DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Herc4 and herc4

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	XP_031760534.1	Gene:	herc4 / 100036667	XenbaseID:	XB-GENE-962981	Length:	1057	Species:	Xenopus tropicalis

Alignment Length:	1078	Identity:	485/1078 - (44%)
Similarity:	676/1078 - (62%)	Gaps:	43/1078 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LYCWGSTSHGQLGLGGIEDEQILTPSQIPWTPDTAVQQVACGHRHTLFLTATGKVYACGSNDYSQ 71
            :.|||:||.||||||||::|.:|.|.:..:..:..|:.|.||.|||:|:...|.||.||.||..|
Frog     1 MLCWGNTSFGQLGLGGIDEEVVLEPRRCDFFINKNVRDVGCGSRHTVFVLDDGTVYTCGCNDLGQ 65

  Fly    72 LGHDLPTKRPRMSPFLLIPELQDYVIIQICCGSRHSLALSDWGQVLSWGDNDCGQLGHATDKEIV 136
            ||||...::|..     :..|...:|:.:.||..|:|||:|.|||.|||....||:|.:|.:|.:
Frog    66 LGHDKSRRKPEQ-----VGALDAQIIVAVSCGEAHTLALNDKGQVFSWGHAVYGQIGLSTAEEYI 125

  Fly   137 QLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGSNIYGQLGVNSPNDLTHCNYPLRLTTLL 201
            ::|:.::.|....:||:|||::|||||:...:::|||.|.|||||:..  ::.....|..:.:|.
Frog   126 RVPRNIKSLSDVQIVQVACGHHHSLALSKDSDIFSWGQNQYGQLGLGL--EIKKECAPRHIKSLS 188

  Fly   202 GIPLAAIACGGNHSFLISKSGAVFGWGRNNCGQLGLNDETNRSYPTQLKTLRTLGVRFVACGDEF 266
            |||.|.||.||.|||.::.|||:||||||..|||||.|||:|:.|..||:||:..:..:.||::.
Frog   189 GIPFAHIAAGGGHSFALTISGAIFGWGRNKFGQLGLTDETDRNVPALLKSLRSQKIIHICCGEDH 253

  Fly   267 SVFLTNEGGVFTCGAGAYGQLGHGFSSNEMLPRMVMELMGSTITQVACGNRHTLALVPSRGRVYA 331
            :..||.||||||.|||.||||||..:::|:.||.|.|||||.:||:|||.:||||.|||.||:|:
Frog   254 TAALTKEGGVFTFGAGGYGQLGHNSTNHEVNPRKVFELMGSIVTQIACGRQHTLAFVPSSGRIYS 318

  Fly   332 FGLGSSGQLGTRSTKSLMLPQVVIGPWVSPSGSA--LLQSNDSQVSLVIRQIFSGGDQSIVTTTL 394
            ||||.:|||||.||.:...|..|.|.|::.....  |.::|.   ...:::|:||||||......
Frog   319 FGLGGNGQLGTGSTINRKSPFTVKGNWLTYEDYVRHLPEANG---CYCLKRIYSGGDQSFAHYIT 380

  Fly   395 FVDKVPPEDFRNYNPKSQILTLTAEVTKQCAQCKQGLQSDMDLLSSIELIFRSQACWNGSFLL-D 458
            ..:..||:|||..|...:|.||...|.::......| :..:::::.|:.:|.|.||.|||||: .
Frog   381 IQNCHPPDDFRRCNCSRKIRTLDEGVIQRWLNYSLG-RLPLEIVNEIDKVFSSAACLNGSFLVTS 444

  Fly   459 HDRHFGCSVRNHGLDLKAAQLAFDNLRAVENESIRQVIWDNITKELVGSLVCSPADVESMRLYLL 523
            ::.|:..|.:..|:|:..|:|....|.......|.|.:..::.|.|:..|..||.|:|.:||||:
Frog   445 NNDHYMTSSKFSGVDMNVARLLLHKLMDPSQPQIAQQVAASLEKNLIPRLTSSPPDIECLRLYLI 509

  Fly   524 LPLYHEFVNSKHYKSLQVPFANAIFKLAENPRKVLNKWLAQTPAEYFEHLVQNFLHVVIHIISF- 587
            ||......::.:..||.:||..||..|.:.|.|||..|.:......|..:||.:..||:|::..
Frog   510 LPECPPMADANNLTSLAIPFGTAIVNLEKAPLKVLENWWSLLEPPLFLKVVQLYKDVVVHLLKLS 574

