DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ctr9 and tpr1

DIOPT Version :9

Sequence 1:	NP_788448.1	Gene:	Ctr9 / 38149	FlyBaseID:	FBgn0035205	Length:	1150	Species:	Drosophila melanogaster
Sequence 2:	NP_594620.1	Gene:	tpr1 / 2542077	PomBaseID:	SPAC27D7.14c	Length:	1039	Species:	Schizosaccharomyces pombe

Alignment Length:	1107	Identity:	293/1107 - (26%)
Similarity:	505/1107 - (45%)	Gaps:	198/1107 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SNCIEIP-LQDTDEVIEVDPDQLP-DCPEVLSILKQERAPLHVWVNVALAYYKQKKTEDFVTLLE 64
            |..||:| |...|:.:|:|...|| |..|:..||..|:||...|...|..||.:...|..:.:|:
pombe    11 SRIIEVPLLGQEDQSVEIDCSSLPSDATELCEILVNEQAPREFWTKFAHEYYIRGLREQAILILK 75

  Fly    65 ESRSDDATKEYRDSDK-DLMRALDMLAAHYV---QEAYREKSKDKKRE------LFMKATNLYTS 119
                 ...:..:||:. .::.|  .:||.|:   :||..:|..|.:.|      .:::|.|...|
pombe    76 -----SGLETLKDSESLCILNA--NIAAIYLSMAREAMLKKDTDLRDEQLRNVRTYLEAANNIDS 133

  Fly   120 ADKIIMYDQSHLLGRAYFCLL---EGDKMDQADAQFNFVLNQSPSNIPSLLGKACIAFNRKDYRG 181
            ..:|     :.||...|..||   :.:.::.|...|:|||.:|..||...||||.|.:.:.:||.
pombe   134 KSEI-----NVLLHGIYRILLNPTDKESLENAARCFDFVLQKSGGNILGFLGKARILYAKGNYRS 193

  Fly   182 AMAFYKKALRTNPNCPANVRIGMAHCFLKMGNPEKAKLAFERALQLDQQ--CVGALIGLAVLKL- 243
            |:..|::||.:||....:.|||:..||..:.....|..|:.|..|||.:  .|...|||....|
pombe   194 ALKLYQRALVSNPQFKPDPRIGIGLCFWNLDMKTDALSAWTRVQQLDPKNTVVDTYIGLYYYDLA 258

  Fly   244 -----NQLEPESNKLGVQMLSKAYTIDNANPMVLNHLANHFFFKKDYQKVHHLALHAFHNTENEA 303
                 |....::....:|.:.:|:...|.:|:..:.|..:.:.||:|:....||.:...|:.:.:
pombe   259 FQNVNNDSFVQNYGKALQHIQRAFKTRNNDPVASSILERYVYSKKNYEGCIKLAENVIQNSFSSS 323

  Fly   304 MRAESCYQLARSFHAQSDYDQAFQYYYQSTQIAPANFVLPHYGLGQMYIYRGDTENAAQCFEKVL 368
            :.|:..|.:.|::|...:.::|.. .||..:.|....:|...|:||:.|.:.|..:|...||::.
pombe   324 LIADGYYWMGRAYHQMGNNEKAMA-SYQKAKAADDRHLLSSVGIGQIQILQNDLTSAKLTFERIA 387

  Fly   369 KIQPGNYETMKILGSLYAHSNSQTKRDMAKTH--LKKV-----TEQFPE--DIEAWIELAQILEQ 424
            :.....:|.:.:||.|:|   |.:|.|:.|..  |.:.     :.:.|.  |.:.:|..|::.|:
pombe   388 EQNQSCFEALVVLGCLHA---SDSKPDLTKARMLLDRAFNLVGSSKLPRVVDSDLYITQARLWEK 449

  Fly   425 NDLQASLSAYGTASSILRDKAKYEIPAEIQNNVASLHYRLGNLKMAK---LTLESALKHATSEMD 486
            .|.:.||.....|...| :.|...:..|:.||:|.|.|.||.:..|.   :..:|.|..|..|
pombe   450 EDTKKSLGFLTRALDFL-ESAHMSVGPELLNNIAVLQYHLGLIPEAHGNIIKAKSVLPDANPE-- 511

  Fly   487 KDVKYYESIQVTMKYNLARLNEAMSSYDVADKLYKEILKEHPNYIDCYLRLGCMARDKGLIFVAS 551
                    :.:.:.|||||..|.:.:..||.:.|..||::||::||..:|       |.|:.:::
pombe   512 --------LSLLLDYNLARCEEELGNTSVASEAYVSILEKHPSFIDARIR-------KCLLQLSN 561

  Fly   552 ---DFFKD---ALNINNDNPDARSLLGNLHLAKMQFALGQKNFETILKNPST----------STD 600
               :.||:   .:|.::.|.:.|:..| .:|:|.:        ...:::|..          ..|
pombe   562 PNEETFKEIRHIMNADSQNLEVRAFFG-WYLSKQK--------RRPVEDPEVRHCSQTLRHWHDD 617

  Fly   601 AYSLIALGNFSLQTLHQ----PSRDKEKERKHQEKALAIFKQVLRNDPRNIWATNGIGAVLAHKG 661
            .|||:.|||..::...:    ..|:|.|.:|...||:..:.|.::.||:|..|..||..:||...
pombe   618 IYSLVQLGNAYMRQAREFRVHNDREKLKRQKLYIKAIQSYDQAIKFDPKNAHAAQGIAIILAQNR 682

