DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ctr9 and CG9899

DIOPT Version :9

Sequence 1:	NP_788448.1	Gene:	Ctr9 / 38149	FlyBaseID:	FBgn0035205	Length:	1150	Species:	Drosophila melanogaster
Sequence 2:	NP_611764.1	Gene:	CG9899 / 37676	FlyBaseID:	FBgn0034829	Length:	922	Species:	Drosophila melanogaster

Alignment Length:	992	Identity:	296/992 - (29%)
Similarity:	488/992 - (49%)	Gaps:	99/992 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LHVWVNVALAYYKQKKTEDFVTLLEESRSDDATKEYRDSDKDLMRALDMLAAHYVQEAYREKSKD 104
            |..::..|:.:|...|..||..::|:..:...| .|...|::|.:|..:||.:....|::   ..
  Fly     5 LSTYIEEAMEFYAIGKGADFKAIIEKGIASCMT-TYSTYDRELYKAYALLATYLSNHAFK---II 65

  Fly   105 KKRELFM-KATNLYTSADKIIMYDQSHL-LGRAYFCLLEGDKMDQADAQFNFVLNQSPSNIPSLL 167
            |.|..|. .|.|.:...|.:......|| :.:.:..:|...:...|||....||...|.||.:|:
  Fly    66 KSRPAFQAMAINCFDQLDSLRQQHDPHLQVTKGFLWMLSSSRAQDADALLISVLRNHPKNILALI 130

  Fly   168 GKACIAFNRKDYRGAMAFYKKALRTNPNCPANVRIGMAHCFLKMGNPEKAKLAFERALQLDQQCV 232
            |:||:|:||:||.||:.::|..|...|...|:|.:|:.|||.|||..|||:|:|:.||:.:.||:
  Fly   131 GRACLAYNRQDYIGALGYFKSVLLIQPQGMADVWVGIGHCFWKMGELEKAQLSFQIALEHNGQCL 195

  Fly   233 GALIGLAVLKLNQLEPESNKLGVQMLSKAYTIDNANPMVLNHLANHFFFKKDYQKVHHLALHAFH 297
            .|.:.||::|....:.:|.:.|..:|:.||..:|.||.:|:.||..::...:::.|...|.:|..
  Fly   196 NAALALALVKFEHNDEQSYQDGKMLLTAAYKENNKNPDLLSILAGMYYADGNHKLVWSFAGNAIK 260

  Fly   298 NTENEAMRAESCYQLARSFHAQSDYDQAFQYYYQSTQIAPANFVLPHYGLGQMYIYRGDTENAAQ 362
            .|.|:.:.:.:.:|:|:|:||...::.|.:||..|.:.||..::||..|:.|||::.|:...:..
  Fly   261 FTANKHIESRNYFQIAKSYHATGQFESAKKYYLLSAKSAPDGYILPLVGVAQMYLHEGELNRSKA 325

  Fly   363 CFEKVLKIQPGNYETMKILGSLYAHSNSQTKRDMAKTHLKKVTE--QFPEDIEAWIELAQILEQN 425
            ..|..|..:|.....|.:|..:|.......|.|.|...|.||.|  .:.::..:|:.||...||.
  Fly   326 FLESFLTSEPDEPVVMDLLAKIYLEYKCPEKIDKAIEMLVKVVESASYHQNTNSWLNLAFAYEQK 390

  Fly   426 DLQA-SLSAYGTASSILRDKAKYEIPAEIQNNVASLHYRLGNLKMAKL------TLESALKHATS 483
            .|.| .::||..|..|...:. ::||.|..||:||      :..|||:      ||:.||... .
  Fly   391 RLWAHGVNAYQKAIDIYLSQG-HQIPIEWLNNLAS------SQLMAKMPEKALNTLDDALSKC-R 447

  Fly   484 EMDKDVKYYESIQVTMKYNLARLNEAMSSYDVADKLYKEILKEHPNYIDCYLRLGCMARDKGLIF 548
            .|:.|.|  .:..::::||...:.|.:..:.:|.:.||.|.||:.:|.|||||||.||..|....
  Fly   448 VMNSDNK--TTNLLSLQYNRGLVLEELHMFTLAAENYKSITKEYSSYHDCYLRLGVMAIQKNNHT 510

  Fly   549 VASDFFKDALNINNDNPDARSLLGNLH--LAKMQFALGQKNFETILKNPSTSTDAYSLIALGNFS 611
            .|.:..||.|..:|.|..||:.:|:..  |:..:||  ..|:..||...|..|:.|..:|:|||.
  Fly   511 QAIEHLKDILVEDNLNMTARTYMGDCFKGLSLDKFA--TFNYNMILARQSKFTNTYVSMAMGNFC 573

  Fly   612 LQTLHQ--PSRDKEKERKHQEKALAIFKQVLRNDPRNIWATNGIGAVLAHKGCVIEARDIFAQVR 674
            |:.|..  ...:....||.|||||..|.::|..:|:|:||.|||||||:....:.....||.|:.
  Fly   574 LEKLQNWIAEGNFRAARKQQEKALQCFGKILDCNPKNLWAANGIGAVLSSCNNLSAGGAIFKQII 638

