DRSC/TRiP Functional Genomics Resources

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Protein Alignment Herc4 and herc5.4

DIOPT Version :9

Sequence 1:NP_001261249.1 Gene:Herc4 / 38151 FlyBaseID:FBgn0035207 Length:1062 Species:Drosophila melanogaster
Sequence 2:XP_005160166.1 Gene:herc5.4 / 100148091 ZFINID:ZDB-GENE-090311-7 Length:995 Species:Danio rerio


Alignment Length:1110 Identity:362/1110 - (32%)
Similarity:539/1110 - (48%) Gaps:182/1110 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 WGSTSHGQLGLGGIEDEQILTPS-QIPWTPDTAVQQVACGHRHTLFLTATGKVYACGSNDYSQLG 73
            ||  :..:.|.|.::.||:...: .|.:.|.:|||.::.| :..:.....|||.....::     
Zfish     5 WG--AQVREGFGLVKPEQVRHGNWGIKFCPSSAVQDISAG-KSCIGFIREGKVSVLRLHN----- 61

  Fly    74 HDLPTKRPRMSPFLLIPELQDYVIIQICCGSRHSLALSDWGQVLSWGDNDCGQLGHATDKEIVQL 138
            .|...|   :.|.    :||:..|..|.||...::.|:|.|:||            ..|:..|..
Zfish    62 EDADEK---LEPL----QLQNERIRSIVCGEAGAVLLADDGKVL------------IMDQSTVCR 107

  Fly   139 PKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGSNIYGQLGVNSPNDLTHCNYPLRLTTLLGI 203
            |  ::.|..:.|:|||||:.||:||::.|:|:.||.|.:||||:......|..  |..|.:|..|
Zfish   108 P--LKSLENRQVIQIACGDQHSMALSNDGQLFVWGENTHGQLGLRKEQAGTQS--PQHLQSLCEI 168

  Fly   204 PLAAIACGGNHSFLISKSGAVFGWGRNNCGQLGLNDETNRSYPTQLKTLRTLGVRFVACGDEFSV 268
            |:|.|:.||||||::|.||.|||||.|:.|||||.|..:|..||.:|:|.......::||.|.:.
Zfish   169 PVAQISAGGNHSFVLSLSGVVFGWGSNSAGQLGLGDTKDRFVPTIVKSLCGKKTVSISCGGEHTA 233

  Fly   269 FLTNEGGVFTCGAGAYGQLGHGFSSNEMLPRMVMELMGSTITQVACGNRHTLALVPSRGRVYAFG 333
            .|:..|.|||.|:|.:|||||....:|..||::.||.||.::||.||..|||....|...:|:||
Zfish   234 TLSKGGTVFTFGSGGFGQLGHNSLKDEHHPRLIAELWGSKVSQVTCGRHHTLVFEESSKLIYSFG 298

  Fly   334 LGSSGQLGTRSTKSLMLPQVVIGPWVSPSGSALLQSNDSQVSLVIRQIFSGGDQSIVTTTLFVDK 398
            .|..||||........:|..|:.|             .......:.::.:|...|.   .||. |
Zfish   299 CGMQGQLGNGEQVKQSVPLPVLLP-------------TECTEFTMEKLITGEHHSF---ALFF-K 346

  Fly   399 VPPEDFRNYNPKS----QILTLTAEVTKQCAQCKQGLQSD--MDLLSSIELIFRSQACWNGSFL- 456
            .|..:  :..|||    .||||...:..:...     :||  ..:.:.|..:|.|.|..||||| 
Zfish   347 NPGNE--SEKPKSGSNGGILTLNDRMIDRWVS-----ESDPWPTVKNEINTVFSSAASLNGSFLK 404

  Fly   457 LDHDRHFGCSVRNHGLDLKAAQLAFDNLRAVENESIRQVIWDNITKELVGSLVCSPADVESMRLY 521
            ...|.|:..||.:.|||....:.:|..|.|  ::|:...:...:.:.|:.||..:|..||::|||
Zfish   405 TSRDEHYQTSVEHCGLDFDLVKTSFAKLFA--SKSLISEVVKVVQQTLLPSLNPNPTGVEALRLY 467

  Fly   522 LLLPLYHEFVN--SKHYKSLQVPFANAIFKLAENPRKVLNKWLAQTPAEYFEHLVQNF------- 577
            ||||   |.:|  .|....|....|:.|.:|....||||..:.::.|.::||.|::.|       
Zfish   468 LLLP---ELINGLKKQRTKLIEALASKILELNSAARKVLEMYWSRLPDDWFERLIKLFHKESTDL 529