  Fly   662 CVIEARDIFAQVREATADFCDVWLNIAHVYVEQKQYISAIQMYENCMKKFYKHNNVEVMQYLARA 726
            ...:|..|.::||||..| ....:||.:...|.||:..||:::|.......:.:...|:..|.|.
pombe   683 QFSKALLILSKVREAIKD-ATTLINIGNCLAELKQFSRAIEVFETVYSSTGESDTYGVLSCLGRV 746

  Fly   727 YL---RANKLVDAKAVLLKARRVA-------PQDTVLLFNIAVVLSRLAMAI-LKDEKS-TLEIV 779
            :|   |.:|.||   .|.::.|.|       |::..||||:|.|..:|...| .|.|.| |:|.:
pombe   747 WLQRGRESKNVD---YLKESVRYATLALEKNPENPSLLFNVAFVQFQLCELIRQKPENSRTVEDL 808

  Fly   780 LQAVHELELA-QKYFQYLSV-HGDKNRFNIEV-AGIEASTCQDLLSQA----------------- 824
            ..|:.:|:.: :.:.:.:|| |...:..:||. |.:..:|.:..|.:|
pombe   809 NFAMQQLDASIETFTKLVSVEHPPYSPTSIEQRAKMAKNTTKRQLERAIQAQIEYEKSVAAKLED 873

  Fly   825 ---QYHVGRARRIDEEERSLRRKQEEEREAFKIKVAEQRKRREEEAKTSRDQLLAKRQEYVEKTK 886
               |....:|||:.|||..|:.|||.||:     :.|:|::.:||.
pombe   874 ARIQREKEKARRLAEEEALLKEKQERERQ-----LQEERQKMQEEV------------------- 914

  Fly   887 NMLIIADAPPEKERKKGGGRGRKDDYISGTESDNDGARREGERPSKKKGKGERKKGGGRKRKTEK 951
                       .|.:|...:..:||.   :.||::      |:.|.||.|.:|||   ||.|:::
pombe   915 -----------LEWRKSQQKASEDDM---SLSDDE------EKQSGKKKKKDRKK---RKSKSKQ 956

  Fly   952 YESDSEEEPGASGKSGKKKGKKPKPVKESKEKLSAKQRL--KVLSKETISTSESESDGKRSKSRS 1014
            ..|||    |.|...       ..|:.:::.| :.|:|:  :|:|:|.....:|:::|.:.:..|
pombe   957 ESSDS----GVSEDD-------EIPLSDARNK-TKKRRVNRRVISEEYTFDQDSDAEGNQEEEVS 1009

  Fly  1015 RS 1016
            |:
pombe  1010 RT 1011

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctr9	NP_788448.1	TPR repeat	130..157	CDD:276809	9/29 (31%)
		TPR_11	166..228	CDD:290150	22/61 (36%)
		TPR repeat	166..191	CDD:276809	10/24 (42%)
		TPR repeat	196..227	CDD:276809	8/30 (27%)
		TPR repeat	269..300	CDD:276809	8/30 (27%)
		TPR_11	305..372	CDD:290150	17/66 (26%)
		TPR repeat	306..334	CDD:276809	7/27 (26%)
		TPR repeat	340..370	CDD:276809	9/29 (31%)
		TPR_1	344..374	CDD:278916	8/29 (28%)
		TPR repeat	375..406	CDD:276809	10/37 (27%)
		NRDE-2	400..>532	CDD:285605	38/143 (27%)
		TPR repeat	412..437	CDD:276809	6/24 (25%)
		TPR repeat	501..525	CDD:276809	10/23 (43%)
		TPR repeat	530..560	CDD:276809	7/35 (20%)
		TPR repeat	565..593	CDD:276809	4/27 (15%)
		TPR repeat	646..676	CDD:276809	10/29 (34%)
		TPR repeat	681..709	CDD:276809	8/27 (30%)
		TPR_11	682..748	CDD:290150	19/75 (25%)
		TPR repeat	716..746	CDD:276809	9/32 (28%)
tpr1	NP_594620.1	TPR_11	174..241	CDD:290150	25/66 (38%)
		TPR repeat	178..203	CDD:276809	10/24 (42%)
		TPR repeat	208..239	CDD:276809	8/30 (27%)
		TPR repeat	244..283	CDD:276809	8/38 (21%)
		tol_pal_ybgF	299..389	CDD:188247	23/90 (26%)
		TPR_8	326..356	CDD:289924	7/30 (23%)
		TPR repeat	326..354	CDD:276809	7/28 (25%)
		TPR repeat	359..389	CDD:276809	9/29 (31%)
		TPR repeat	394..422	CDD:276809	10/30 (33%)
		TPR_12	664..729	CDD:290160	23/65 (35%)
		TPR repeat	667..696	CDD:276809	9/28 (32%)
		TPR repeat	701..729	CDD:276809	8/27 (30%)
		TPR repeat	736..773	CDD:276809	11/39 (28%)
		TrbI	793..>916	CDD:305006	34/157 (22%)
		COX16	<875..916	CDD:290843	17/75 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	50	1.000	Domainoid score	I3399
eggNOG	1	0.900	-	-		E2759_KOG2002
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	265	1.000	Inparanoid score	I732
OMA	1	1.010	-	-		QHG54530
OrthoFinder	1	1.000	-	-		FOG0003745
OrthoInspector	1	1.000	-	-		otm47271
orthoMCL	1	0.900	-	-		OOG6_102191
Panther	1	1.100	-	-	LDO	PTHR14027
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1541
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.900