DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ctr9 and Ctr9

DIOPT Version :9

Sequence 1:	NP_788448.1	Gene:	Ctr9 / 38149	FlyBaseID:	FBgn0035205	Length:	1150	Species:	Drosophila melanogaster
Sequence 2:	NP_033457.2	Gene:	Ctr9 / 22083	MGIID:	109345	Length:	1173	Species:	Mus musculus

Alignment Length:	1200	Identity:	692/1200 - (57%)
Similarity:	864/1200 - (72%)	Gaps:	89/1200 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IEIPLQDTDEVIEVDPDQLPDCPEVLSILKQERAPLHVWVNVALAYYKQKKTEDFVTLLEESRSD 69
            |||||:|||||||:|.||||:..||:||||||...||:|:.:||.||||.|||:||.|||.:|.
Mouse     6 IEIPLRDTDEVIELDFDQLPEGDEVISILKQEHTQLHIWIALALEYYKQGKTEEFVKLLEAARI- 69

  Fly    70 DATKEYRDSDKDLMRALDMLAAHYVQEAYREKSKDKKRELFMKATNLYTSADKIIMYDQSHLLGR 134
            |...:|||.:||.|..||.|||:|||:|.:||:||.|::|..:||.|||.|||||||||:|||||
Mouse    70 DGNLDYRDHEKDQMTCLDTLAAYYVQQARKEKNKDNKKDLITQATLLYTMADKIIMYDQNHLLGR 134

  Fly   135 AYFCLLEGDKMDQADAQFNFVLNQSPSNIPSLLGKACIAFNRKDYRGAMAFYKKALRTNPNCPAN 199
            |.||||||||||||||||:|||||||:|||:|||||||:||:||||||:|:|||||||||.|||.
Mouse   135 ACFCLLEGDKMDQADAQFHFVLNQSPNNIPALLGKACISFNKKDYRGALAYYKKALRTNPGCPAE 199

  Fly   200 VRIGMAHCFLKMGNPEKAKLAFERALQLDQQCVGALIGLAVLKLNQLEPESNKLGVQMLSKAYTI 264
            ||:||.|||:|:...|||:|||.|||:|:.:|||||:|||||:||..|.:|.|.|||:||:||||
Mouse   200 VRLGMGHCFVKLNKLEKARLAFSRALELNSKCVGALVGLAVLELNNKEADSIKNGVQLLSRAYTI 264

  Fly   265 DNANPMVLNHLANHFFFKKDYQKVHHLALHAFHNTENEAMRAESCYQLARSFHAQSDYDQAFQYY 329
            |.:||||||||||||||||||.||.|||||||||||.|||:||||||||||||.|.|||||||||
Mouse   265 DPSNPMVLNHLANHFFFKKDYSKVQHLALHAFHNTEVEAMQAESCYQLARSFHVQEDYDQAFQYY 329

  Fly   330 YQSTQIAPANFVLPHYGLGQMYIYRGDTENAAQCFEKVLKIQPGNYETMKILGSLYAHSNSQTKR 394
            ||:||.|.::||||.:|||||||||||.|||:||||||||..|.|||||||||||||.|..|.||
Mouse   330 YQATQFASSSFVLPFFGLGQMYIYRGDKENASQCFEKVLKAYPNNYETMKILGSLYAASEDQEKR 394

  Fly   395 DMAKTHLKKVTEQFPEDIEAWIELAQILEQNDLQASLSAYGTASSILRDKAKYEIPAEIQNNVAS 459
            |:||.||||||||:|:|:||||||||||||.|:|.:|||||||:.||::|.:.::|.||.|||.:
Mouse   395 DIAKGHLKKVTEQYPDDVEAWIELAQILEQTDIQGALSAYGTATRILQEKVQADVPPEILNNVGA 459

  Fly   460 LHYRLGNLKMAKLTLESALKHATSEMDKDVKYYESIQVTMKYNLARLNEAMSSYDVADKLYKEIL 524
            ||:|||||..||....::|..|.:|.:.|..||.:|.||..||||||.|||..:..|:||||.||
Mouse   460 LHFRLGNLGEAKKYFLASLDRAKAEAEHDEHYYNAISVTTSYNLARLYEAMCEFHEAEKLYKNIL 524

