DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ctr9 and ELF8

DIOPT Version :9

Sequence 1:	NP_788448.1	Gene:	Ctr9 / 38149	FlyBaseID:	FBgn0035205	Length:	1150	Species:	Drosophila melanogaster
Sequence 2:	NP_178674.7	Gene:	ELF8 / 815177	AraportID:	AT2G06210	Length:	1091	Species:	Arabidopsis thaliana

Alignment Length:	1143	Identity:	349/1143 - (30%)
Similarity:	566/1143 - (49%)	Gaps:	139/1143 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IEIPLQDTDEVIEVDPDQLP-DCPEVLSILKQERAPLHVWVNVALAYYKQKKTEDFVTLLEESRS 68
            :.||:|:::|.:.|..|||| |..::|.|||.|:|||.:|:.:|..|:||.|.|.|..:|||..|
plant     4 VYIPVQNSEEEVRVVLDQLPRDASDILDILKAEQAPLDLWLIIAREYFKQGKIEQFRQILEEGSS 68

  Fly    69 DDATKEYRDSDKDLMRALDMLAAHYVQEAYREKSKDKKRELFMKATNLYTSADKIIMYDQSHLLG 133
            .|..:.|.|...:.:..|:.|.|:|......|....:|.|.|:.||..|..|.:|.|::.|..:|
plant    69 SDIDEYYADVKYERIAILNALGAYYSYLGKTETKNREKEEQFISATRYYNKASRIDMHEPSTWVG 133

  Fly   134 RAYFCLLEGDKMDQADAQFNFVLNQSPSNIPSLLGKACIAFNRKDYRGAMAFYKKALRTNPNCPA 198
            :....|.:|: :|.|...|..||:.:|.|:|:|||:|.:.|||..:..::..||:||:..|.|||
plant   134 KGQLLLAKGE-IDNALQAFKIVLDTAPDNVPALLGQASVEFNRGRFSESLQLYKRALQVFPGCPA 197

  Fly   199 NVRIGMAHCFLKMGNPEKAKLAFERALQLDQQCVGALIGLAVLKLNQLEPESNKLGVQMLSKAYT 263
            .||:|:. |..|:|..:||:.||:|.||||...|.||:.|.::.|...:....:.|:..:.:|:.
plant   198 AVRLGIGXCRYKLGQLDKARQAFDRVLQLDPDNVEALVALGIMDLQANDSIGMRKGMDRMQQAFE 262

  Fly   264 IDNANPMVLNHLANHFFFKKDYQKVHHLALHAFHNTENEAMRAESCYQLARSFHAQSDYDQAFQY 328
            |.......||:|||||||...:..|..|...|...|.:...::.|.|.||||:|::.|:::|..|
plant   263 IYPYCASALNYLANHFFFTGQHFLVEQLTETALAVTTHGPTKSHSFYNLARSYHSKGDFEKAGMY 327

  Fly   329 Y---YQSTQIAPANFVLPHYGLGQMYIYRGDTENAAQCFEKVLKIQPGNYETMKILGSLYAHSNS 390
            |   .:.|...|..||.|::||||:.:..|:.:.:...|||||::.|.|.||:|.||.||.....
plant   328 YMAAIKETNNNPHEFVFPYFGLGQVQLKLGELKGSVFNFEKVLEVYPDNCETLKALGHLYTQLGQ 392

  Fly   391 QTKRDMAKTHLKKVTEQFPEDIEAWIELAQILEQNDLQASLSAYGTASSILRDKAKYEIPAEIQN 455
            ..|   |..:::|.|:..|.|.:|::.|.::|..:|..|:|.|:..|.:::: |...|:|.|:.|
plant   393 NEK---ALEYMRKATKLDPRDAQAFVGLGELLISSDTGAALDAFKMARTLMK-KGGQEVPIEVLN 453

  Fly   456 NVASLHYR-------LGNLKMA------------KLTLE----SALKHATSEMDKDVKYYESI-- 495
            ::.:||:.       |.|.|.|            |..||    |.|.:      ||...:..:
plant   454 DIGALHFEREEFESALENFKEALGDGIWISFLDEKENLEQTGVSVLGY------KDTGIFHRLIE 512

  Fly   496 ----------QVTMKYNLARLNEAMSSYDVADKLYKEILKEHPNYIDCYLRLGCMARDKGLIFVA 550
                      :||..:|||||.|.:...:.|..:|:.||.::|.|||.||||...|:.:..:.:|
plant   513 SGHSVDVPWNKVTTLFNLARLLEQIHKTEAATFMYRLILFKYPGYIDAYLRLAASAKAQNNLPLA 577

  Fly   551 SDFFKDALNINNDNPDARSLLGNLHLAKMQFALGQKNFETILKNPST-STDAYSLIALGNFS-LQ 613
            .:...:||.:::.||:|.||||.|.|....:...::.|..  .|.:| ..|:|::::|||:: ..
plant   578 IELVNEALKVDDKNPNALSLLGELELKNDDWVKAKETFRA--ANDATDGKDSYAILSLGNWNYFA 640

