Protein Alignment Herc4 and herc2

DIOPT Version :9

• Sequence 1: NP_001261249.1
• Gene: Herc4 / 38151
• FlyBaseID: FBgn0035207
• Length: 1062
• Species: Drosophila melanogaster
• Sequence 2: XP_012813154.2
• Gene: herc2 / 100487407
• XenbaseID: XB-GENE-1012659
• Length: 4848
• Species: Xenopus tropicalis
• Alignment Length: 1099
• Identity: 261/1099 - (23%)
• Similarity: 401/1099 - (36%)
• Gaps: 319/1099 - (29%)

  Fly     7 LYCWGSTSHGQLGLGGIEDEQILTPSQIPWTPDTA------VQQVACGHRHTLF-LTATGKVYAC 64
            :|.||....||  |||||..::..|     ||..|      ||.:  |...||| :||.||:||.
 Frog  3968 IYGWGHNHRGQ--LGGIEGAKVKVP-----TPCEALATLRPVQLI--GGEQTLFAVTADGKLYAT 4023

  Fly    65 GSNDYSQLG------HDLPTKRPRMSPFLLIPELQDYVI--IQICCGSRHSLALSDWGQVLSWGD 121
            |.....:||      ...||         |:..:|...|  :.:..|.:|.||||..|:|.|||:
 Frog  4024 GYGAGGRLGIGGTESVSTPT---------LLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGE 4079

  Fly   122 NDCGQLGHATDKEIVQLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGSNIYGQLGVNSPN 186
            .:.|:|||. ::.....|:|:..|....||.||.|..||..:|:.||||:||...||:||.....
 Frog  4080 AEDGKLGHG-NRSPCDRPRVIESLRGTEVVDIAAGGAHSACITAAGELYTWGKGRYGRLGHGDSE 4143

  Fly   187 DLTHCNYPLRLTTLLGIPLAAIACGGN--HSFLISKSGAVFGWGRNNCGQLGLNDETNRSYPTQL 249
            |...   |..:..|.|..:..||||..  .:..::....|:.||..:.|:||.........|.::
 Frog  4144 DQLK---PKLVEALQGYRVIDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKI 4205

  Fly   250 KTLRTLGVRFVACGDEFSVFLTNEGGVFTCGAGAYGQLGHGFSSNEMLPRMVMELMGSTITQVAC 314
            .:|..:||..|.||.:|||.||..|.|:|.|.|.|.:||||...:...||.|..|.|..:..:|.
 Frog  4206 DSLTGVGVTKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIAT 4270

  Fly   315 GNRHTLALVPSRGRVYAFGLGSSGQLGTRSTKSLMLPQVVIGPWVSPSGSALLQSNDSQVSLVIR 379
            |:.|.:..... |.||.:|....||||..:|.::..|::|          |.||...      |.
 Frog  4271 GSLHCVCCTED-GEVYTWGDNDEGQLGDGTTNAIQRPRLV----------AALQGKK------IN 4318

  Fly   380 QIFSGGDQSIVTTT---LFVDKVPPEDFRNYNPKSQILTLTAEVTKQCAQCKQGLQSDMDLLSSI 441
            ::..|...::..:|   ....|:|.:....||...:|:.:             .|::.:.||..|
 Frog  4319 RVACGSAHTLAWSTSKPANAGKLPSQVPMEYNHLQEIMII-------------ALRNRLLLLHHI 4370

  Fly   442 ELIFRSQAC-----WNGSFLLDHDRHFGCSVRNHGLDLKAAQLAFDNLRAV-----ENESIRQVI 496
            ..:|    |     ::....||...             :...:.||.||.:     :..:.|:|:
 Frog  4371 SELF----CPCIPMFDLEGRLDESG-------------QGPSIGFDTLRGILISQGKEAAFRKVV 4418

  Fly   497 WDNITKELVGSLVCSPADVESMRLYLLLPLYHEFVNSKHYKSLQVPFANAIFKLAENPRKVLNKW 561
            ...:.::.....|     ||..|:.:           |..:|
 Frog  4419 QATMVRDRQHGPV-----VELNRIQV-----------KRSRS----------------------- 4444