  Fly   675 EATADFCDVWLNIAHVYVEQKQYISAIQMYENCMKKFYKHNNVEVMQYLARAYLRANKLVDAKAV 739
            |.........:|.||:.:...||..|||.||.|:|.....|.|:||..||:|.........||..
  Fly   639 ECGNKCIPAIINSAHIALVSGQYRLAIQTYERCLKDHLPKNRVDVMHCLAKALYDNGDARKAKMW 703

  Fly   740 LLKARRVAPQDTVLLFNIAVVLSRLAMAILKDEKSTLEIVLQAVHE-------LELAQKYFQYLS 797
            |||.|.:.|.|..::||       |.:||.|:.:..|.:....:.|       |::|.|.|.:::
  Fly   704 LLKVRHLVPHDPFVIFN-------LGLAIKKETEQALALPRPQLDELMGLDGLLKVAFKLFCHIN 761

  Fly   798 VHGDKNRFNIEVAGIEASTCQDLLSQAQYHVGRARRIDEEERSLRRKQEEEREAFKIKVAEQRK- 861
            ::..|  .::.|:...|..||:|:::.   :.:.|:..|.......:.:.:::.::..:..||:
  Fly   762 LNHPK--ISVRVSAKYAEDCQNLMTEL---IAKKRQASESHAMEEDRVQLQKQRYRDHIEHQRQQ 821

  Fly   862 --RREEEAKTSRDQLLAKRQEYVEKTKNMLIIADAPPEKERKKGGGRGRKDDYISGTESDNDGAR 924
              :||||.:..|:.|..:|:|.:|:|:.::....||...::..|.||.:|
  Fly   822 ELQREEEERVRRENLKIQRKEVLERTRKIISAPLAPDVPKKSAGNGRAKK--------------- 871

  Fly   925 REGERPSKKKGKGERKKGGGRKRKTEKYESDSEEEPGASGKSGKKKGKKPKPVKESKEKLSAKQR 989
                  :::.|.|:.||.|..|:||.|..:..|:|             ..:|:|:.|
  Fly   872 ------NQENGDGKAKKSGPPKKKTRKRAAGKEQE-------------DIEPLKKPK-------- 909

  Fly   990 LKVLSKETISTSESESD 1006
                |||.|.|.:..|:
  Fly   910 ----SKEFIDTDDDNSE 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctr9	NP_788448.1	TPR repeat	130..157	CDD:276809	7/27 (26%)
		TPR_11	166..228	CDD:290150	30/61 (49%)
		TPR repeat	166..191	CDD:276809	12/24 (50%)
		TPR repeat	196..227	CDD:276809	16/30 (53%)
		TPR repeat	269..300	CDD:276809	7/30 (23%)
		TPR_11	305..372	CDD:290150	20/66 (30%)
		TPR repeat	306..334	CDD:276809	9/27 (33%)
		TPR repeat	340..370	CDD:276809	9/29 (31%)
		TPR_1	344..374	CDD:278916	8/29 (28%)
		TPR repeat	375..406	CDD:276809	9/30 (30%)
		NRDE-2	400..>532	CDD:285605	42/140 (30%)
		TPR repeat	412..437	CDD:276809	9/25 (36%)
		TPR repeat	501..525	CDD:276809	7/23 (30%)
		TPR repeat	530..560	CDD:276809	15/29 (52%)
		TPR repeat	565..593	CDD:276809	8/29 (28%)
		TPR repeat	646..676	CDD:276809	13/29 (45%)
		TPR repeat	681..709	CDD:276809	11/27 (41%)
		TPR_11	682..748	CDD:290150	25/65 (38%)
		TPR repeat	716..746	CDD:276809	12/29 (41%)
CG9899	NP_611764.1	TPR_11	125..191	CDD:290150	32/65 (49%)
		TPR repeat	125..155	CDD:276809	15/29 (52%)
		TPR repeat	161..189	CDD:276809	15/27 (56%)
		TPR	174..443	CDD:223533	85/275 (31%)
		TPR repeat	272..297	CDD:276809	9/24 (38%)
		PEP_TPR_lipo	275..>735	CDD:274350	160/478 (33%)
		TPR repeat	303..333	CDD:276809	9/29 (31%)
		TPR repeat	338..369	CDD:276809	9/30 (30%)
		TPR repeat	376..406	CDD:276809	10/29 (34%)
		TPR repeat	416..444	CDD:276809	11/33 (33%)
		TPR repeat	458..488	CDD:276809	7/29 (24%)
		TPR repeat	493..520	CDD:276809	13/26 (50%)
		TPR repeat	580..605	CDD:276809	8/24 (33%)
		TPR repeat	610..640	CDD:276809	13/29 (45%)
		TPR repeat	645..673	CDD:276809	11/27 (41%)
		TPR repeat	680..710	CDD:276809	12/29 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468519
Domainoid	1	1.000	87	1.000	Domainoid score	I1841
eggNOG	1	0.900	-	-		E2759_KOG2002
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	265	1.000	Inparanoid score	I732
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54530
OrthoDB	1	1.010	-	-		D396755at2759
OrthoFinder	1	1.000	-	-		FOG0003745
OrthoInspector	1	1.000	-	-		otm46817
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR14027
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	10	9.910