Protein Alignment Herc4 and herc5.3

DIOPT Version :9

• Sequence 1: NP_001261249.1
• Gene: Herc4 / 38151
• FlyBaseID: FBgn0035207
• Length: 1062
• Species: Drosophila melanogaster
• Sequence 2: XP_021330683.1
• Gene: herc5.3 / 100073325
• ZFINID: ZDB-GENE-070615-14
• Length: 1002
• Species: Danio rerio
• Alignment Length: 1120
• Identity: 359/1120 - (32%)
• Similarity: 533/1120 - (47%)
• Gaps: 195/1120 - (17%)

  Fly    10 WGSTSHGQLGLGGIEDEQI---------LTPSQIPWTPDTAVQQVACGHRHTLFL-TATGKVYAC 64
            ||  :..:.|.|.::.||:         :.||..  ...|.||.::.|..:..|: ..|..:...
Zfish     5 WG--AQVREGFGLVKPEQVIHGNWGIKSICPSSA--ACGTLVQDISTGKSYVGFIREGTAWILRL 65

  Fly    65 GSNDYSQLGHDLPTKRPRMSPFLLIPELQDYVIIQICCGSRHSLALSDWGQVLSWGDNDCGQLGH 129
            .:.|..:          ::.|.    :||:..|..|.||...::.|:|.|:||
Zfish    66 HNEDADE----------KLEPL----QLQNERIRSIVCGEAGAVLLADDGKVL------------ 104

  Fly   130 ATDKEIVQLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGSNIYGQLGVNSPNDLTHCNYP 194
            ..|:..|..|  ::.|..:.|:|||||:.||:|||:.|:|:.||.|..||||:......|..  |
Zfish   105 VMDQSTVCRP--LKGLENRQVIQIACGDQHSMALTNDGQLFVWGENALGQLGLRKEQAGTQS--P 165

  Fly   195 LRLTTLLGIPLAAIACGGNHSFLISKSGAVFGWGRNNCGQLGLNDETNRSYPTQLKTLRTLGVRF 259
            ..|.:|.|||:|.|:.||||||::|.||.|||||.|:.|||||.|.|:|..||.:|:|.......
Zfish   166 QHLQSLCGIPVAQISAGGNHSFVLSLSGVVFGWGSNSAGQLGLGDTTDRFIPTIVKSLSGKKTVS 230

  Fly   260 VACGDEFSVFLTNEGGVFTCGAGAYGQLGHGFSSNEMLPRMVMELMGSTITQVACGNRHTLALVP 324
            ::||.|.:..|:..|.|||.|:|.:|||||....:|..||:|.||.||.::||.||..|||....
Zfish   231 ISCGGEHTATLSKGGTVFTFGSGGFGQLGHNSLKDEHHPRLVAELWGSKVSQVTCGRHHTLVFED 295

  Fly   325 SRGRVYAFGLGSSGQLGTRSTKSLMLPQVVIGPWVSPSGSALLQSNDSQVSLVIRQIFSGGDQSI 389
            |..::|:||.|..||||........:|..|:.|             .......:.::.:|.:.|.
Zfish   296 SSNQIYSFGCGMQGQLGNGEQVKQSVPLPVLLP-------------TECTEFTMEKLIAGENHSF 347

  Fly   390 VTTTLFVDKVPPEDFRNYNPKS----QILTLTAEVTKQCAQCKQGLQSD--MDLLSSIELIFRSQ 448
               .||. |.|..:  :..|||    .||||...:..:...     :||  ..:.:.|..:|.|.
Zfish   348 ---ALFF-KSPGNE--SEKPKSGSNGGILTLNDRIIDRWVS-----ESDPWPTIKNEINTVFSSA 401

  Fly   449 ACWNGSFL-LDHDRHFGCSVRNHGLDLKAAQLAFDNLRAVENESIRQVIWDNITKELVGSLVCSP 512
            |..||||| ...|.|:..||...|||....:.:|..|..  ::|:...:...:.:.|:.||..:|
Zfish   402 ASLNGSFLKTSRDEHYQTSVERCGLDFDLVKTSFAKLST--SKSLISEVVKVVQQTLLPSLNPNP 464

  Fly   513 ADVESMRLYLLLPLYHEFVN--SKHYKSLQVPFANAIFKLAENPRKVLNKWLAQTPAEYFEHLVQ 575
            ...|::|||||||   |.:|  .|....|....|..|.:|....||||..:.::.|.::||.|::
Zfish   465 TGEEALRLYLLLP---ELINGLKKQRTKLIEALAFKILELCPAARKVLEMYWSRLPDDWFEALIK 526