  Fly   614 TLHQPSRDKEKERKHQEKALAIFKQVLRNDPRNIWATNGIGAVLAHKGCVIEARDIFAQVREATA 678
            .:....|:.:.|..|.|||..::.:||.....|::|.||.|.|||.||....|:|:|.||:||.:
plant   641 AMRNEKRNPKLEATHLEKAKELYTKVLTQHNSNMYAANGSGIVLAEKGQFDIAKDVFTQVQEAAS 705

  Fly   679 -----DFCDVWLNIAHVYVEQKQYISAIQMYENCMKKFYKHNNVEVMQYLARAYLRANKLVDAKA 738
                 ...|||:|:||||..|..:...::||:||::||:.:.:.:::.||||.:..|.:..:.|.
plant   706 GSVFLQMPDVWVNLAHVYFAQGNFALTVKMYQNCLRKFFYNTDSQILLYLARTHYEAEQWQECKK 770

  Fly   739 VLLKARRVAPQDTVLLFNIAVVLSRLAMAILKDEKSTLEIVLQAVHELELAQKYFQYLS------ 797
            .||:|..:.|.:....|::..|:.:.:.:.|:.:|.|.:.|...|.|.|.|.:.|..||
plant   771 TLLRAIHLTPSNYTFRFDLGAVMQKSSSSTLQKKKRTADEVRSTVAEAENAVRVFTQLSAASDLH 835

  Fly   798 VHG-DKNRFNIEVAGIEASTCQDLLSQAQYHVGRARRIDEEERSLRRKQEEEREAFKIKVAEQRK 861
            ||| |..:....|     ..|..||..|:.|...|   ::||...|::.|..|:|   .:||:.:
plant   836 VHGFDSKKIQTHV-----QYCSHLLEAAKVHREAA---EQEELQNRQRLEVARQA---ALAEEAR 889

  Fly   862 RREEE------AKTSRDQLLAKRQEYVEKTKNMLIIADAPPEKERKKG---GGRGRKDDYISGTE 917
            |:.||      .|..:::.|.:.::..||.:.:         ||:.|.   |...|||     ..
plant   890 RKAEEQRKYQLEKRKQEEELRRLKQEEEKFQRI---------KEQWKSSTPGSNKRKD-----RV 940

  Fly   918 SDNDGARREGERPSKKKGKGERKKGGGRKRKTEK------YESDSE-----------EEPGASGK 965
            .|:||..:..||         |:|.||::||.:|      ||.|.|           |:..|:..
plant   941 EDDDGESKPSER---------RRKKGGKRRKKDKSSRARHYEDDEEEAATMDDHNEVEDEDANTN 996

  Fly   966 SGKK----KGKKPKPVKESKEKLSAKQRLKVLSKETISTSESESDGKRSKSRSRSRSRNRSGSRS 1026
            ..::    ..:..:||.:....|.|...|:   ...:...|..:.|.|   |.|:.|   |....
plant   997 YNREDEMTTQEAEEPVDDDAHDLLAAAGLE---DPDVDDDEVPTSGVR---RRRALS---SSDEE 1052

  Fly  1027 GSASRSGSDREASRKRSRSRSGSGSGSDSDEATKRKRA 1064
            |..........:.:|.....:|.....:.:|..:.:.|
plant  1053 GELMEESHPNSSPQKEKEESNGEAGDPNMEEEEEEEEA 1090

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctr9	NP_788448.1	TPR repeat	130..157	CDD:276809	7/26 (27%)
		TPR_11	166..228	CDD:290150	28/61 (46%)
		TPR repeat	166..191	CDD:276809	10/24 (42%)
		TPR repeat	196..227	CDD:276809	15/30 (50%)
		TPR repeat	269..300	CDD:276809	12/30 (40%)
		TPR_11	305..372	CDD:290150	26/69 (38%)
		TPR repeat	306..334	CDD:276809	11/30 (37%)
		TPR repeat	340..370	CDD:276809	13/29 (45%)
		TPR_1	344..374	CDD:278916	11/29 (38%)
		TPR repeat	375..406	CDD:276809	10/30 (33%)
		NRDE-2	400..>532	CDD:285605	44/166 (27%)
		TPR repeat	412..437	CDD:276809	7/24 (29%)
		TPR repeat	501..525	CDD:276809	9/23 (39%)
		TPR repeat	530..560	CDD:276809	11/29 (38%)
		TPR repeat	565..593	CDD:276809	9/27 (33%)
		TPR repeat	646..676	CDD:276809	15/29 (52%)
		TPR repeat	681..709	CDD:276809	13/27 (48%)
		TPR_11	682..748	CDD:290150	24/65 (37%)
		TPR repeat	716..746	CDD:276809	9/29 (31%)
ELF8	NP_178674.7	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	109	1.000	Domainoid score	I2129
eggNOG	1	0.900	-	-		E2759_KOG2002
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40668
Inparanoid	1	1.050	497	1.000	Inparanoid score	I322
OMA	1	1.010	-	-		QHG54530
OrthoDB	1	1.010	-	-		D396755at2759
OrthoFinder	1	1.000	-	-		FOG0003745
OrthoInspector	1	1.000	-	-		oto4224
orthoMCL	1	0.900	-	-		OOG6_102191
Panther	1	1.100	-	-	LDO	PTHR14027
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4182
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.880