Protein Alignment Herc4 and herc3

DIOPT Version :10

• Sequence 1: NP_001261249.1
• Gene: Herc4 / 38151
• FlyBaseID: FBgn0035207
• Length: 1062
• Species: Drosophila melanogaster
• Sequence 2: NP_001139096.1
• Gene: herc3 / 100003587
• ZFINID: ZDB-GENE-090313-139
• Length: 1046
• Species: Danio rerio
• Alignment Length: 1081
• Identity: 463/1081 - (42%)
• Similarity: 656/1081 - (60%)
• Gaps: 61/1081 - (5%)

  Fly     7 LYCWGSTSHGQLGLGGIEDEQILTPSQIPWTPDTAVQQVACGHRHTLFLTATGKVYACGSNDYSQ 71
            :.||||:..||||:|..| ..:..|..........:::||||::|:|||...|.||.||||...|
Zfish     2 MLCWGSSGAGQLGIGASE-ASVFEPRSCCVFDGRGLKEVACGNQHSLFLLHDGSVYTCGSNSCGQ 65

  Fly    72 LGHDLPTKRPRMSPFLLIPELQDYVIIQICCGSRHSLALSDWGQVLSWGDNDCGQLGHATDKEIV 136
            ||||....||.     |:..|....|..:.||..||||:::.|||.:||..|.||||..|.:|.|
Zfish    66 LGHDKGGSRPE-----LVGALDAQKISGVSCGQAHSLAVNEQGQVFAWGAGDGGQLGLGTAEEAV 125

  Fly   137 QLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGSNIYGQLGV--NSPNDLTHCNYPLRLTT 199
            ::|:::::|....:.|:.|||:|.:||:..|:|:.||.|..||||:  ..|:.|:    |..|.:
Zfish   126 RVPRLIKKLCEHRISQVMCGNHHCIALSKDGQLFVWGENSSGQLGLGKGEPSTLS----PQPLKS 186

  Fly   200 LLGIPLAAIACGGNHSFLISKSGAVFGWGRNNCGQLGLNDETNRSYPTQLKTLRTLGVRFVACGD 264
            |.||||..|:.||:|||.:|.||||||||:|:.||||||||.:|:.|..:|.||:..|.:::||:
Zfish   187 LCGIPLTQISAGGDHSFALSFSGAVFGWGKNSAGQLGLNDEQDRAVPCHIKFLRSQKVVYISCGE 251

  Fly   265 EFSVFLTNEGGVFTCGAGAYGQLGHGFSSNEMLPRMVMELMGSTITQVACGNRHTLALVPSRGRV 329
            |.:..||.|||:||.|.|:.|||||..:.||.|||.||||||:.::|:|||..||||.|||.|.:
Zfish   252 EHTAALTKEGGLFTFGNGSKGQLGHDSTRNEPLPRRVMELMGTEVSQIACGRNHTLAFVPSTGLI 316

  Fly   330 YAFGLGSSGQLGT--RSTKSLMLPQVVIGPWVSPSGSALLQSNDSQVSLVIRQIFSGGDQSIVTT 392
            ||||..:.|||||  |.:....:|...|.|..  .|:|..::.    ...|.:|.||||.:.:..
Zfish   317 YAFGCNTQGQLGTGIRGSAKSPVPVSNIQPLC--IGNAYTRTE----HCTIAKIHSGGDHNFLLL 375

  Fly   393 TLFVDKVPPEDFRNYNPKSQILTLTAEVTKQCAQCKQGLQSDMDLLSSIELIFRSQACWNGSFL- 456
            :.......|:|||..|....|..:.:| :....:.|....||..:.:.|.|:..|.||||.|||
Zfish   376 STVEGLSCPDDFRILNTTKSIALINSE-SLDSWRMKLHDNSDSSITNDIILLLSSTACWNASFLD 439

  Fly   457 LDHDRHFGCSVRNHGLDLKAAQLAFDNLRAVENESIRQVIWDNITKELVGSLVCSPADVESMRLY 521
            ...|.||..:.:..|:|..|.:|.|:.|.......:.:.|..:....|:..|.|||.|||:||:|
Zfish   440 QSDDGHFKTNPKVPGIDFNAVRLLFETLMKPAFARLLEQITKSFESLLIPQLPCSPPDVEAMRIY 504

