DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Herc4 and herc3

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_001139096.1	Gene:	herc3 / 100003587	ZFINID:	ZDB-GENE-090313-139	Length:	1046	Species:	Danio rerio

Alignment Length:	1081	Identity:	463/1081 - (42%)
Similarity:	655/1081 - (60%)	Gaps:	61/1081 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LYCWGSTSHGQLGLGGIEDEQILTPSQIPWTPDTAVQQVACGHRHTLFLTATGKVYACGSNDYSQ 71
            :.||||:..||||:|..| ..:..|..........:::||||::|:|||...|.||.||||...|
Zfish     2 MLCWGSSGAGQLGIGASE-ASVFEPRSCCVFDGRGLKEVACGNQHSLFLLHDGSVYTCGSNSCGQ 65

  Fly    72 LGHDLPTKRPRMSPFLLIPELQDYVIIQICCGSRHSLALSDWGQVLSWGDNDCGQLGHATDKEIV 136
            ||||....||.     |:..|....|..:.||..||||:::.|||.:||..|.||||..|.:|.|
Zfish    66 LGHDKGGSRPE-----LVGALDAQKISGVSCGQAHSLAVNEQGQVFAWGAGDGGQLGLGTAEEAV 125

  Fly   137 QLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGSNIYGQLGV--NSPNDLTHCNYPLRLTT 199
            ::|:::::|....:.|:.|||:|.:||:..|:|:.||.|..||||:  ..|:.|:    |..|.:
Zfish   126 RVPRLIKKLCEHRISQVMCGNHHCIALSKDGQLFVWGENSSGQLGLGKGEPSTLS----PQPLKS 186

  Fly   200 LLGIPLAAIACGGNHSFLISKSGAVFGWGRNNCGQLGLNDETNRSYPTQLKTLRTLGVRFVACGD 264
            |.||||..|:.||:|||.:|.||||||||:|:.||||||||.:|:.|..:|.||:..|.:::||:
Zfish   187 LCGIPLTQISAGGDHSFALSFSGAVFGWGKNSAGQLGLNDEQDRAVPCHIKFLRSQKVVYISCGE 251

  Fly   265 EFSVFLTNEGGVFTCGAGAYGQLGHGFSSNEMLPRMVMELMGSTITQVACGNRHTLALVPSRGRV 329
            |.:..||.|||:||.|.|:.|||||..:.||.|||.||||||:.::|:|||..||||.|||.|.:
Zfish   252 EHTAALTKEGGLFTFGNGSKGQLGHDSTRNEPLPRRVMELMGTEVSQIACGRNHTLAFVPSTGLI 316

  Fly   330 YAFGLGSSGQLGTRSTKSLMLPQVVIGPWVSP--SGSALLQSNDSQVSLVIRQIFSGGDQSIVTT 392
            ||||..:.|||||....|...|..|..  :.|  .|:|..::.    ...|.:|.||||.:.:..
Zfish   317 YAFGCNTQGQLGTGIRGSAKSPVPVSN--IQPLCIGNAYTRTE----HCTIAKIHSGGDHNFLLL 375

  Fly   393 TLFVDKVPPEDFRNYNPKSQILTLTAEVTKQCAQCKQGLQSDMDLLSSIELIFRSQACWNGSFL- 456
            :.......|:|||..|....|..:.:| :....:.|....||..:.:.|.|:..|.||||.|||
Zfish   376 STVEGLSCPDDFRILNTTKSIALINSE-SLDSWRMKLHDNSDSSITNDIILLLSSTACWNASFLD 439

  Fly   457 LDHDRHFGCSVRNHGLDLKAAQLAFDNLRAVENESIRQVIWDNITKELVGSLVCSPADVESMRLY 521
            ...|.||..:.:..|:|..|.:|.|:.|.......:.:.|..:....|:..|.|||.|||:||:|
Zfish   440 QSDDGHFKTNPKVPGIDFNAVRLLFETLMKPAFARLLEQITKSFESLLIPQLPCSPPDVEAMRIY 504

  Fly   522 LLLPLYHEFVNSKHYKSLQVPFANAIFKLAENPRKVLNKWLAQTPAEYFEHLVQNFLHVVIHIIS 586
            |:|.....|.:||:|.:|.:|.|.||.:|..||.|||:.|.:......|..||:.:..:|:.:::
Zfish   505 LILSECPAFQDSKNYITLTIPLAMAILRLDANPSKVLDNWWSLMDCTVFTRLVEMYKSIVVFLLT 569

  Fly   587 FKMGLAAASPSAERRQQLLPYNTE--LEIILKLMKTLCQINNERHDRLNYQIFYWPDLSDYADVQ 649
            ....|            |:|...|  ....|:|::.|.::|.:.| |:.|..||.||::...|:|
Zfish   570 GGKAL------------LMPVFLESYTSAALRLLEKLHKVNLKAH-RVEYNHFYIPDIATLVDIQ 621