  Fly   525 KEHPNYIDCYLRLGCMARDKGLIFVASDFFKDALNINNDNPDARSLLGNLHLAKMQFALGQKNFE 589
            :|||||:|||||||.||||||..:.|||:||:||.||.|:|||.||:|||||||.::..|||.||
Mouse   525 REHPNYVDCYLRLGAMARDKGNFYEASDWFKEALQINQDHPDAWSLIGNLHLAKQEWGPGQKKFE 589

  Fly   590 TILKNPSTSTDAYSLIALGNFSLQTLHQPSRDKEKERKHQEKALAIFKQVLRNDPRNIWATNGIG 654
            .|||.|:|.:|.||::||||..|||||||:||:|||::||::||||:|||||||.:|::|.||||
Mouse   590 RILKQPATQSDTYSMLALGNVWLQTLHQPTRDREKEKRHQDRALAIYKQVLRNDAKNLYAANGIG 654

  Fly   655 AVLAHKGCVIEARDIFAQVREATADFCDVWLNIAHVYVEQKQYISAIQMYENCMKKFYKHNNVEV 719
            |||||||...||||:||||||||||..|||||:||:||||||||||:||||||::|||||.|.||
Mouse   655 AVLAHKGYFREARDVFAQVREATADISDVWLNLAHIYVEQKQYISAVQMYENCLRKFYKHQNTEV 719

  Fly   720 MQYLARAYLRANKLVDAKAVLLKARRVAPQDTVLLFNIAVVLSRLAMAILKDEKSTLEIVLQAVH 784
            :.|||||..:..||.:.|..|||||.|||.||||:||:|:||.|||.::||||||.|:.||.||.
Mouse   720 VLYLARALFKCGKLQECKQTLLKARHVAPSDTVLMFNVALVLQRLATSVLKDEKSNLKEVLNAVK 784

  Fly   785 ELELAQKYFQYLSVHGDKNRFNIEVAGIEASTCQDLLSQAQYHVGRARRIDEEERSLRRKQEEER 849
            |||||.:||.|||..|||.||::.:|..||..|.||||||||||.|||:.|||||.||.|||:|:
Mouse   785 ELELAHRYFSYLSKVGDKMRFDLALAASEARQCSDLLSQAQYHVARARKQDEEERELRAKQEQEK 849

  Fly   850 EAFKIKVAEQRKRREEEAKTSRDQLLAKRQEYVEKTKNMLII-ADAPPEKERKKGGGRGRK---- 909
            |..:.|:.::::.:....|..:.:||.:|.:|||||||:|:. .:....||:|:|||.||:
Mouse   850 ELLRQKLLKEQEEKRLREKEEQKKLLEQRAQYVEKTKNILMFTGETEATKEKKRGGGGGRRSKKG 914

  Fly   910 ---DDYISGTESDND-------------GARREGERPSKKKGKGERKKGGGRKRKTEKYESDSEE 958
               |:::: .::|:|             |:.:|||   :::| |||||  .|:|:..|.|..|||
Mouse   915 GEFDEFVN-DDTDDDLPVSKKKKRRKGSGSEQEGE---EEEG-GERKK--KRRRRPPKGEEGSEE 972

  Fly   959 EPGASGKSGKK-------KGKKPKPVKESKEKLSAKQRLKVLSKETISTSESESD---------- 1006
            |...:|...||       |.|.|||     |:|....:.|:.||..||:|:..||
Mouse   973 EETENGPKPKKRRPPRAEKKKAPKP-----ERLPPSMKGKIKSKAIISSSDDSSDEDKLKIADEG 1032

  Fly  1007 ---------------GKRSKSRSRS-RSRNRSGSRSGSASRSGSDREASRKRSRSRSGSGSGSDS 1055
                           .:|:.|.|.| .::|:|||.:||..|||            |..|...|||
Mouse  1033 HPRNSNSDSDDDERPNRRASSESDSDDNQNKSGSEAGSPRRSG------------RQESDEDSDS 1085

  Fly  1056 DEATKRKRARNRIESGGESDRSGSRARSKSSSRSRSRSKSGSRSRSRSKSGSRSRSRSKSGSRSR 1120
            |:.::::|.....:|..||.:||   ||.|.:   |.:::.||..|.|   :.|...|:.||.:.
Mouse  1086 DQPSRKRRRSGSEQSDNESVQSG---RSPSGA---SENENDSRPASPS---AESDHESEQGSDNE 1141

  Fly  1121 -SRSPSGSRSRSRSGSRSKSESRSRSGSPE 1149
             |...||:.|.....:...|:..|..||.:
Mouse  1142 GSGQGSGNESEPEGSNNEASDRGSEHGSDD 1171