  Fly   588 KMGLAAASPSAERRQQLLPYNTELEIILKLMKTLCQINNERHDRLNYQIFYWPDLSDYADVQQEY 652
            |.|:    |..|||   |.|.. |...|::::.|.::|.:....:.|..||..::.|:.|:|.:|
Frog   575 KNGI----PLTERR---LFYRF-LNTALRVLEILHRVNEKAAQIIPYDKFYIHEVQDFVDIQNDY 631

  Fly   653 VKWIMAD-TARDFN------------ICNYSFIFDQSAKTALLQADQALQMHSAMANAATMAFSF 704
            :.||... :..|.|            ||.|.|:||..|||.|||.|..:||..|:.||...  :.
Frog   632 INWIKQQASGMDVNHGLYEVADPPVTICTYPFVFDAQAKTTLLQTDAVIQMQMAVDNAHRQ--NN 694

  Fly   705 FNYGMPISQFI----VLNVTRENLVQDSLRELQHYSQSDLKKPLKIKFHGEEAEDAGGVRKEFFM 765
            .::..|.::.:    :|.|.|:|:|.|::..|:.....|.|||:::.|.||||.||||||||||:
Frog   695 LSWLFPATESVDPCLILVVRRDNIVGDAMEVLRKTKNIDYKKPMRVIFFGEEAIDAGGVRKEFFL 759

  Fly   766 LLLKDLLDPKYGMFKEYEQSRLLWFADLTFETENMYFLIGVLCGLAIYNFTIINLPFPLALFKKL 830
            |::::|||||||||:.||:|||:||:|.|||..:::.||||:|||||||||||.|.|||||:|||
Frog   760 LIMRELLDPKYGMFRYYEESRLIWFSDKTFEDSDLFHLIGVVCGLAIYNFTIIELHFPLALYKKL 824

  Fly   831 LGKPVDLSDLRQLSPPEANSMQSLLDYQGDDFKEVFDLTFEISRDVFGEAETKCLKPNGNEIAVT 895
            |.|...|.||::|.|....|||.||||..||.:|.|.|.|.|:.:.||..|.:.|.|||.||.|.
Frog   825 LKKKPSLEDLKELMPIIGRSMQQLLDYTEDDIEETFCLNFTITVENFGTTEVRELIPNGAEIPVN 889

  Fly   896 LENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQALQD 960
            .:|||:|||.|||::||:||...::||..||.|||..:|:.:|||.||.|:|:||..|||:.|:.
Frog   890 RKNRQDFVDAYVDYIFNQSVASLFSAFSAGFHKVCGSKVLELFQPNELQAMVIGNTAYDWKELEK 954

  Fly   961 NCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKALKLTIQPT-PDERFL 1024
            :.||:..|.:...|||.|||:.|.:...:||.|||||||||||||.|||:|||.|||| ..|:||
Frog   955 STEYKGEYWADHPTIKMFWEIFHALPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQPTGGGEQFL 1019

  Fly  1025 PVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGFSLV 1062
            |||||||||||||:|..||.|:.||:|||...:|||||
Frog  1020 PVAHTCFNLLDLPKYSKKETLRSKLIQAIDHYEGFSLV 1057

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826	23/47 (49%)
		RCC1	59..110	CDD:278826	19/50 (38%)
		RCC1	114..163	CDD:278826	21/48 (44%)
		RCC1	167..218	CDD:278826	22/50 (44%)
		RCC1	221..270	CDD:278826	25/48 (52%)
		RCC1	273..322	CDD:278826	32/48 (67%)
		RCC1_2	309..339	CDD:290274	19/29 (66%)
		RCC1	327..390	CDD:278826	27/64 (42%)
		HECTc	715..1060	CDD:238033	197/349 (56%)
		HECTc	739..1059	CDD:214523	189/320 (59%)
herc4	XP_031760534.1	ATS1	2..353	CDD:227511	172/357 (48%)
herc4	XP_031760534.1	HECTc	709..1055	CDD:238033	197/345 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	352	1.000	Domainoid score	I1004
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H56715
Inparanoid	1	1.050	901	1.000	Inparanoid score	I375
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	1	1.000	-	-		FOG0001110
OrthoInspector	1	1.000	-	-		otm48443
Panther	1	1.100	-	-	O	PTHR45622
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X678
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160