  Fly   562 LAQTPAEYFEHLVQNFLHVVIHIISFKMGLAAASPSAERRQQLLPYNTELEIILKLMKTLCQINN 626
                                      |.|||.
 Frog  4445 --------------------------KGGLAG--------------------------------- 4450

  Fly   627 ERHDRLNYQIFYWPDLSDYADVQQEYVKWIMADTARDFNICNYSFIFDQ-SAKTALLQADQALQM 690
                         ||                          ....:|.| .||.|....|..|..
 Frog  4451 -------------PD--------------------------GTKSVFGQMCAKMASFSPDSLLLP 4476

  Fly   691 HSAMANAATMAFSFFNYGMPISQFIVLNVTRENLVQDSLRELQHYSQSDLKKPLKIKFHGEEAED 755
            |                                                  :..|:||.||..:|
 Frog  4477 H--------------------------------------------------RVWKVKFVGESVDD 4491

  Fly   756 AGGVRKEFFMLLLKDLLDPKYGMFKEYEQSR----------LLWFADLTFETENMYFLIGVLCGL 810
            .||...|....:.::|.:....:.......|          ||..|..|....||:..:|||.|:
 Frog  4492 CGGGYSESIAEMCEELQNGLTPLLIVTPNGRDESGANRDCFLLNPAAKTTLHMNMFRFLGVLLGI 4556

  Fly   811 AIYNFTIINLPFPLALFKKLLGKPVDLSDLRQLSPPEANSMQSLLDYQ--GDDFKEVFDLTFEIS 873
            ||...:.::|.....::|:|.|..:.::||.::.......:..:.|.:  .::| |...|.|.:.
 Frog  4557 AIRTGSPLSLNLAEPVWKQLAGMNLTIADLSEVDKDFIPGLMYIRDNEATSEEF-EAMILPFTVP 4620

  Fly   874 RDVFGEAETKCLKPNGNEIAVTLENRQEFVDLYVDF---VFNKSVELHYNAFHKGFMKVCSGRVI 935
                 .|..:.::.:.....:||:||.|:|.|.:.:   .|::.|.    |..:|..:|....::
 Frog  4621 -----SASGQDIQLSSKHTHITLDNRAEYVRLAIGYRLHEFDEQVA----AVREGMARVVPVPLL 4676

  Fly   936 HIFQPEELMAVVVGNEDYDWQALQDNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGS 1000
            .:|...||..:|.|:.|.....|:....|: |.......|:|||:|:...|..|:..||.|:.|.
 Frog  4677 SLFTGYELETMVCGSPDIPLHLLKSVATYK-GIEPTASLIQWFWDVMESFSNTERSLFLRFVWGR 4740

  Fly  1001 DRIP--IQGMKALKLTIQP----TPDERFLPVAHTCFNLLDLPRYKTKERLKYKLLQAI 1053
            .|:|  |...:.....||.    .|.:.|||.::|||.||.||||..|:.|:.||..||
 Frog  4741 TRLPRTIADFRGRDFVIQVLDKYNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAI 4799

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826	20/54 (37%)
		RCC1	59..110	CDD:278826	15/58 (26%)
		RCC1	114..163	CDD:278826	19/48 (40%)
		RCC1	167..218	CDD:278826	18/52 (35%)
		RCC1	221..270	CDD:278826	16/48 (33%)
		RCC1	273..322	CDD:278826	18/48 (38%)
		RCC1_2	309..339	CDD:290274	7/29 (24%)
		RCC1	327..390	CDD:278826	16/62 (26%)
		HECTc	715..1060	CDD:238033	91/360 (25%)
		HECTc	739..1059	CDD:214523	91/336 (27%)
herc2	XP_012813154.2	ATS1	<501..794	CDD:227511
		Cyt-b5	1219..1291	CDD:395121
		MIB_HERC2	1879..1939	CDD:399589
		UBA_HERC2	2471..2518	CDD:270585
		Cul7	2566..2643	CDD:402903
		SH3_15	2651..2708	CDD:408152
		ZZ_HERC2	2718..2762	CDD:239084
		APC10-HERC2	2777..2922	CDD:176485
		ATS1	2968..3334	CDD:227511
		ATS1	4037..4342	CDD:227511	103/334 (31%)
		HECTc	4435..4806	CDD:238033	108/558 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920