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctr9	NP_788448.1	TPR repeat	130..157	CDD:276809	24/26 (92%)
		TPR_11	166..228	CDD:290150	45/61 (74%)
		TPR repeat	166..191	CDD:276809	20/24 (83%)
		TPR repeat	196..227	CDD:276809	20/30 (67%)
		TPR repeat	269..300	CDD:276809	28/30 (93%)
		TPR_11	305..372	CDD:290150	53/66 (80%)
		TPR repeat	306..334	CDD:276809	24/27 (89%)
		TPR repeat	340..370	CDD:276809	25/29 (86%)
		TPR_1	344..374	CDD:278916	23/29 (79%)
		TPR repeat	375..406	CDD:276809	24/30 (80%)
		NRDE-2	400..>532	CDD:285605	79/131 (60%)
		TPR repeat	412..437	CDD:276809	19/24 (79%)
		TPR repeat	501..525	CDD:276809	15/23 (65%)
		TPR repeat	530..560	CDD:276809	21/29 (72%)
		TPR repeat	565..593	CDD:276809	18/27 (67%)
		TPR repeat	646..676	CDD:276809	22/29 (76%)
		TPR repeat	681..709	CDD:276809	23/27 (85%)
		TPR_11	682..748	CDD:290150	45/65 (69%)
		TPR repeat	716..746	CDD:276809	16/29 (55%)
Ctr9	NP_033457.2	TPR 1	41..75		19/33 (58%)
		TPR 2	129..162		29/32 (91%)
		TPR repeat	131..157	CDD:276809	23/25 (92%)
		TPR 3	163..196		27/32 (84%)
		TPR_11	165..228	CDD:290150	46/62 (74%)
		TPR repeat	165..191	CDD:276809	20/25 (80%)
		TPR repeat	196..227	CDD:276809	19/30 (63%)
		TPR_11	198..266	CDD:290150	43/67 (64%)
		TPR 4	198..231		20/32 (63%)
		TPR 5	235..268		22/32 (69%)
		TPR repeat	269..297	CDD:276809	25/27 (93%)
		TPR 6	306..339		27/32 (84%)
		TPR repeat	306..334	CDD:276809	24/27 (89%)
		tol_pal_ybgF	310..414	CDD:188247	81/103 (79%)
		TPR repeat	340..370	CDD:276809	24/29 (83%)
		TPR 7	341..374		26/32 (81%)
		TPR repeat	375..406	CDD:276809	24/30 (80%)
		TPR 8	412..444		24/31 (77%)
		TPR repeat	412..437	CDD:276809	19/24 (79%)
		TPR repeat	444..487	CDD:276809	19/42 (45%)
		TPR 9	451..484		17/32 (53%)
		TPR_12	453..521	CDD:290160	34/67 (51%)
		TPR 10	497..530		20/32 (63%)
		TPR_12	498..563	CDD:290160	44/64 (69%)
		TPR repeat	501..525	CDD:276809	14/23 (61%)
		TPR repeat	530..560	CDD:276809	21/29 (72%)
		TPR 11	531..564		23/32 (72%)
		TPR repeat	565..593	CDD:276809	17/27 (63%)
		TPR 12	566..598		21/31 (68%)
		TPR 13	613..646		25/32 (78%)
		TPR_11	646..709	CDD:290150	49/62 (79%)
		TPR 14	647..680		25/32 (78%)
		TPR repeat	648..675	CDD:276809	19/26 (73%)
		TPR repeat	680..712	CDD:276809	24/31 (77%)
		TPR 15	681..714		25/32 (78%)
		TPR 16	717..750		18/32 (56%)
		TPR repeat	717..743	CDD:276809	12/25 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	892..1173		92/313 (29%)
		SEEEED	1039..1159	CDD:291463	32/112 (29%)
		PHA02664	<1051..1154	CDD:177447	30/100 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849141
Domainoid	1	1.000	241	1.000	Domainoid score	I2241
eggNOG	1	0.900	-	-		E2759_KOG2002
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40668
Inparanoid	1	1.050	1293	1.000	Inparanoid score	I160
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54530
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003745
OrthoInspector	1	1.000	-	-		oto93733
orthoMCL	1	0.900	-	-		OOG6_102191
Panther	1	1.100	-	-	LDO	PTHR14027
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1541
SonicParanoid	1	1.000	-	-		X4182
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.830