320 (55%)
herc3	XP_002938676.3	RCC1	3..49	CDD:395335	17/45 (38%)
		ATS1	44..353	CDD:227511	152/315 (48%)
		HECTc	702..1048	CDD:238033	190/345 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	352	1.000	Domainoid score	I1004
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	901	1.000	Inparanoid score	I375
OMA	1	1.010	-	-		QHG57432
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	1	1.000	-	-		FOG0001110
OrthoInspector	1	1.000	-	-		otm48443
Panther	1	1.100	-	-	LDO	PTHR45622
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X678
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080