  Fly   522 LLLPLYHEFVNSKHYKSLQVPFANAIFKLAENPRKVLNKWLAQTPAEYFEHLVQNFLHVVIHIIS 586
            |:|.....|.:||:|.:|.:|.|.||.:|..||.|||:.|.:......|..||:.:..:|:.:::
Zfish   505 LILSECPAFQDSKNYITLTIPLAMAILRLDANPSKVLDNWWSLMDCTVFTRLVEMYKSIVVFLLT 569

  Fly   587 FKMGLAAASPSAERRQQLLPYNTE--LEIILKLMKTLCQINNERHDRLNYQIFYWPDLSDYADVQ 649
            ....|            |:|...|  ....|:|::.|.::|.:.| |:.|..||.||::...|:|
Zfish   570 GGKAL------------LMPVFLESYTSAALRLLEKLHKVNLKAH-RVEYNHFYIPDIATLVDIQ 621

  Fly   650 QEYVKWIM--ADTARDF-------NICNYSFIFDQSAKTALLQADQALQMHSAMANAATMAFSFF 705
            ::|:||.:  ||....:       .:|.|.||.:..|||.:||.|..|||..|::.|     :..
Zfish   622 EDYLKWFLRKADIKMRYPPVQGSVTLCAYPFILNAQAKTTVLQTDAELQMQMAVSGA-----NLH 681

  Fly   706 NYGMPISQ--------FIVLNVTRENLVQDSLRELQHYSQSDLKKPLKIKFHGEEAEDAGGVRKE 762
            |..|.::.        |:||:|.|.:||.|:||||..|:..|||||||:.|.||||.|||||.||
Zfish   682 NVFMLLTMEPLLARNPFLVLHVRRNHLVSDALRELTIYNDVDLKKPLKVIFDGEEAVDAGGVTKE 746

  Fly   763 FFMLLLKDLLDPKYGMFKEYEQSRLLWFADLTFETENMYFLIGVLCGLAIYNFTIINLPFPLALF 827
            ||:||||:|::|.||||.:|.:|.||||:|..|...|.:.|||::|||||||.|:::|.|||.|:
Zfish   747 FFLLLLKELMNPIYGMFTQYSESNLLWFSDKCFVEHNWFHLIGIICGLAIYNSTVVDLHFPLVLY 811

  Fly   828 KKLLGKPVDLSDLRQLSPPEANSMQSLLDYQGDDFKEVFDLTFEISRDVFGEAETKCLKPNGNEI 892
            ||||.....|.||::|||.|..|:|.||:::| |.:|.|.|.|.|:|:.:|..|.|.|...|..|
Zfish   812 KKLLEISPTLDDLKELSPTEGRSLQQLLEFEG-DVEETFCLNFAITREYYGITEVKELVQGGKTI 875

  Fly   893 AVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQA 957
            ||...||:|||..|:.:||:.:|:..|:||..||:|||.|.::.:|||.||||:||||.:|:|:.
Zfish   876 AVDKTNRKEFVQAYLQYVFSDAVQEQYSAFSSGFLKVCGGEILSLFQPSELMAMVVGNNNYNWEE 940

  Fly   958 LQDNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKALKLTIQPT-PDE 1021
            ::.|..|:..:::...|:|.||||.|:.|..:||.|||||||||||||.||.:|::.||.| .:|
Zfish   941 MEKNASYKGEFSATHPTVKMFWEVFHEFSLEKKKQFLLFLTGSDRIPIHGMASLRIVIQSTAAEE 1005

  Fly  1022 RFLPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGFSLV 1062
            .:|||||||:|:||:|.|:|||.|:.:|.||::|.:|||||
Zfish  1006 HYLPVAHTCYNMLDMPCYQTKETLRQRLTQAVEQYEGFSLV 1046

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	ATS1	7..352	CDD:444065	162/348 (47%)
		RCC1	327..390	CDD:395335	22/64 (34%)
		HECTc	715..1060	CDD:238033	183/345 (53%)
herc3	NP_001139096.1	ATS1	4..339	CDD:444065	162/344 (47%)
		RCC1	314..374	CDD:395335	22/65 (34%)
		HECTc	699..1044	CDD:238033	183/345 (53%)