  Fly   650 QEYVKWIM--ADTARDF-------NICNYSFIFDQSAKTALLQADQALQMHSAMANAATMAFSFF 705
            ::|:||.:  ||....:       .:|.|.||.:..|||.:||.|..|||..|::.|     :..
Zfish   622 EDYLKWFLRKADIKMRYPPVQGSVTLCAYPFILNAQAKTTVLQTDAELQMQMAVSGA-----NLH 681

  Fly   706 NYGMPISQ--------FIVLNVTRENLVQDSLRELQHYSQSDLKKPLKIKFHGEEAEDAGGVRKE 762
            |..|.::.        |:||:|.|.:||.|:||||..|:..|||||||:.|.||||.|||||.||
Zfish   682 NVFMLLTMEPLLARNPFLVLHVRRNHLVSDALRELTIYNDVDLKKPLKVIFDGEEAVDAGGVTKE 746

  Fly   763 FFMLLLKDLLDPKYGMFKEYEQSRLLWFADLTFETENMYFLIGVLCGLAIYNFTIINLPFPLALF 827
            ||:||||:|::|.||||.:|.:|.||||:|..|...|.:.|||::|||||||.|:::|.|||.|:
Zfish   747 FFLLLLKELMNPIYGMFTQYSESNLLWFSDKCFVEHNWFHLIGIICGLAIYNSTVVDLHFPLVLY 811

  Fly   828 KKLLGKPVDLSDLRQLSPPEANSMQSLLDYQGDDFKEVFDLTFEISRDVFGEAETKCLKPNGNEI 892
            ||||.....|.||::|||.|..|:|.||:::| |.:|.|.|.|.|:|:.:|..|.|.|...|..|
Zfish   812 KKLLEISPTLDDLKELSPTEGRSLQQLLEFEG-DVEETFCLNFAITREYYGITEVKELVQGGKTI 875

  Fly   893 AVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQA 957
            ||...||:|||..|:.:||:.:|:..|:||..||:|||.|.::.:|||.||||:||||.:|:|:.
Zfish   876 AVDKTNRKEFVQAYLQYVFSDAVQEQYSAFSSGFLKVCGGEILSLFQPSELMAMVVGNNNYNWEE 940

  Fly   958 LQDNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKALKLTIQPT-PDE 1021
            ::.|..|:..:::...|:|.||||.|:.|..:||.|||||||||||||.||.:|::.||.| .:|
Zfish   941 MEKNASYKGEFSATHPTVKMFWEVFHEFSLEKKKQFLLFLTGSDRIPIHGMASLRIVIQSTAAEE 1005

  Fly  1022 RFLPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGFSLV 1062
            .:|||||||:|:||:|.|:|||.|:.:|.||::|.:|||||
Zfish  1006 HYLPVAHTCYNMLDMPCYQTKETLRQRLTQAVEQYEGFSLV 1046

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826	17/47 (36%)
		RCC1	59..110	CDD:278826	22/50 (44%)
		RCC1	114..163	CDD:278826	20/48 (42%)
		RCC1	167..218	CDD:278826	24/52 (46%)
		RCC1	221..270	CDD:278826	26/48 (54%)
		RCC1	273..322	CDD:278826	30/48 (63%)
		RCC1_2	309..339	CDD:290274	16/29 (55%)
		RCC1	327..390	CDD:278826	22/64 (34%)
		HECTc	715..1060	CDD:238033	183/345 (53%)
		HECTc	739..1059	CDD:214523	170/320 (53%)
herc3	NP_001139096.1	RCC1	4..49	CDD:278826	17/45 (38%)
		RCC1_2	37..65	CDD:290274	15/27 (56%)
		RCC1	52..99	CDD:278826	22/51 (43%)
		RCC1	103..152	CDD:278826	20/48 (42%)
		RCC1	155..205	CDD:278826	24/53 (45%)
		RCC1	208..257	CDD:278826	26/48 (54%)
		RCC1	260..308	CDD:278826	29/47 (62%)
		RCC1	314..374	CDD:278826	22/65 (34%)
		HECTc	699..1044	CDD:238033	183/345 (53%)
		HECTc	723..1043	CDD:214523	170/320 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	343	1.000	Domainoid score	I1038
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	900	1.000	Inparanoid score	I366
OMA	1	1.010	-	-		QHG57432
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	1	1.000	-	-		FOG0001110
OrthoInspector	1	1.000	-	-		otm25593
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45622
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R774
SonicParanoid	1	1.000	-	-		X678
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.970