  Fly   578 ---------------LHVVIHIISFKMGLAAASPSAERRQQLLPYNTELEII------LKLMKTL 621
                           |..::.|:.....::.::........:...|..|:::      |..|:..
Zfish   530 IDQICDETDHQSTRHLKNILEILQMAYQISCSTDITHHDFIIHKINDLLDLLQTITADLLRMELY 594

  Fly   622 CQINNERHDRLNYQIFY---------WPDLSDYADVQQEYVKWIMADTARDFNICNYSFIFDQSA 677
            .|||.:.||.:..:.:|         :|..||:...|            |.||            
Zfish   595 MQINEDFHDMVKLEEYYFRTVKILVKFPFASDFITKQ------------RMFN------------ 635

  Fly   678 KTALLQADQALQMHSAMANAATMAF--SFFNYGMPISQFIVLNVTRENLVQDSLRELQHYSQSDL 740
               |||.:       ...|...:|.  ||.|         :|::.||:::.|:|:.|:..:.| .
Zfish   636 ---LLQEE-------CFRNVPNLAMGNSFSN---------LLHINRESVLTDTLQYLRQNTHS-F 680

  Fly   741 KKPLKIKFHGEEAEDAGGVRKEFFMLLLKDLL--DPKYGMFKEYEQSRLLWF-ADLTFETENMYF 802
            ..||::.|.||:..|..|:..|||.|:.|..:  |.|   ..|..:|.|:|| ...|...:|.|:
Zfish   681 MHPLQVAFIGEDGIDMRGLSAEFFSLISKSFIEWDKK---ILEVHESSLVWFNPHHTRGNKNFYY 742

  Fly   803 LIGVLCGLAIYNFTIINLPFPLALFKKLLGKPVDLSDLRQLSPPEANSMQSLLDYQGDDFKEVFD 867
            | ||:||:|:||...||:.||||||||||.:...|.||.:|||.||.|:::||:   :|.:||.:
Zfish   743 L-GVICGMALYNRHHINIDFPLALFKKLLQQKPSLDDLEELSPVEARSLKNLLE---EDEEEVVN 803

  Fly   868 LTFEISRDVFGEAETKC----LKPNGNEIAVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMK 928
            |.         ..:..|    |.|||::|.|...|||::||||||..|||||:..:..|.:||.|
Zfish   804 LQ---------HLDFTCKGQELVPNGSQIQVNKVNRQKYVDLYVDLEFNKSVKTQFEQFTRGFSK 859

  Fly   929 VCSGRVIHIFQPEELMAVVVGNEDYDWQALQDNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSF 993
            .|......:|.||||..::.|:..|:|:.||.:..| ||.::.|:.||.||.|..::||..||.|
Zfish   860 GCPLDAWTMFHPEELQELLHGSPQYNWKELQQSASY-EGCSASDELIKNFWTVFFELSEENKKKF 923

  Fly   994 LLFLTGSDRIPIQGM--KALKL--TIQPTPDERFLPVAHTCFNLLDLPRYKTKERLKYKLLQAIQ 1054
            |:||.|::|:|..|:  :|||:  |..|.||:. ||.|.|||..|.||:|.....|..||:.||.
Zfish   924 LMFLYGTERVPAGGLSKRALKISQTDCPDPDDH-LPEAQTCFERLVLPKYSDINTLHDKLIHAIN 987

  Fly  1055 QTQGF 1059
            ....|
Zfish   988 SCAVF 992

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Herc4NP_001261249.1 RCC1 6..55 CDD:278826 12/45 (27%)
RCC1 59..110 CDD:278826 12/50 (24%)
RCC1 114..163 CDD:278826 15/48 (31%)
RCC1 167..218 CDD:278826 23/50 (46%)
RCC1 221..270 CDD:278826 22/48 (46%)
RCC1 273..322 CDD:278826 25/48 (52%)
RCC1_2 309..339 CDD:290274 12/29 (41%)
RCC1 327..390 CDD:278826 13/62 (21%)
HECTc 715..1060 CDD:238033 144/356 (40%)
HECTc 739..1059 CDD:214523 136/330 (41%)
herc5.4XP_005160166.1 RCC1_2 117..146 CDD:290274 15/28 (54%)
RCC1 133..183 CDD:278826 23/51 (45%)
RCC1 186..235 CDD:278826 22/48 (46%)
RCC1 239..286 CDD:278826 24/46 (52%)
RCC1 294..343 CDD:278826 13/64 (20%)
HECTc 658..993 CDD:294058 144/354 (41%)
HECTc 682..992 CDD:214523 136/327 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG57432
OrthoDB 1 1.010 - - D1062377at2759
OrthoFinder 1 1.000 - - FOG0001110
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45622
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X678
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
87.890

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