  Fly   576 NFLHVVIHIISFKMGLAAASPSAERRQQLLPYNTE----------LEIILKLMKTLCQINNERHD 630
            .|     |           ..|||..:|:....|:          |||:....:..|..|...||
Zfish   527 LF-----H-----------KESAELIKQISRGETDDQSTRHLKNFLEILQMAYQICCSTNITNHD 575

  Fly   631 RLNYQIFYWPDLSDY---ADVQQEYVKWIMADTARDFNICNYSFIFDQSAKTALLQADQALQMHS 692
                  |..|:::|.   .|.....|.|:.:....:..:.|...:.|...|||.:
Zfish   576 ------FIIPEVNDLLETLDATSAEVLWMASRLPINEELHNRMKLEDYYFKTAEI---------- 624

  Fly   693 AMANAATMAFSFFNYGMPISQFI----------------------------VLNVTRENLVQDSL 729
                  .:.|.|      :|.|:                            :|::.||:::.|:|
Zfish   625 ------LVKFPF------VSDFLTKKSMFILLQEQCIRSLLDLLVVHLNGNLLHINRESVLTDTL 677

  Fly   730 RELQHYSQSDLKKPLKIKFHGEEAEDAGGVRKEFFMLLLKDLL--DPKYGMFKEYEQSRLLWFAD 792
            :.|:.::.| ...||::.|.||:..|...:..|||.|:.|..:  |.|   ..|..:|.|:||..
Zfish   678 QYLRPFTYS-FMHPLQVAFIGEDEIDEKVISAEFFSLISKSFIEWDKK---ILEVHESSLVWFNP 738

  Fly   793 LTFETENMYFLIGVLCGLAIYNFTIINLPFPLALFKKLLGKPVDLSDLRQLSPPEANSMQSLLDY 857
            ...:....::.:||:||:|:||...||:.||||||||||.:...|.||.:|||.||.|:::||:
Zfish   739 HHTQDHRDFYYLGVICGMALYNRHHINIDFPLALFKKLLQQKPSLDDLEELSPVEARSLKNLLE- 802

  Fly   858 QGDDFKEVFDLTFEISRDVFGEAETKC----LKPNGNEIAVTLENRQEFVDLYVDFVFNKSVELH 918
              :|.:||.||.         ..:..|    |.|||::|.|...|||::|||||||||||||:..
Zfish   803 --EDEEEVVDLQ---------HLDFTCKGQELVPNGSQIQVNKVNRQKYVDLYVDFVFNKSVKTQ 856

  Fly   919 YNAFHKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQALQDNCEYREGYTSVDDTIKWFWEVIH 983
            :..|.:||.:.|......:|.||||..::.|:..|:|..||.:..| ||.::.|:.||.||.|..
Zfish   857 FEQFTEGFSEGCPLDAWTMFHPEELQELLHGSPQYNWNELQQSASY-EGCSASDELIKNFWTVFF 920

  Fly   984 DMSEAEKKSFLLFLTGSDRIPIQGM--KALKL--TIQPTPDERFLPVAHTCFNLLDLPRYKTKER 1044
            ::||..||.||:||.|::|:|..|.  :|||:  |..|.||:. ||.|.|||..|.||:|.....
Zfish   921 ELSEENKKKFLMFLYGTERVPAGGFSKRALKISQTDCPDPDDH-LPEAQTCFERLVLPKYSDINT 984

  Fly  1045 LKYKLLQAIQQTQGF 1059
            |:.||:.|:.....|
Zfish   985 LRDKLIHAVNSCAVF 999

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826	12/53 (23%)
		RCC1	59..110	CDD:278826	8/50 (16%)
		RCC1	114..163	CDD:278826	15/48 (31%)
		RCC1	167..218	CDD:278826	24/50 (48%)
		RCC1	221..270	CDD:278826	23/48 (48%)
		RCC1	273..322	CDD:278826	26/48 (54%)
		RCC1_2	309..339	CDD:290274	12/29 (41%)
		RCC1	327..390	CDD:278826	13/62 (21%)
		HECTc	715..1060	CDD:238033	140/383 (37%)
		HECTc	739..1059	CDD:214523	132/329 (40%)
herc5.3	XP_021330683.1	RCC1	<74..349	CDD:332518	116/310 (37%)
		HECTc	665..1000	CDD:331829	140/353 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57432
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	1	1.000	-	-		FOG0001110
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45622
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X678
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.030